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Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients.
Vaccine. 2011 Jun 06; 29(25):4187-9.V

Abstract

To assess the safety and immunogenicity of 2009 H1N1 influenza vaccination, 13 pediatric liver transplant recipients and 31 immunocompetent controls received inactivated influenza vaccine without adjuvant according to Japanese guidelines. Serious adverse events and acute allograft rejections were not observed in participants. Seroprotection rates (hemagglutinin-inhibition (HI) antibody titer ≥ 1:40) were 53.8% among recipients and 58.1% among controls (p=0.797). Seroconversion rates (4-fold or more HI antibody rise) were 46.2% for the recipient group and 51.6% for the control group (p=0.741). Geometric mean titers were elevated after vaccination in both groups. In comparison with the seasonal influenza vaccination, the seroconversion rate for 2009 H1N1 appeared to be higher than that for seasonal influenza antigens, and the seroprotection rate for 2009 H1N1 clearly increased after vaccination. These findings suggest that pediatric liver transplant patients may respond safely to inactivated 2009 H1N1 influenza vaccines in a manner similar to immunocompetent children.

Authors+Show Affiliations

Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21513762

Citation

Torii, Yuka, et al. "Immunogenicity of Inactivated 2009 H1N1 Influenza Vaccine in Pediatric Liver Transplant Recipients." Vaccine, vol. 29, no. 25, 2011, pp. 4187-9.
Torii Y, Kimura H, Ochi N, et al. Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. Vaccine. 2011;29(25):4187-9.
Torii, Y., Kimura, H., Ochi, N., Kaneko, K., Ando, H., Kiuchi, T., & Ito, Y. (2011). Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. Vaccine, 29(25), 4187-9. https://doi.org/10.1016/j.vaccine.2011.04.012
Torii Y, et al. Immunogenicity of Inactivated 2009 H1N1 Influenza Vaccine in Pediatric Liver Transplant Recipients. Vaccine. 2011 Jun 6;29(25):4187-9. PubMed PMID: 21513762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunogenicity of inactivated 2009 H1N1 influenza vaccine in pediatric liver transplant recipients. AU - Torii,Yuka, AU - Kimura,Hiroshi, AU - Ochi,Nobuhiko, AU - Kaneko,Kenitiro, AU - Ando,Hisami, AU - Kiuchi,Tetsuya, AU - Ito,Yoshinori, Y1 - 2011/04/20/ PY - 2010/10/25/received PY - 2011/02/26/revised PY - 2011/04/04/accepted PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/9/9/medline SP - 4187 EP - 9 JF - Vaccine JO - Vaccine VL - 29 IS - 25 N2 - To assess the safety and immunogenicity of 2009 H1N1 influenza vaccination, 13 pediatric liver transplant recipients and 31 immunocompetent controls received inactivated influenza vaccine without adjuvant according to Japanese guidelines. Serious adverse events and acute allograft rejections were not observed in participants. Seroprotection rates (hemagglutinin-inhibition (HI) antibody titer ≥ 1:40) were 53.8% among recipients and 58.1% among controls (p=0.797). Seroconversion rates (4-fold or more HI antibody rise) were 46.2% for the recipient group and 51.6% for the control group (p=0.741). Geometric mean titers were elevated after vaccination in both groups. In comparison with the seasonal influenza vaccination, the seroconversion rate for 2009 H1N1 appeared to be higher than that for seasonal influenza antigens, and the seroprotection rate for 2009 H1N1 clearly increased after vaccination. These findings suggest that pediatric liver transplant patients may respond safely to inactivated 2009 H1N1 influenza vaccines in a manner similar to immunocompetent children. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21513762/Immunogenicity_of_inactivated_2009_H1N1_influenza_vaccine_in_pediatric_liver_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00522-6 DB - PRIME DP - Unbound Medicine ER -