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Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children.
Pediatr Int. 2011 Apr; 53(2):143-6.PI

Abstract

BACKGROUND

The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis-specific cytokine/chemokine alterations in cerebrospinal fluid (CSF).

METHODS

We elucidated the cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from children with mumps meningitis and meningitis due to other viral infections using multiplex cytokine measurement. Seventeen cytokines/chemokines, namely interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β), were measured simultaneously in CSF supernatants from eight children with mumps meningitis, 11 children with other types of viral meningitis and eight children with fever without neurological complications such as convulsion.

RESULTS

We found that IL-8, IL-10, IL-12, IL-13 and IFN-γ showed a statistically significant increase in CSF from mumps meningitis when compared to other types of viral meningitis and fever without neurological complications.

CONCLUSION

Mumps meningitis may induce a distinct immunological response when compared with other types of viral meningitis.

Authors+Show Affiliations

Departments of Pediatrics Emergency and Critical Care Medicine, Nippon Medical School, Chiba Hokusoh Hospital, Chiba, Japan. vff13540@nifty.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21501303

Citation

Asano, Takeshi, et al. "Enhanced Expression of Cytokines/chemokines in Cerebrospinal Fluids in Mumps Meningitis in Children." Pediatrics International : Official Journal of the Japan Pediatric Society, vol. 53, no. 2, 2011, pp. 143-6.
Asano T, Ichiki K, Koizumi S, et al. Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children. Pediatr Int. 2011;53(2):143-6.
Asano, T., Ichiki, K., Koizumi, S., Kaizu, K., Hatori, T., Fujino, O., Mashiko, K., Sakamoto, Y., Miyasho, T., & Fukunaga, Y. (2011). Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children. Pediatrics International : Official Journal of the Japan Pediatric Society, 53(2), 143-6. https://doi.org/10.1111/j.1442-200X.2010.03215.x
Asano T, et al. Enhanced Expression of Cytokines/chemokines in Cerebrospinal Fluids in Mumps Meningitis in Children. Pediatr Int. 2011;53(2):143-6. PubMed PMID: 21501303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children. AU - Asano,Takeshi, AU - Ichiki,Kunihiko, AU - Koizumi,Shinya, AU - Kaizu,Kiyohiko, AU - Hatori,Takayuki, AU - Fujino,Osamu, AU - Mashiko,Kunihiro, AU - Sakamoto,Yuichiro, AU - Miyasho,Taku, AU - Fukunaga,Yoshitaka, PY - 2011/4/20/entrez PY - 2011/4/20/pubmed PY - 2011/9/2/medline SP - 143 EP - 6 JF - Pediatrics international : official journal of the Japan Pediatric Society JO - Pediatr Int VL - 53 IS - 2 N2 - BACKGROUND: The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis-specific cytokine/chemokine alterations in cerebrospinal fluid (CSF). METHODS: We elucidated the cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from children with mumps meningitis and meningitis due to other viral infections using multiplex cytokine measurement. Seventeen cytokines/chemokines, namely interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, granulocyte colony-stimulating factor (G-CSF), granulocyte monocyte colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β), were measured simultaneously in CSF supernatants from eight children with mumps meningitis, 11 children with other types of viral meningitis and eight children with fever without neurological complications such as convulsion. RESULTS: We found that IL-8, IL-10, IL-12, IL-13 and IFN-γ showed a statistically significant increase in CSF from mumps meningitis when compared to other types of viral meningitis and fever without neurological complications. CONCLUSION: Mumps meningitis may induce a distinct immunological response when compared with other types of viral meningitis. SN - 1442-200X UR - https://www.unboundmedicine.com/medline/citation/21501303/Enhanced_expression_of_cytokines/chemokines_in_cerebrospinal_fluids_in_mumps_meningitis_in_children_ L2 - https://doi.org/10.1111/j.1442-200X.2010.03215.x DB - PRIME DP - Unbound Medicine ER -