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The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles.
Biomaterials. 2011 Jul; 32(21):4704-13.B

Abstract

Two types of magnetic binary nanocomposites, Ag@Fe(3)O(4) and γ-Fe(2)O(3)@Ag, were synthesized and characterized and their antibacterial activities were tested. As a magnetic component, Fe(3)O(4) (magnetite) nanoparticles with an average size of about 70 nm and monodisperse γ-Fe(2)O(3) (maghemite) nanoparticles with an average size of 5 nm were used. Nanocomposites were prepared via in situ chemical reduction of silver ions by maltose in the presence of particular magnetic phase and molecules of polyacrylate serving as a spacer among iron oxide and silver nanoparticles. In the case of the Ag@Fe(3)O(4) nanocomposite, silver nanoparticles, caught at the surfaces of Fe(3)O(4) nanocrystals, were around 5 nm in a size. On the contrary, in the case of the γ-Fe(2)O(3)@Ag nanocomposite, ultrafine γ-Fe(2)O(3) nanoparticles surrounded silver nanoparticles ranging in a size between 20 and 40 nm. In addition, the molecules of polyacrylate in this nanocomposite type suppress considerably interparticle magnetic interactions as proved by magnetization measurements. Both synthesized nanocomposites exhibited very significant antibacterial and antifungal activities against ten tested bacterial strains (minimum inhibition concentrations (MIC) from 15.6 mg/L to 125 mg/L) and four candida species (MIC from 1.9 mg/L to 31.3 mg/L). Moreover, acute nanocomposite cytotoxicity against mice embryonal fibroblasts was observed at concentrations of higher than 430 mg/L (Ag@Fe(3)O(4)) and 292 mg/L (γ-Fe(2)O(3)@Ag). With respect to the non-cytotoxic nature of the polyacrylate linker, both kinds of silver nanocomposites are well applicable for a targeted magnetic delivery of silver nanoparticles in medicinal and disinfection applications.

Authors+Show Affiliations

Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, Slechtitelu 11, 78371 Olomouc, Czech Republic. robert.prucek@upol.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21507482

Citation

Prucek, Robert, et al. "The Targeted Antibacterial and Antifungal Properties of Magnetic Nanocomposite of Iron Oxide and Silver Nanoparticles." Biomaterials, vol. 32, no. 21, 2011, pp. 4704-13.
Prucek R, Tuček J, Kilianová M, et al. The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles. Biomaterials. 2011;32(21):4704-13.
Prucek, R., Tuček, J., Kilianová, M., Panáček, A., Kvítek, L., Filip, J., Kolář, M., Tománková, K., & Zbořil, R. (2011). The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles. Biomaterials, 32(21), 4704-13. https://doi.org/10.1016/j.biomaterials.2011.03.039
Prucek R, et al. The Targeted Antibacterial and Antifungal Properties of Magnetic Nanocomposite of Iron Oxide and Silver Nanoparticles. Biomaterials. 2011;32(21):4704-13. PubMed PMID: 21507482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The targeted antibacterial and antifungal properties of magnetic nanocomposite of iron oxide and silver nanoparticles. AU - Prucek,Robert, AU - Tuček,Jiří, AU - Kilianová,Martina, AU - Panáček,Aleš, AU - Kvítek,Libor, AU - Filip,Jan, AU - Kolář,Milan, AU - Tománková,Kateřina, AU - Zbořil,Radek, Y1 - 2011/04/19/ PY - 2011/03/05/received PY - 2011/03/12/accepted PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2011/8/30/medline SP - 4704 EP - 13 JF - Biomaterials JO - Biomaterials VL - 32 IS - 21 N2 - Two types of magnetic binary nanocomposites, Ag@Fe(3)O(4) and γ-Fe(2)O(3)@Ag, were synthesized and characterized and their antibacterial activities were tested. As a magnetic component, Fe(3)O(4) (magnetite) nanoparticles with an average size of about 70 nm and monodisperse γ-Fe(2)O(3) (maghemite) nanoparticles with an average size of 5 nm were used. Nanocomposites were prepared via in situ chemical reduction of silver ions by maltose in the presence of particular magnetic phase and molecules of polyacrylate serving as a spacer among iron oxide and silver nanoparticles. In the case of the Ag@Fe(3)O(4) nanocomposite, silver nanoparticles, caught at the surfaces of Fe(3)O(4) nanocrystals, were around 5 nm in a size. On the contrary, in the case of the γ-Fe(2)O(3)@Ag nanocomposite, ultrafine γ-Fe(2)O(3) nanoparticles surrounded silver nanoparticles ranging in a size between 20 and 40 nm. In addition, the molecules of polyacrylate in this nanocomposite type suppress considerably interparticle magnetic interactions as proved by magnetization measurements. Both synthesized nanocomposites exhibited very significant antibacterial and antifungal activities against ten tested bacterial strains (minimum inhibition concentrations (MIC) from 15.6 mg/L to 125 mg/L) and four candida species (MIC from 1.9 mg/L to 31.3 mg/L). Moreover, acute nanocomposite cytotoxicity against mice embryonal fibroblasts was observed at concentrations of higher than 430 mg/L (Ag@Fe(3)O(4)) and 292 mg/L (γ-Fe(2)O(3)@Ag). With respect to the non-cytotoxic nature of the polyacrylate linker, both kinds of silver nanocomposites are well applicable for a targeted magnetic delivery of silver nanoparticles in medicinal and disinfection applications. SN - 1878-5905 UR - https://www.unboundmedicine.com/medline/citation/21507482/The_targeted_antibacterial_and_antifungal_properties_of_magnetic_nanocomposite_of_iron_oxide_and_silver_nanoparticles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0142-9612(11)00308-5 DB - PRIME DP - Unbound Medicine ER -