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The influence of dissolution conditions on the drug ADME phenomena.
Eur J Pharm Biopharm. 2011 Oct; 79(2):382-91.EJ

Abstract

In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized.

Authors+Show Affiliations

Dipartimento di Ingegneria Industriale, Università degli Studi Salerno, Fisciano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21515367

Citation

Cascone, Sara, et al. "The Influence of Dissolution Conditions On the Drug ADME Phenomena." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 79, no. 2, 2011, pp. 382-91.
Cascone S, De Santis F, Lamberti G, et al. The influence of dissolution conditions on the drug ADME phenomena. Eur J Pharm Biopharm. 2011;79(2):382-91.
Cascone, S., De Santis, F., Lamberti, G., & Titomanlio, G. (2011). The influence of dissolution conditions on the drug ADME phenomena. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 79(2), 382-91. https://doi.org/10.1016/j.ejpb.2011.04.003
Cascone S, et al. The Influence of Dissolution Conditions On the Drug ADME Phenomena. Eur J Pharm Biopharm. 2011;79(2):382-91. PubMed PMID: 21515367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dissolution conditions on the drug ADME phenomena. AU - Cascone,Sara, AU - De Santis,Felice, AU - Lamberti,Gaetano, AU - Titomanlio,Giuseppe, Y1 - 2011/04/16/ PY - 2011/02/03/received PY - 2011/03/16/revised PY - 2011/04/08/accepted PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2012/4/12/medline SP - 382 EP - 91 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 79 IS - 2 N2 - In this work, a review of the apparatuses available to mimic what happens to a drug (or to foodstuffs) once ingested is presented. Similarly, a brief review of the models proposed to simulate the fate of a drug administered to a living body is reported. Then, the release kinetics of extended release of diclofenac from a commercial enteric-coated tablet was determined both in a conventional dissolution tester (USP Apparatus 2, Method A) as well as in an apparatus modified to reproduce a given pH evolution, closer to the real one than the one suggested by USP. The two experimental release profiles were reported and discussed; therefore, they were adopted as input functions for a previously proposed pharmacokinetic model. The obtained evolutions with time of plasma concentration were presented and used to assess the effectiveness of the commercial pharmaceutical products. The importance of a correct in vitro simulation for the design of pharmaceutical dosage systems was thus emphasized. SN - 1873-3441 UR - https://www.unboundmedicine.com/medline/citation/21515367/The_influence_of_dissolution_conditions_on_the_drug_ADME_phenomena_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(11)00141-X DB - PRIME DP - Unbound Medicine ER -