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Rosmarinic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice.
Int Immunopharmacol. 2011 Sep; 11(9):1271-7.II

Abstract

Atopic dermatitis (AD) is one of the most common skin diseases, and its incidence is increasing in industrialized countries. Furthermore, the epicutaneous application of a hapten, such as 2,4-dinitrofluorobenzene (DNFB), evokes an AD-like lesion in NC/Nga mice under specific pathogen-free (SPF) conditions. Rosmarinic acid (RA) is a secondary metabolite that is frequently found in herbs, and has anti-inflammatory, anti-oxidant, and anti-microbial effects. In this study, we studied whether RA is an effective treatment against DNFB-induced AD-like skin lesions in NC/Nga mice. RA at 1 or 5 μM was found to suppress the productions of interferon (IFN)-γ and interleukin (IL)-4 significantly by activated CD4(+) T cells. Furthermore, an intraperitoneal injection of RA at 10 or 50 mg/kg significantly inhibited skin lesion development and ear thickness and total serum IgE level increases in DNFB-treated NC/Nga mice. In addition, intraperitoneal administered RA at 10 or 50 mg/kg significantly inhibited the infiltrations of CD4(+) T, CD8(+) T, and mast cells into DNFB-induced skin lesions in NC/Nga mice. This study suggests that RA suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ and IL-4 production by activated T cells and total serum IgE levels.

Authors+Show Affiliations

Department of Microbiology (BK21), School of Medicine, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21504802

Citation

Jang, An-Hee, et al. "Rosmarinic Acid Attenuates 2,4-dinitrofluorobenzene-induced Atopic Dermatitis in NC/Nga Mice." International Immunopharmacology, vol. 11, no. 9, 2011, pp. 1271-7.
Jang AH, Kim TH, Kim GD, et al. Rosmarinic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. Int Immunopharmacol. 2011;11(9):1271-7.
Jang, A. H., Kim, T. H., Kim, G. D., Kim, J. E., Kim, H. J., Kim, S. S., Jin, Y. H., Park, Y. S., & Park, C. S. (2011). Rosmarinic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. International Immunopharmacology, 11(9), 1271-7. https://doi.org/10.1016/j.intimp.2011.04.007
Jang AH, et al. Rosmarinic Acid Attenuates 2,4-dinitrofluorobenzene-induced Atopic Dermatitis in NC/Nga Mice. Int Immunopharmacol. 2011;11(9):1271-7. PubMed PMID: 21504802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosmarinic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. AU - Jang,An-Hee, AU - Kim,Tae-Ho, AU - Kim,Gun-Dong, AU - Kim,Jeong Eun, AU - Kim,Ha Jin, AU - Kim,Sung Soo, AU - Jin,Young-Ho, AU - Park,Yong Seek, AU - Park,Cheung-Seog, Y1 - 2011/04/17/ PY - 2010/12/13/received PY - 2011/03/09/revised PY - 2011/04/05/accepted PY - 2011/4/21/entrez PY - 2011/4/21/pubmed PY - 2012/2/18/medline SP - 1271 EP - 7 JF - International immunopharmacology JO - Int Immunopharmacol VL - 11 IS - 9 N2 - Atopic dermatitis (AD) is one of the most common skin diseases, and its incidence is increasing in industrialized countries. Furthermore, the epicutaneous application of a hapten, such as 2,4-dinitrofluorobenzene (DNFB), evokes an AD-like lesion in NC/Nga mice under specific pathogen-free (SPF) conditions. Rosmarinic acid (RA) is a secondary metabolite that is frequently found in herbs, and has anti-inflammatory, anti-oxidant, and anti-microbial effects. In this study, we studied whether RA is an effective treatment against DNFB-induced AD-like skin lesions in NC/Nga mice. RA at 1 or 5 μM was found to suppress the productions of interferon (IFN)-γ and interleukin (IL)-4 significantly by activated CD4(+) T cells. Furthermore, an intraperitoneal injection of RA at 10 or 50 mg/kg significantly inhibited skin lesion development and ear thickness and total serum IgE level increases in DNFB-treated NC/Nga mice. In addition, intraperitoneal administered RA at 10 or 50 mg/kg significantly inhibited the infiltrations of CD4(+) T, CD8(+) T, and mast cells into DNFB-induced skin lesions in NC/Nga mice. This study suggests that RA suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by reducing IFN-γ and IL-4 production by activated T cells and total serum IgE levels. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/21504802/Rosmarinic_acid_attenuates_24_dinitrofluorobenzene_induced_atopic_dermatitis_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(11)00180-9 DB - PRIME DP - Unbound Medicine ER -