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Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers.
J Agric Food Chem. 2011 Jun 08; 59(11):6025-33.JA

Abstract

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic-compound-guided separation. Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. In addition, the antiulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of antiulcer activity of adlay, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects.

Authors+Show Affiliations

Graduate Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21517098

Citation

Chung, Cheng-Pei, et al. "Gastroprotective Activities of Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) On the Growth of the Stomach Cancer AGS Cell Line and Indomethacin-induced Gastric Ulcers." Journal of Agricultural and Food Chemistry, vol. 59, no. 11, 2011, pp. 6025-33.
Chung CP, Hsia SM, Lee MY, et al. Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. J Agric Food Chem. 2011;59(11):6025-33.
Chung, C. P., Hsia, S. M., Lee, M. Y., Chen, H. J., Cheng, F., Chan, L. C., Kuo, Y. H., Lin, Y. L., & Chiang, W. (2011). Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. Journal of Agricultural and Food Chemistry, 59(11), 6025-33. https://doi.org/10.1021/jf2009556
Chung CP, et al. Gastroprotective Activities of Adlay (Coix Lachryma-jobi L. Var. Ma-yuen Stapf) On the Growth of the Stomach Cancer AGS Cell Line and Indomethacin-induced Gastric Ulcers. J Agric Food Chem. 2011 Jun 8;59(11):6025-33. PubMed PMID: 21517098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer AGS cell line and indomethacin-induced gastric ulcers. AU - Chung,Cheng-Pei, AU - Hsia,Shih-Min, AU - Lee,Ming-Yi, AU - Chen,Hong-Jhang, AU - Cheng,Faiwen, AU - Chan,Lu-Chi, AU - Kuo,Yueh-Hsiung, AU - Lin,Yun-Lian, AU - Chiang,Wenchang, Y1 - 2011/05/05/ PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2011/10/15/medline SP - 6025 EP - 33 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 59 IS - 11 N2 - Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic-compound-guided separation. Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. In addition, the antiulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of antiulcer activity of adlay, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/21517098/Gastroprotective_activities_of_adlay__Coix_lachryma_jobi_L__var__ma_yuen_Stapf__on_the_growth_of_the_stomach_cancer_AGS_cell_line_and_indomethacin_induced_gastric_ulcers_ L2 - https://doi.org/10.1021/jf2009556 DB - PRIME DP - Unbound Medicine ER -