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Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential.
Neurosci Lett 2011; 496(1):60-4NL

Abstract

Numerous studies demonstrated a close relationship between cannabis abuse and schizophrenia with similar impairments in cognitive processing, particularly in P300 generation. Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. As previously reported, both acute oral Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive constituent of cannabis, and standardized cannabis extract containing Δ(9)-THC and cannabidiol (CBD) revealed a significant reduction of P300 amplitudes in healthy subjects but did not show any differences among each other. The aim of this study was to investigate whether the (AAT)n polymorphism differentially modulates the effects of Δ(9)-THC and cannabis extract on P300 generation in 20 healthy volunteers during an auditory choice reaction task. For the >10/>10 genotype, there was a significant decrease of P300 amplitude as well as a significant prolongation of P300 latency under pure Δ(9)-THC but not under cannabis extract. Moreover, we found a significant correlation between the number of AAT repeats and P300 variables for the Δ(9)-THC condition. Our data thus indicate that the CNR1 gene seems to be involved in the regulation of the P300 wave as a marker of selective attention and working memory. Moreover, it appears that variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on P300 generation in healthy subjects.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, Charité University Hospital Berlin, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21513772

Citation

Stadelmann, Andreas M., et al. "Association Between a Cannabinoid Receptor Gene (CNR1) Polymorphism and Cannabinoid-induced Alterations of the Auditory Event-related P300 Potential." Neuroscience Letters, vol. 496, no. 1, 2011, pp. 60-4.
Stadelmann AM, Juckel G, Arning L, et al. Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. Neurosci Lett. 2011;496(1):60-4.
Stadelmann, A. M., Juckel, G., Arning, L., Gallinat, J., Epplen, J. T., & Roser, P. (2011). Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. Neuroscience Letters, 496(1), pp. 60-4. doi:10.1016/j.neulet.2011.04.003.
Stadelmann AM, et al. Association Between a Cannabinoid Receptor Gene (CNR1) Polymorphism and Cannabinoid-induced Alterations of the Auditory Event-related P300 Potential. Neurosci Lett. 2011 May 27;496(1):60-4. PubMed PMID: 21513772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential. AU - Stadelmann,Andreas M, AU - Juckel,Georg, AU - Arning,Larissa, AU - Gallinat,Jürgen, AU - Epplen,Jörg T, AU - Roser,Patrik, Y1 - 2011/04/12/ PY - 2010/11/29/received PY - 2011/03/21/revised PY - 2011/04/05/accepted PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/8/30/medline SP - 60 EP - 4 JF - Neuroscience letters JO - Neurosci. Lett. VL - 496 IS - 1 N2 - Numerous studies demonstrated a close relationship between cannabis abuse and schizophrenia with similar impairments in cognitive processing, particularly in P300 generation. Recently, an (AAT)n triplet repeat polymorphism within the cannabinoid receptor gene CNR1 has been found to be associated with both schizophrenia and substance dependence, and to modulate the P300 potential. As previously reported, both acute oral Δ(9)-tetrahydrocannabinol (Δ(9)-THC), the main psychoactive constituent of cannabis, and standardized cannabis extract containing Δ(9)-THC and cannabidiol (CBD) revealed a significant reduction of P300 amplitudes in healthy subjects but did not show any differences among each other. The aim of this study was to investigate whether the (AAT)n polymorphism differentially modulates the effects of Δ(9)-THC and cannabis extract on P300 generation in 20 healthy volunteers during an auditory choice reaction task. For the >10/>10 genotype, there was a significant decrease of P300 amplitude as well as a significant prolongation of P300 latency under pure Δ(9)-THC but not under cannabis extract. Moreover, we found a significant correlation between the number of AAT repeats and P300 variables for the Δ(9)-THC condition. Our data thus indicate that the CNR1 gene seems to be involved in the regulation of the P300 wave as a marker of selective attention and working memory. Moreover, it appears that variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on P300 generation in healthy subjects. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/21513772/abstract/Association_between_a_cannabinoid_receptor_gene__CNR1__polymorphism_and_cannabinoid_induced_alterations_of_the_auditory_event_related_P300_potential_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(11)00437-X DB - PRIME DP - Unbound Medicine ER -