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Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population.
Int J Epidemiol 2011; 40(4):1047-55IJ

Abstract

BACKGROUND

The relationship between alcohol intake and the risk for gastric cancer is not fully understood. The association between alcohol consumption and the risk for gastric cancer was investigated in the Korean population with the ALDH2 genotype.

METHODS

From 2003 to 2008, 445 patients with gastric cancer and 370 control subjects ≥ 50 years of age were included in the analysis. Logistic regression models including age, gender, education, smoking and drinking status, Helicobacter pylori infection and ALDH2 genotype were evaluated to estimate the adjusted odds ratios (ORs) for the development of gastric cancer.

RESULTS

For all subjects, the risk for gastric cancer was increased in ex-drinkers [OR 1.68, 95% confidence interval (CI) 1.07-2.64], but not in current drinkers. Subjects with inactive ALDH2 *2 allele(s) showed a lower level of alcohol consumption than ALDH2 *1/*1 homozygotes (P < 0.001). Among the ALDH2 *1/*2 carriers (n = 243), current/ex-drinkers had a significantly increased risk for gastric cancer compared with never/rare drinkers (OR 2.80, 95% CI 1.51-5.19). Among heavy drinkers (n = 115), ALDH2 *1/*2 heterozygotes had a 4-fold increased risk for gastric cancer compared with *1/*1 homozygotes (OR 4.26, 95% CI 1.10-16.47); however, no risk increase was seen among never/rare drinkers.

CONCLUSIONS

A dose-response association between alcohol intake and the risk for gastric cancer was not observed. However, ALDH2 polymorphisms were found to modify the susceptibility to the development of gastric cancer associated with alcohol intake, especially in case of ALDH2 *1/*2 genotype. The findings suggest an alcohol-ALDH2 genotype interaction in gastric carcinogenesis.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21507992

Citation

Shin, Cheol Min, et al. "Association Between Alcohol Intake and Risk for Gastric Cancer With Regard to ALDH2 Genotype in the Korean Population." International Journal of Epidemiology, vol. 40, no. 4, 2011, pp. 1047-55.
Shin CM, Kim N, Cho SI, et al. Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population. Int J Epidemiol. 2011;40(4):1047-55.
Shin, C. M., Kim, N., Cho, S. I., Kim, J. S., Jung, H. C., & Song, I. S. (2011). Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population. International Journal of Epidemiology, 40(4), pp. 1047-55. doi:10.1093/ije/dyr067.
Shin CM, et al. Association Between Alcohol Intake and Risk for Gastric Cancer With Regard to ALDH2 Genotype in the Korean Population. Int J Epidemiol. 2011;40(4):1047-55. PubMed PMID: 21507992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population. AU - Shin,Cheol Min, AU - Kim,Nayoung, AU - Cho,Sung-Il, AU - Kim,Joo Sung, AU - Jung,Hyun Chae, AU - Song,In Sung, Y1 - 2011/04/19/ PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2012/1/26/medline SP - 1047 EP - 55 JF - International journal of epidemiology JO - Int J Epidemiol VL - 40 IS - 4 N2 - BACKGROUND: The relationship between alcohol intake and the risk for gastric cancer is not fully understood. The association between alcohol consumption and the risk for gastric cancer was investigated in the Korean population with the ALDH2 genotype. METHODS: From 2003 to 2008, 445 patients with gastric cancer and 370 control subjects ≥ 50 years of age were included in the analysis. Logistic regression models including age, gender, education, smoking and drinking status, Helicobacter pylori infection and ALDH2 genotype were evaluated to estimate the adjusted odds ratios (ORs) for the development of gastric cancer. RESULTS: For all subjects, the risk for gastric cancer was increased in ex-drinkers [OR 1.68, 95% confidence interval (CI) 1.07-2.64], but not in current drinkers. Subjects with inactive ALDH2 *2 allele(s) showed a lower level of alcohol consumption than ALDH2 *1/*1 homozygotes (P < 0.001). Among the ALDH2 *1/*2 carriers (n = 243), current/ex-drinkers had a significantly increased risk for gastric cancer compared with never/rare drinkers (OR 2.80, 95% CI 1.51-5.19). Among heavy drinkers (n = 115), ALDH2 *1/*2 heterozygotes had a 4-fold increased risk for gastric cancer compared with *1/*1 homozygotes (OR 4.26, 95% CI 1.10-16.47); however, no risk increase was seen among never/rare drinkers. CONCLUSIONS: A dose-response association between alcohol intake and the risk for gastric cancer was not observed. However, ALDH2 polymorphisms were found to modify the susceptibility to the development of gastric cancer associated with alcohol intake, especially in case of ALDH2 *1/*2 genotype. The findings suggest an alcohol-ALDH2 genotype interaction in gastric carcinogenesis. SN - 1464-3685 UR - https://www.unboundmedicine.com/medline/citation/21507992/Association_between_alcohol_intake_and_risk_for_gastric_cancer_with_regard_to_ALDH2_genotype_in_the_Korean_population_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyr067 DB - PRIME DP - Unbound Medicine ER -