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Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women.
Int J STD AIDS. 2011 Apr; 22(4):209-13.IJ

Abstract

This study was undertaken to evaluate the prevalence of GB virus C (GBV-C) viraemia and anti-E2 antibody, and to assess the effect of co-infection with GBV-C and HIV during a 10-year follow-up of a cohort of 248 HIV-infected women. Laboratory variables (mean and median CD4 counts, and HIV and GBV-C viral loads) and clinical parameters were investigated. At baseline, 115 women had past exposure to GBV-C: 57 (23%) were GBV-C RNA positive and 58 (23%) were anti-E2 positive. There was no statistical difference between the groups (GBV-C RNA + /anti-E2 - , GBV-C RNA - /anti-E2 + and GBV-C RNA - /anti-E2 -) regarding baseline CD4 counts or HIV viral loads (P = 0.360 and 0.713, respectively). Relative risk of death for the GBV-C RNA + /anti-E2 - group was 63% lower than that for the GBV-C RNA - /anti-E2 - group. Multivariate analysis demonstrated that only HIV loads ≥ 100,000 copies/mL and AIDS-defining illness during follow-up were associated with shorter survival after AIDS development. It is likely that antiretroviral therapy (ART) use in our cohort blurred a putative protective effect related to the presence of GBV-C RNA.

Authors+Show Affiliations

Department of Infectious Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil. aleia@usp.brNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21515753

Citation

Campos, A F., et al. "Influence of Hepatitis G Virus (GB Virus C) On the Prognosis of HIV-infected Women." International Journal of STD & AIDS, vol. 22, no. 4, 2011, pp. 209-13.
Campos AF, Tengan FM, Silva SA, et al. Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women. Int J STD AIDS. 2011;22(4):209-13.
Campos, A. F., Tengan, F. M., Silva, S. A., & Levi, J. E. (2011). Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women. International Journal of STD & AIDS, 22(4), 209-13. https://doi.org/10.1258/ijsa.2011.010283
Campos AF, et al. Influence of Hepatitis G Virus (GB Virus C) On the Prognosis of HIV-infected Women. Int J STD AIDS. 2011;22(4):209-13. PubMed PMID: 21515753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hepatitis G virus (GB virus C) on the prognosis of HIV-infected women. AU - Campos,A F, AU - Tengan,F M, AU - Silva,S A A, AU - Levi,J E, PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/8/16/medline SP - 209 EP - 13 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 22 IS - 4 N2 - This study was undertaken to evaluate the prevalence of GB virus C (GBV-C) viraemia and anti-E2 antibody, and to assess the effect of co-infection with GBV-C and HIV during a 10-year follow-up of a cohort of 248 HIV-infected women. Laboratory variables (mean and median CD4 counts, and HIV and GBV-C viral loads) and clinical parameters were investigated. At baseline, 115 women had past exposure to GBV-C: 57 (23%) were GBV-C RNA positive and 58 (23%) were anti-E2 positive. There was no statistical difference between the groups (GBV-C RNA + /anti-E2 - , GBV-C RNA - /anti-E2 + and GBV-C RNA - /anti-E2 -) regarding baseline CD4 counts or HIV viral loads (P = 0.360 and 0.713, respectively). Relative risk of death for the GBV-C RNA + /anti-E2 - group was 63% lower than that for the GBV-C RNA - /anti-E2 - group. Multivariate analysis demonstrated that only HIV loads ≥ 100,000 copies/mL and AIDS-defining illness during follow-up were associated with shorter survival after AIDS development. It is likely that antiretroviral therapy (ART) use in our cohort blurred a putative protective effect related to the presence of GBV-C RNA. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/21515753/Influence_of_hepatitis_G_virus__GB_virus_C__on_the_prognosis_of_HIV_infected_women_ L2 - https://journals.sagepub.com/doi/10.1258/ijsa.2011.010283?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -