Tags

Type your tag names separated by a space and hit enter

Lynch syndrome.
Clin Obstet Gynecol 2011; 54(2):199-214CO

Abstract

Almost 100 years ago Lynch syndrome was discovered by Dr Aldred Warthin. Initially, the syndrome was named Hereditary Nonpolyposis Colorectal Cancer as colorectal cancer seemed most prevalent. Over time uterine cancer and several other malignancies were recognized as part of the spectrum. This autosomal-dominant inherited cancer syndrome is characterized by a defect in mismatch repair genes and puts patients at a significantly increased risk for colorectal and uterine cancer. Recognition and diagnosis of Lynch syndrome is extremely important so that appropriate screening programs and/or risk-reducing surgery can be initiated to prevent development or promote early detection of cancers.

Authors+Show Affiliations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio 43204, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21508689

Citation

Backes, Floor J., and David E. Cohn. "Lynch Syndrome." Clinical Obstetrics and Gynecology, vol. 54, no. 2, 2011, pp. 199-214.
Backes FJ, Cohn DE. Lynch syndrome. Clin Obstet Gynecol. 2011;54(2):199-214.
Backes, F. J., & Cohn, D. E. (2011). Lynch syndrome. Clinical Obstetrics and Gynecology, 54(2), pp. 199-214. doi:10.1097/GRF.0b013e3182185a41.
Backes FJ, Cohn DE. Lynch Syndrome. Clin Obstet Gynecol. 2011;54(2):199-214. PubMed PMID: 21508689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lynch syndrome. AU - Backes,Floor J, AU - Cohn,David E, PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2011/10/15/medline SP - 199 EP - 214 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 54 IS - 2 N2 - Almost 100 years ago Lynch syndrome was discovered by Dr Aldred Warthin. Initially, the syndrome was named Hereditary Nonpolyposis Colorectal Cancer as colorectal cancer seemed most prevalent. Over time uterine cancer and several other malignancies were recognized as part of the spectrum. This autosomal-dominant inherited cancer syndrome is characterized by a defect in mismatch repair genes and puts patients at a significantly increased risk for colorectal and uterine cancer. Recognition and diagnosis of Lynch syndrome is extremely important so that appropriate screening programs and/or risk-reducing surgery can be initiated to prevent development or promote early detection of cancers. SN - 1532-5520 UR - https://www.unboundmedicine.com/medline/citation/21508689/Lynch_syndrome_ L2 - http://Insights.ovid.com/pubmed?pmid=21508689 DB - PRIME DP - Unbound Medicine ER -