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Predisposing factors, disease progression and outcome in 430 prospectively followed patients of healthcare- and community-associated Staphylococcus aureus bacteraemia.
J Hosp Infect 2011; 78(2):102-7JH

Abstract

Staphylococcus aureus bacteraemia (SAB) episodes identified in a prospective multicentre study during 1999-2002 (not including MRSA) were followed up by an infectious disease specialist. The aim of this study was to compare predisposing factors, disease progression and outcome of healthcare (HA)- and community (CA)-associated SAB. Of 430 SAB episodes, 232 (54%) were HA. The HA-SAB patients were significantly older and more chronically ill compared to CA-SAB. Deep infection foci prevalence within three days of onset of SAB for HA versus CA were deep-seated abscesses (26% vs 37%, P < 0.05), pneumonia [25% vs 31%, non-significant (NS)], osteomyelitis (24% vs 36%, P<0.01), permanent foreign body (24% vs 9%, P<0.001), endocarditis (11% vs 15%, NS), septic arthritis (9% vs 13%, NS) and no infection focus (3% vs 6%, NS). The case fatality rates for HA-SAB versus CA-SAB at 28 days were 14% vs 11% (NS). Independent risk factors according to multivariate analysis for a fatal outcome were age, chronic alcoholism, immunosuppressive treatment, ultimately or rapidly fatal underlying diseases, severe sepsis on the onset of SAB, S. aureus pneumonia and endocarditis. As a result of a prospective study design, meticulous infection foci search and infectious disease specialist follow-up of each SAB episode, the case fatality remained low and 97% of the HA-SAB episodes presented infection foci within three days of onset of bacteraemia.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. erik.forsblom@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21511366

Citation

Forsblom, E, et al. "Predisposing Factors, Disease Progression and Outcome in 430 Prospectively Followed Patients of Healthcare- and Community-associated Staphylococcus Aureus Bacteraemia." The Journal of Hospital Infection, vol. 78, no. 2, 2011, pp. 102-7.
Forsblom E, Ruotsalainen E, Mölkänen T, et al. Predisposing factors, disease progression and outcome in 430 prospectively followed patients of healthcare- and community-associated Staphylococcus aureus bacteraemia. J Hosp Infect. 2011;78(2):102-7.
Forsblom, E., Ruotsalainen, E., Mölkänen, T., Ollgren, J., Lyytikäinen, O., & Järvinen, A. (2011). Predisposing factors, disease progression and outcome in 430 prospectively followed patients of healthcare- and community-associated Staphylococcus aureus bacteraemia. The Journal of Hospital Infection, 78(2), pp. 102-7. doi:10.1016/j.jhin.2011.03.010.
Forsblom E, et al. Predisposing Factors, Disease Progression and Outcome in 430 Prospectively Followed Patients of Healthcare- and Community-associated Staphylococcus Aureus Bacteraemia. J Hosp Infect. 2011;78(2):102-7. PubMed PMID: 21511366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predisposing factors, disease progression and outcome in 430 prospectively followed patients of healthcare- and community-associated Staphylococcus aureus bacteraemia. AU - Forsblom,E, AU - Ruotsalainen,E, AU - Mölkänen,T, AU - Ollgren,J, AU - Lyytikäinen,O, AU - Järvinen,A, Y1 - 2011/04/20/ PY - 2010/11/05/received PY - 2011/03/02/accepted PY - 2011/4/23/entrez PY - 2011/4/23/pubmed PY - 2011/9/29/medline SP - 102 EP - 7 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 78 IS - 2 N2 - Staphylococcus aureus bacteraemia (SAB) episodes identified in a prospective multicentre study during 1999-2002 (not including MRSA) were followed up by an infectious disease specialist. The aim of this study was to compare predisposing factors, disease progression and outcome of healthcare (HA)- and community (CA)-associated SAB. Of 430 SAB episodes, 232 (54%) were HA. The HA-SAB patients were significantly older and more chronically ill compared to CA-SAB. Deep infection foci prevalence within three days of onset of SAB for HA versus CA were deep-seated abscesses (26% vs 37%, P < 0.05), pneumonia [25% vs 31%, non-significant (NS)], osteomyelitis (24% vs 36%, P<0.01), permanent foreign body (24% vs 9%, P<0.001), endocarditis (11% vs 15%, NS), septic arthritis (9% vs 13%, NS) and no infection focus (3% vs 6%, NS). The case fatality rates for HA-SAB versus CA-SAB at 28 days were 14% vs 11% (NS). Independent risk factors according to multivariate analysis for a fatal outcome were age, chronic alcoholism, immunosuppressive treatment, ultimately or rapidly fatal underlying diseases, severe sepsis on the onset of SAB, S. aureus pneumonia and endocarditis. As a result of a prospective study design, meticulous infection foci search and infectious disease specialist follow-up of each SAB episode, the case fatality remained low and 97% of the HA-SAB episodes presented infection foci within three days of onset of bacteraemia. SN - 1532-2939 UR - https://www.unboundmedicine.com/medline/citation/21511366/Predisposing_factors_disease_progression_and_outcome_in_430_prospectively_followed_patients_of_healthcare__and_community_associated_Staphylococcus_aureus_bacteraemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(11)00121-6 DB - PRIME DP - Unbound Medicine ER -