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Serum carotenoids and risk of age-related macular degeneration in a chinese population sample.
Invest Ophthalmol Vis Sci 2011; 52(7):4338-44IO

Abstract

PURPOSE

It has been hypothesized that the macular carotenoids protect against age-related macular degeneration (AMD). In this study, the association between serum concentrations of carotenoids and the presence of AMD was evaluated in a case-control sample of elderly Chinese subjects.

METHODS

Two hundred sixty-three individuals aged between 50 and 88 years enrolled in the study. Subjects included 82 cases with exudative AMD, 92 cases with early AMD, and 89 control individuals. Serum carotenoids (lutein, zeaxanthin, lycopene, α- and β-carotenes, and β-cryptoxanthin) and retinol were measured with reversed-phase high-performance liquid chromatography (HPLC).

RESULTS

Serum levels of carotenoids and retinol were significantly lower in the cases with exudative AMD than in the controls. Median levels of lutein and zeaxanthin were 0.538 and 0.101 μM, respectively, in the control subjects, and 0.488 and 0.076 μM, respectively, in cases with exudative AMD. After adjustment for age, sex, smoking status, and body mass index (BMI), a significant inverse association was observed for exudative AMD with serum zeaxanthin (relative risk ratio [RRR], 0.04; 95% confidence interval [CI], 0-0.35), lycopene (RRR, 0.22; 95% CI, 0.1-0.48), and α-carotene (RRR, 0.24; 95% CI, 0.12-0.51). Early AMD was inversely associated only with lycopene (RRR, 0.49; 95% CI, 0.28-0.86) but was positively associated with α-carotene (RRR, 2.22; 95% CI, 1.37-3.58). No significant associations were observed between serum lutein and cases with early or exudative AMD.

CONCLUSIONS

The data suggest that higher levels of serum carotenoids, in particular zeaxanthin and lycopene, are associated with a lower likelihood of having exudative AMD. Serum levels of carotenoids were relatively higher in this Chinese cohort than in samples of other ethnicities in previous reports.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21508112

Citation

Zhou, Haiying, et al. "Serum Carotenoids and Risk of Age-related Macular Degeneration in a Chinese Population Sample." Investigative Ophthalmology & Visual Science, vol. 52, no. 7, 2011, pp. 4338-44.
Zhou H, Zhao X, Johnson EJ, et al. Serum carotenoids and risk of age-related macular degeneration in a chinese population sample. Invest Ophthalmol Vis Sci. 2011;52(7):4338-44.
Zhou, H., Zhao, X., Johnson, E. J., Lim, A., Sun, E., Yu, J., ... Liu, N. (2011). Serum carotenoids and risk of age-related macular degeneration in a chinese population sample. Investigative Ophthalmology & Visual Science, 52(7), pp. 4338-44. doi:10.1167/iovs.10-6519.
Zhou H, et al. Serum Carotenoids and Risk of Age-related Macular Degeneration in a Chinese Population Sample. Invest Ophthalmol Vis Sci. 2011 Jun 17;52(7):4338-44. PubMed PMID: 21508112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum carotenoids and risk of age-related macular degeneration in a chinese population sample. AU - Zhou,Haiying, AU - Zhao,Xianfeng, AU - Johnson,Elizabeth J, AU - Lim,Apiradee, AU - Sun,Erdan, AU - Yu,Jie, AU - Zhang,Yinbo, AU - Liu,Xipu, AU - Snellingen,Torkel, AU - Shang,Fu, AU - Liu,Ningpu, Y1 - 2011/06/17/ PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2011/8/17/medline SP - 4338 EP - 44 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 52 IS - 7 N2 - PURPOSE: It has been hypothesized that the macular carotenoids protect against age-related macular degeneration (AMD). In this study, the association between serum concentrations of carotenoids and the presence of AMD was evaluated in a case-control sample of elderly Chinese subjects. METHODS: Two hundred sixty-three individuals aged between 50 and 88 years enrolled in the study. Subjects included 82 cases with exudative AMD, 92 cases with early AMD, and 89 control individuals. Serum carotenoids (lutein, zeaxanthin, lycopene, α- and β-carotenes, and β-cryptoxanthin) and retinol were measured with reversed-phase high-performance liquid chromatography (HPLC). RESULTS: Serum levels of carotenoids and retinol were significantly lower in the cases with exudative AMD than in the controls. Median levels of lutein and zeaxanthin were 0.538 and 0.101 μM, respectively, in the control subjects, and 0.488 and 0.076 μM, respectively, in cases with exudative AMD. After adjustment for age, sex, smoking status, and body mass index (BMI), a significant inverse association was observed for exudative AMD with serum zeaxanthin (relative risk ratio [RRR], 0.04; 95% confidence interval [CI], 0-0.35), lycopene (RRR, 0.22; 95% CI, 0.1-0.48), and α-carotene (RRR, 0.24; 95% CI, 0.12-0.51). Early AMD was inversely associated only with lycopene (RRR, 0.49; 95% CI, 0.28-0.86) but was positively associated with α-carotene (RRR, 2.22; 95% CI, 1.37-3.58). No significant associations were observed between serum lutein and cases with early or exudative AMD. CONCLUSIONS: The data suggest that higher levels of serum carotenoids, in particular zeaxanthin and lycopene, are associated with a lower likelihood of having exudative AMD. Serum levels of carotenoids were relatively higher in this Chinese cohort than in samples of other ethnicities in previous reports. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/21508112/Serum_carotenoids_and_risk_of_age_related_macular_degeneration_in_a_chinese_population_sample_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.10-6519 DB - PRIME DP - Unbound Medicine ER -