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Primary graft dysfunction.
Clin Chest Med 2011; 32(2):279-93CC

Abstract

Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment.

Authors+Show Affiliations

Division of Pulmonary, Allergy and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. james.lee@uphs.upenn.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21511090

Citation

Lee, James C., and Jason D. Christie. "Primary Graft Dysfunction." Clinics in Chest Medicine, vol. 32, no. 2, 2011, pp. 279-93.
Lee JC, Christie JD. Primary graft dysfunction. Clin Chest Med. 2011;32(2):279-93.
Lee, J. C., & Christie, J. D. (2011). Primary graft dysfunction. Clinics in Chest Medicine, 32(2), pp. 279-93. doi:10.1016/j.ccm.2011.02.007.
Lee JC, Christie JD. Primary Graft Dysfunction. Clin Chest Med. 2011;32(2):279-93. PubMed PMID: 21511090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary graft dysfunction. AU - Lee,James C, AU - Christie,Jason D, PY - 2011/4/23/entrez PY - 2011/4/23/pubmed PY - 2011/8/16/medline SP - 279 EP - 93 JF - Clinics in chest medicine JO - Clin. Chest Med. VL - 32 IS - 2 N2 - Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis obliterans syndrome. This article aims to provide a state-of-the-art review of PGD epidemiology, outcomes, and risk factors, and to summarize current efforts at biomarker development and novel strategies for prevention and treatment. SN - 1557-8216 UR - https://www.unboundmedicine.com/medline/citation/21511090/Primary_graft_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-5231(11)00021-9 DB - PRIME DP - Unbound Medicine ER -