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[Mitochondrial Na+-Ca2+-exchanger inhibitor CGP37157 produces endothelial cell depolarization with membrane potential oscillations].
Fiziol Zh. 2011; 57(1):9-16.FZ

Abstract

We explored the effect of inhibitor of mitochondrial Na(+)-Ca(2+)-exchanger CGP37157 and the effect of mitochondria permeability transition pore inhibitor, cyclosporine A, on the membrane potential and electrical responses to endothelium-dependent dilators in intact endothelial cells from excised rat aorta and EA.hy 926 endothelial cells. Cyclosporin A did not affect the resting membrane potential and hyperpolarization to acetylcholine and histamine in intact and cultured cells. In contrast, CGP37157 (20 mcM) evoked membrane depolarization in unstimulated cells and suppressed the sustained component of hyperpolarization to acetylcholine and histamine both in intact and cultured endothelial cells, respectively. This was accompanied by a pronounced depolarization with membrane potential oscillations, which were not observed in the absence of Ca2+. We conclude that CGP37157 modulates endothelial membrane potential at rest and electrical responses to endothelium-dependent dilators. Possible mechanisms accompanying the CGP37157 action are discussed.

Authors

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Pub Type(s)

English Abstract
Journal Article

Language

ukr

PubMed ID

21516829

Citation

Bondarenko, O I., and V F. Sahach. "[Mitochondrial Na+-Ca2+-exchanger Inhibitor CGP37157 Produces Endothelial Cell Depolarization With Membrane Potential Oscillations]." Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), vol. 57, no. 1, 2011, pp. 9-16.
Bondarenko OI, Sahach VF. [Mitochondrial Na+-Ca2+-exchanger inhibitor CGP37157 produces endothelial cell depolarization with membrane potential oscillations]. Fiziol Zh. 2011;57(1):9-16.
Bondarenko, O. I., & Sahach, V. F. (2011). [Mitochondrial Na+-Ca2+-exchanger inhibitor CGP37157 produces endothelial cell depolarization with membrane potential oscillations]. Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994), 57(1), 9-16.
Bondarenko OI, Sahach VF. [Mitochondrial Na+-Ca2+-exchanger Inhibitor CGP37157 Produces Endothelial Cell Depolarization With Membrane Potential Oscillations]. Fiziol Zh. 2011;57(1):9-16. PubMed PMID: 21516829.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Mitochondrial Na+-Ca2+-exchanger inhibitor CGP37157 produces endothelial cell depolarization with membrane potential oscillations]. AU - Bondarenko,O I, AU - Sahach,V F, PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2011/6/1/medline SP - 9 EP - 16 JF - Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) JO - Fiziol Zh VL - 57 IS - 1 N2 - We explored the effect of inhibitor of mitochondrial Na(+)-Ca(2+)-exchanger CGP37157 and the effect of mitochondria permeability transition pore inhibitor, cyclosporine A, on the membrane potential and electrical responses to endothelium-dependent dilators in intact endothelial cells from excised rat aorta and EA.hy 926 endothelial cells. Cyclosporin A did not affect the resting membrane potential and hyperpolarization to acetylcholine and histamine in intact and cultured cells. In contrast, CGP37157 (20 mcM) evoked membrane depolarization in unstimulated cells and suppressed the sustained component of hyperpolarization to acetylcholine and histamine both in intact and cultured endothelial cells, respectively. This was accompanied by a pronounced depolarization with membrane potential oscillations, which were not observed in the absence of Ca2+. We conclude that CGP37157 modulates endothelial membrane potential at rest and electrical responses to endothelium-dependent dilators. Possible mechanisms accompanying the CGP37157 action are discussed. SN - 2522-9028 UR - https://www.unboundmedicine.com/medline/citation/21516829/[Mitochondrial_Na+_Ca2+_exchanger_inhibitor_CGP37157_produces_endothelial_cell_depolarization_with_membrane_potential_oscillations]_ L2 - https://antibodies.cancer.gov/detail/CPTC-PIK3CA-1 DB - PRIME DP - Unbound Medicine ER -