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Antioxidant therapy in male infertility: fact or fiction?
Asian J Androl 2011; 13(3):374-81AJ

Abstract

Infertile men have higher levels of semen reactive oxygen species (ROS) than do fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This observation has led clinicians to treat infertile men with antioxidant supplements. The purpose of this article is to discuss the rationale for antioxidant therapy in infertile men and to evaluate the data on the efficacy of dietary and in vitro antioxidant preparations on sperm function and DNA damage. To date, most clinical studies suggest that dietary antioxidant supplements are beneficial in terms of improving sperm function and DNA integrity. However, the exact mechanism of action of dietary antioxidants and the optimal dietary supplement have not been established. Moreover, most of the clinical studies are small and few have evaluated pregnancy rates. A beneficial effect of in vitro antioxidant supplements in protecting spermatozoa from exogenous oxidants has been demonstrated in most studies; however, the effect of these antioxidants in protecting sperm from endogenous ROS, gentle sperm processing and cryopreservation has not been established conclusively.

Authors+Show Affiliations

Division of Urology, Department of Surgery, Royal Victoria Hospital, McGill University, Montreal, Que. H3T 1M5, Canada. ziniarmand@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21516118

Citation

Zini, Armand, and Naif Al-Hathal. "Antioxidant Therapy in Male Infertility: Fact or Fiction?" Asian Journal of Andrology, vol. 13, no. 3, 2011, pp. 374-81.
Zini A, Al-Hathal N. Antioxidant therapy in male infertility: fact or fiction? Asian J Androl. 2011;13(3):374-81.
Zini, A., & Al-Hathal, N. (2011). Antioxidant therapy in male infertility: fact or fiction? Asian Journal of Andrology, 13(3), pp. 374-81. doi:10.1038/aja.2010.182.
Zini A, Al-Hathal N. Antioxidant Therapy in Male Infertility: Fact or Fiction. Asian J Androl. 2011;13(3):374-81. PubMed PMID: 21516118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant therapy in male infertility: fact or fiction? AU - Zini,Armand, AU - Al-Hathal,Naif, Y1 - 2011/04/25/ PY - 2011/4/26/entrez PY - 2011/4/26/pubmed PY - 2011/8/30/medline SP - 374 EP - 81 JF - Asian journal of andrology JO - Asian J. Androl. VL - 13 IS - 3 N2 - Infertile men have higher levels of semen reactive oxygen species (ROS) than do fertile men. High levels of semen ROS can cause sperm dysfunction, sperm DNA damage and reduced male reproductive potential. This observation has led clinicians to treat infertile men with antioxidant supplements. The purpose of this article is to discuss the rationale for antioxidant therapy in infertile men and to evaluate the data on the efficacy of dietary and in vitro antioxidant preparations on sperm function and DNA damage. To date, most clinical studies suggest that dietary antioxidant supplements are beneficial in terms of improving sperm function and DNA integrity. However, the exact mechanism of action of dietary antioxidants and the optimal dietary supplement have not been established. Moreover, most of the clinical studies are small and few have evaluated pregnancy rates. A beneficial effect of in vitro antioxidant supplements in protecting spermatozoa from exogenous oxidants has been demonstrated in most studies; however, the effect of these antioxidants in protecting sperm from endogenous ROS, gentle sperm processing and cryopreservation has not been established conclusively. SN - 1745-7262 UR - https://www.unboundmedicine.com/medline/citation/21516118/Antioxidant_therapy_in_male_infertility:_fact_or_fiction L2 - http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2010.182 DB - PRIME DP - Unbound Medicine ER -