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Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina.
J Med Virol. 2011 Jun; 83(6):935-40.JM

Abstract

The prevalence of hepatitis C virus genotype 4 (HCV-4) is increasing in different parts of the World but in Latin America the data are still scarce. We aimed to characterize HCV-4 isolates from 383 HIV-coinfected patients in Argentina. Sequence analyses were based on the non-structural 5B region of HCV. Results from 18 patients indicated a genetic heterogeneity that involved three genotype 4 subtypes. Sequences were ascribed to subtype 4d (67%), 4a (22%), and 4m (11%). In spite of different sources of transmission were defined among patients, no statistical association was found with the genotype 4 subtype. The scenario is also compatible with multiple importation of the epidemic and there is no evidence for transmission-specific clusters or network-like transmission of HCV-4. This HCV-4 does not represent a recent introduction in Argentina, it circulates in all transmission groups and its presence is increasing among HIV-infected patients.

Authors+Show Affiliations

Argentinean National Reference Center for AIDS, Microbiology Dept., School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21503903

Citation

Bolcic, F, et al. "Molecular Characterization of Hepatitis C Virus Genotype 4 Sequences in HIV-coinfected Patients From Argentina." Journal of Medical Virology, vol. 83, no. 6, 2011, pp. 935-40.
Bolcic F, Jones LR, Laufer N, et al. Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina. J Med Virol. 2011;83(6):935-40.
Bolcic, F., Jones, L. R., Laufer, N., & Quarleri, J. (2011). Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina. Journal of Medical Virology, 83(6), 935-40. https://doi.org/10.1002/jmv.22068
Bolcic F, et al. Molecular Characterization of Hepatitis C Virus Genotype 4 Sequences in HIV-coinfected Patients From Argentina. J Med Virol. 2011;83(6):935-40. PubMed PMID: 21503903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina. AU - Bolcic,F, AU - Jones,L R, AU - Laufer,N, AU - Quarleri,J, PY - 2011/4/20/entrez PY - 2011/4/20/pubmed PY - 2012/9/6/medline SP - 935 EP - 40 JF - Journal of medical virology JO - J Med Virol VL - 83 IS - 6 N2 - The prevalence of hepatitis C virus genotype 4 (HCV-4) is increasing in different parts of the World but in Latin America the data are still scarce. We aimed to characterize HCV-4 isolates from 383 HIV-coinfected patients in Argentina. Sequence analyses were based on the non-structural 5B region of HCV. Results from 18 patients indicated a genetic heterogeneity that involved three genotype 4 subtypes. Sequences were ascribed to subtype 4d (67%), 4a (22%), and 4m (11%). In spite of different sources of transmission were defined among patients, no statistical association was found with the genotype 4 subtype. The scenario is also compatible with multiple importation of the epidemic and there is no evidence for transmission-specific clusters or network-like transmission of HCV-4. This HCV-4 does not represent a recent introduction in Argentina, it circulates in all transmission groups and its presence is increasing among HIV-infected patients. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/21503903/Molecular_characterization_of_hepatitis_C_virus_genotype_4_sequences_in_HIV_coinfected_patients_from_Argentina_ L2 - https://doi.org/10.1002/jmv.22068 DB - PRIME DP - Unbound Medicine ER -