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Sustained virologic response with ribavirin in chronic hepatitis E virus infection in heart transplantation.
J Heart Lung Transplant. 2011 Jul; 30(7):841-3.JH

Abstract

Hepatitis E virus (HEV) is an emerging problem amongst transplant recipients. We report a patient with chronic HEV hepatitis after a heart transplant. The patient received a 3-month course of oral ribavirin (17 mg/kg/day). HEV RNA became undetectable in the serum after 1 month of treatment and remained undetectable in serum and stool samples until the last follow-up, 2 months after completion of ribavirin therapy. The values of liver function indicators returned to normal reference ranges. The main ribavirin-induced side effect was a significant but well-tolerated anemia. We confirmed that ribavirin may induce a sustained virologic response (4 months after ribavirin cessation) in heart transplant patients with chronic HEV infection. Liver cytolysis is rather common in patients after heart transplantation. Rapid evolution to liver fibrosis lesions and available anti-viral therapy highlight the need to look for HEV infection in heart transplant recipients with unexplained hepatitis.

Authors+Show Affiliations

Service de Bactériologie-Virologie, CHRU Bretonneau, Tours, France; INSERM U966 Université François-Rabelais de Tours, UFR Médecine, Tours, France. antoine.chaillon@univ-tours.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21515077

Citation

Chaillon, Antoine, et al. "Sustained Virologic Response With Ribavirin in Chronic Hepatitis E Virus Infection in Heart Transplantation." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, vol. 30, no. 7, 2011, pp. 841-3.
Chaillon A, Sirinelli A, De Muret A, et al. Sustained virologic response with ribavirin in chronic hepatitis E virus infection in heart transplantation. J Heart Lung Transplant. 2011;30(7):841-3.
Chaillon, A., Sirinelli, A., De Muret, A., Nicand, E., d'Alteroche, L., & Goudeau, A. (2011). Sustained virologic response with ribavirin in chronic hepatitis E virus infection in heart transplantation. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 30(7), 841-3. https://doi.org/10.1016/j.healun.2011.03.013
Chaillon A, et al. Sustained Virologic Response With Ribavirin in Chronic Hepatitis E Virus Infection in Heart Transplantation. J Heart Lung Transplant. 2011;30(7):841-3. PubMed PMID: 21515077.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained virologic response with ribavirin in chronic hepatitis E virus infection in heart transplantation. AU - Chaillon,Antoine, AU - Sirinelli,Agnès, AU - De Muret,Anne, AU - Nicand,Elisabeth, AU - d'Alteroche,Louis, AU - Goudeau,Alain, Y1 - 2011/04/22/ PY - 2010/11/13/received PY - 2011/03/09/revised PY - 2011/03/09/accepted PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/10/4/medline SP - 841 EP - 3 JF - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JO - J Heart Lung Transplant VL - 30 IS - 7 N2 - Hepatitis E virus (HEV) is an emerging problem amongst transplant recipients. We report a patient with chronic HEV hepatitis after a heart transplant. The patient received a 3-month course of oral ribavirin (17 mg/kg/day). HEV RNA became undetectable in the serum after 1 month of treatment and remained undetectable in serum and stool samples until the last follow-up, 2 months after completion of ribavirin therapy. The values of liver function indicators returned to normal reference ranges. The main ribavirin-induced side effect was a significant but well-tolerated anemia. We confirmed that ribavirin may induce a sustained virologic response (4 months after ribavirin cessation) in heart transplant patients with chronic HEV infection. Liver cytolysis is rather common in patients after heart transplantation. Rapid evolution to liver fibrosis lesions and available anti-viral therapy highlight the need to look for HEV infection in heart transplant recipients with unexplained hepatitis. SN - 1557-3117 UR - https://www.unboundmedicine.com/medline/citation/21515077/Sustained_virologic_response_with_ribavirin_in_chronic_hepatitis_E_virus_infection_in_heart_transplantation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-2498(11)00876-X DB - PRIME DP - Unbound Medicine ER -