Tags

Type your tag names separated by a space and hit enter

Lynch syndrome.

Abstract

Almost 100 years ago Lynch syndrome was discovered by Dr Aldred Warthin. Initially, the syndrome was named Hereditary Nonpolyposis Colorectal Cancer as colorectal cancer seemed most prevalent. Over time uterine cancer and several other malignancies were recognized as part of the spectrum. This autosomal-dominant inherited cancer syndrome is characterized by a defect in mismatch repair genes and puts patients at a significantly increased risk for colorectal and uterine cancer. Recognition and diagnosis of Lynch syndrome is extremely important so that appropriate screening programs and/or risk-reducing surgery can be initiated to prevent development or promote early detection of cancers.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, Ohio 43204, USA.

    Source

    Clinical obstetrics and gynecology 54:2 2011 Jun pg 199-214

    MeSH

    Colorectal Neoplasms, Hereditary Nonpolyposis
    Early Detection of Cancer
    Endometrial Neoplasms
    Female
    Humans
    Ovarian Neoplasms

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    21508689

    Citation

    Backes, Floor J., and David E. Cohn. "Lynch Syndrome." Clinical Obstetrics and Gynecology, vol. 54, no. 2, 2011, pp. 199-214.
    Backes FJ, Cohn DE. Lynch syndrome. Clin Obstet Gynecol. 2011;54(2):199-214.
    Backes, F. J., & Cohn, D. E. (2011). Lynch syndrome. Clinical Obstetrics and Gynecology, 54(2), pp. 199-214. doi:10.1097/GRF.0b013e3182185a41.
    Backes FJ, Cohn DE. Lynch Syndrome. Clin Obstet Gynecol. 2011;54(2):199-214. PubMed PMID: 21508689.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lynch syndrome. AU - Backes,Floor J, AU - Cohn,David E, PY - 2011/4/22/entrez PY - 2011/4/22/pubmed PY - 2011/10/15/medline SP - 199 EP - 214 JF - Clinical obstetrics and gynecology JO - Clin Obstet Gynecol VL - 54 IS - 2 N2 - Almost 100 years ago Lynch syndrome was discovered by Dr Aldred Warthin. Initially, the syndrome was named Hereditary Nonpolyposis Colorectal Cancer as colorectal cancer seemed most prevalent. Over time uterine cancer and several other malignancies were recognized as part of the spectrum. This autosomal-dominant inherited cancer syndrome is characterized by a defect in mismatch repair genes and puts patients at a significantly increased risk for colorectal and uterine cancer. Recognition and diagnosis of Lynch syndrome is extremely important so that appropriate screening programs and/or risk-reducing surgery can be initiated to prevent development or promote early detection of cancers. SN - 1532-5520 UR - https://www.unboundmedicine.com/medline/citation/21508689/Lynch_syndrome_ L2 - http://Insights.ovid.com/pubmed?pmid=21508689 DB - PRIME DP - Unbound Medicine ER -