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Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats.
Scand J Med Sci Sports. 2012 Dec; 22(6):764-75.SJ

Abstract

The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in rats subjected to exhaustive exercise. Rats were divided into sedentary control (SC), exhaustive exercise (EC) and exhaustive exercise with nutrient supplementation (EN). The nutrients include (mg/kg/day): R-α-lipoic acid 50, acetyl-L-carnitine 100, biotin 0.1, nicotinamide 15, riboflavin 6, pyridoxine 6, creatine 50, CoQ10 5, resveratrol 5 and taurine 100. Examination of running distances over the 4-week period revealed that EN rats ran significantly longer throughout the entire duration of the exhaustive exercise period compared with the EC rats. Nutrient supplementation significantly inhibited the increase in activities of alanine transaminase, lactate dehydrogenase and creatine kinase, reversed increases in malondialdehyde, inhibited decreases in glutathione S-transferase and total antioxidant capacity in plasma, and suppressed the elevation of reactive oxygen species and apoptosis in splenic lymphocytes. Nutrient supplementation increased the protein expression of mitochondrial complexes I, II and III, mtDNA number and transcription factors involved in mitochondrial biogenesis and fusion in skeletal muscle. These findings suggest that mitochondrial nutrient supplementation can reduce exhaustive exercise-induced oxidative damage and mitochondrial dysfunction, thus leading to enhancement of physical performance and of fatigue recovery.

Authors+Show Affiliations

Key Laboratory of General Administration of Sport, Shanghai Research Institute of Sports Science, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21507065

Citation

Sun, M, et al. "Mitochondrial Nutrients Stimulate Performance and Mitochondrial Biogenesis in Exhaustively Exercised Rats." Scandinavian Journal of Medicine & Science in Sports, vol. 22, no. 6, 2012, pp. 764-75.
Sun M, Qian F, Shen W, et al. Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. Scand J Med Sci Sports. 2012;22(6):764-75.
Sun, M., Qian, F., Shen, W., Tian, C., Hao, J., Sun, L., & Liu, J. (2012). Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. Scandinavian Journal of Medicine & Science in Sports, 22(6), 764-75. https://doi.org/10.1111/j.1600-0838.2011.01314.x
Sun M, et al. Mitochondrial Nutrients Stimulate Performance and Mitochondrial Biogenesis in Exhaustively Exercised Rats. Scand J Med Sci Sports. 2012;22(6):764-75. PubMed PMID: 21507065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats. AU - Sun,M, AU - Qian,F, AU - Shen,W, AU - Tian,C, AU - Hao,J, AU - Sun,L, AU - Liu,J, Y1 - 2011/04/21/ PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2013/5/17/medline SP - 764 EP - 75 JF - Scandinavian journal of medicine & science in sports JO - Scand J Med Sci Sports VL - 22 IS - 6 N2 - The aim of this study was to investigate the effects of a combination of nutrients on physical performance, oxidative stress and mitochondrial biogenesis in rats subjected to exhaustive exercise. Rats were divided into sedentary control (SC), exhaustive exercise (EC) and exhaustive exercise with nutrient supplementation (EN). The nutrients include (mg/kg/day): R-α-lipoic acid 50, acetyl-L-carnitine 100, biotin 0.1, nicotinamide 15, riboflavin 6, pyridoxine 6, creatine 50, CoQ10 5, resveratrol 5 and taurine 100. Examination of running distances over the 4-week period revealed that EN rats ran significantly longer throughout the entire duration of the exhaustive exercise period compared with the EC rats. Nutrient supplementation significantly inhibited the increase in activities of alanine transaminase, lactate dehydrogenase and creatine kinase, reversed increases in malondialdehyde, inhibited decreases in glutathione S-transferase and total antioxidant capacity in plasma, and suppressed the elevation of reactive oxygen species and apoptosis in splenic lymphocytes. Nutrient supplementation increased the protein expression of mitochondrial complexes I, II and III, mtDNA number and transcription factors involved in mitochondrial biogenesis and fusion in skeletal muscle. These findings suggest that mitochondrial nutrient supplementation can reduce exhaustive exercise-induced oxidative damage and mitochondrial dysfunction, thus leading to enhancement of physical performance and of fatigue recovery. SN - 1600-0838 UR - https://www.unboundmedicine.com/medline/citation/21507065/Mitochondrial_nutrients_stimulate_performance_and_mitochondrial_biogenesis_in_exhaustively_exercised_rats_ L2 - https://doi.org/10.1111/j.1600-0838.2011.01314.x DB - PRIME DP - Unbound Medicine ER -