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Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

Abstract

Amyloid-beta peptide (Aβ) is believed to be central in the pathogenesis of Alzheimer's disease (AD) characterized by cognitive deficits. However, it remains uncertain which form(s) of Aβ pathology is responsible for the cognitive deficits in AD. In the present study, the cognitive deficits and the profiles of Aβ pathology were characterized in the 12-month-old APPswe/PS1dE9 double transgenic mice, and their correlations were examined. Compared with non-transgenic littermates, the middle-aged APPswe/PS1dE9 mice exhibited spatial learning and memory deficits in the water maze test and long-term contextual memory deficits in the step-down passive avoidance test. Among the middle-aged APPswe/PS1dE9 mice, hippocampal soluble Aβ1-40 and Aβ1-42 levels were highly correlated with spatial learning deficits and long-term contextual memory deficits, as well as cortical and hippocampal soluble Aβ1-40 and Aβ1-42 levels were strongly correlated with spatial memory deficits. By contrast, no significant correlations were observed between three measures of cognitive functions and amyloid plaque burden (total Aβ plaque load and fibrillar Aβ plaque load), total Aβ levels (Aβ1-40 and Aβ1-42), as well as insoluble Aβ levels (Aβ1-40 and Aβ1-42). Stepwise multiple regression analysis identified hippocampal soluble Aβ1-40 and Aβ1-42 levels as independent factors for predicting the spatial learning deficits and the long-term contextual memory deficits, as well as hippocampal and cortical soluble Aβ1-40 and Aβ1-42 levels as independent factors for predicting the spatial memory deficits in transgenic mice. These results demonstrate that cognitive deficits are highly related to the levels of soluble Aβ in middle-aged APPswe/PS1dE9 mice, in which soluble Aβ levels are only a tiny fraction of the amount of total Aβ levels. Consequently, our findings provide further evidence that soluble Aβ might primarily contribute to cognitive deficits in AD, suggesting that reducing the levels of soluble Aβ species would be a therapeutic intervention for AD patients even with large deposits of aggregated, insoluble Aβ.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Fourth Military Medical University, Xi'an City, Shaanxi Province 710038, China.

    , , , , , ,

    Source

    Behavioural brain research 222:2 2011 Sep 23 pg 342-50

    MeSH

    Alzheimer Disease
    Amyloid beta-Peptides
    Amyloid beta-Protein Precursor
    Animals
    Avoidance Learning
    Cerebral Cortex
    Cognition Disorders
    Disease Models, Animal
    Female
    Hippocampus
    Maze Learning
    Mice
    Mice, Inbred C57BL
    Mice, Transgenic
    Presenilin-1
    Solubility

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21513747

    Citation

    Zhang, Wei, et al. "Soluble Aβ Levels Correlate With Cognitive Deficits in the 12-month-old APPswe/PS1dE9 Mouse Model of Alzheimer's Disease." Behavioural Brain Research, vol. 222, no. 2, 2011, pp. 342-50.
    Zhang W, Hao J, Liu R, et al. Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behav Brain Res. 2011;222(2):342-50.
    Zhang, W., Hao, J., Liu, R., Zhang, Z., Lei, G., Su, C., ... Li, Z. (2011). Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. Behavioural Brain Research, 222(2), pp. 342-50. doi:10.1016/j.bbr.2011.03.072.
    Zhang W, et al. Soluble Aβ Levels Correlate With Cognitive Deficits in the 12-month-old APPswe/PS1dE9 Mouse Model of Alzheimer's Disease. Behav Brain Res. 2011 Sep 23;222(2):342-50. PubMed PMID: 21513747.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease. AU - Zhang,Wei, AU - Hao,Jian, AU - Liu,Rui, AU - Zhang,Zhuo, AU - Lei,Gesheng, AU - Su,Changjun, AU - Miao,Jianting, AU - Li,Zhuyi, Y1 - 2011/04/14/ PY - 2010/12/08/received PY - 2011/03/25/revised PY - 2011/03/30/accepted PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/9/21/medline SP - 342 EP - 50 JF - Behavioural brain research JO - Behav. Brain Res. VL - 222 IS - 2 N2 - Amyloid-beta peptide (Aβ) is believed to be central in the pathogenesis of Alzheimer's disease (AD) characterized by cognitive deficits. However, it remains uncertain which form(s) of Aβ pathology is responsible for the cognitive deficits in AD. In the present study, the cognitive deficits and the profiles of Aβ pathology were characterized in the 12-month-old APPswe/PS1dE9 double transgenic mice, and their correlations were examined. Compared with non-transgenic littermates, the middle-aged APPswe/PS1dE9 mice exhibited spatial learning and memory deficits in the water maze test and long-term contextual memory deficits in the step-down passive avoidance test. Among the middle-aged APPswe/PS1dE9 mice, hippocampal soluble Aβ1-40 and Aβ1-42 levels were highly correlated with spatial learning deficits and long-term contextual memory deficits, as well as cortical and hippocampal soluble Aβ1-40 and Aβ1-42 levels were strongly correlated with spatial memory deficits. By contrast, no significant correlations were observed between three measures of cognitive functions and amyloid plaque burden (total Aβ plaque load and fibrillar Aβ plaque load), total Aβ levels (Aβ1-40 and Aβ1-42), as well as insoluble Aβ levels (Aβ1-40 and Aβ1-42). Stepwise multiple regression analysis identified hippocampal soluble Aβ1-40 and Aβ1-42 levels as independent factors for predicting the spatial learning deficits and the long-term contextual memory deficits, as well as hippocampal and cortical soluble Aβ1-40 and Aβ1-42 levels as independent factors for predicting the spatial memory deficits in transgenic mice. These results demonstrate that cognitive deficits are highly related to the levels of soluble Aβ in middle-aged APPswe/PS1dE9 mice, in which soluble Aβ levels are only a tiny fraction of the amount of total Aβ levels. Consequently, our findings provide further evidence that soluble Aβ might primarily contribute to cognitive deficits in AD, suggesting that reducing the levels of soluble Aβ species would be a therapeutic intervention for AD patients even with large deposits of aggregated, insoluble Aβ. SN - 1872-7549 UR - https://www.unboundmedicine.com/medline/citation/21513747/Soluble_Aβ_levels_correlate_with_cognitive_deficits_in_the_12_month_old_APPswe/PS1dE9_mouse_model_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(11)00295-6 DB - PRIME DP - Unbound Medicine ER -