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Meta-analysis of the relationship between the Metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer.
Asian Pac J Cancer Prev 2011; 12(1):247-52AP

Abstract

OBJECTIVE

To evaluate the effect of the methylenetetrahydrofolate reductase C677T genetic polymorphism (MTHFR C677T) and folate intake on the risk of esophageal cancer.

METHODS

A total of 17 studies (3,277 cases and 4,661 controls) regarding MTHFR C677T and 6 studies (1,817 cases and 7,678 controls) regarding folate intake published between 2001 and 2011 were identified through researching MEDLINE, EMBASE and the Chinese Biomedical Database. The data of the last search was February 2011. A meta-analysis was performed to obtain summary estimated odd ratios and 95% confidence intervals of folate intake and MTHFR C677T for esophageal cancer.

RESULTS

A significant association was seen between MTHFR 677 CT [adjusted OR (95% CI)=1.55(1.28-1.88)] and TT [crude OR (95% CI)=1.63(1.24-2.15)] genotypes and esophageal cancer. Folate intake was seen to have a preventive effect on esophageal cancer [OR (95% CI)=0.60(0.50-0.70)]. Non-drinkers with MTHFR 677 CT and TT showed light esophageal cancer risk, and higher esophageal cancer risk was found among smokers. Also, the MTHFR 677 CT and TT genotypes were associated with light esophageal cancer risk in non-drinkers and a higher risk in drinkers. The meta-regression analysis showed the effect of MTHFR 677 CT and TT increased with the level of alcohol and tobacco consumption. The MTHFR 677 TT genotype showed a decreased risk of esophageal cancer in the high folate intake group.

CONCLUSION

MTHFR 677CT/TT increase the risk of esophageal cancer, and the effects are greatly modified by alcohol, tobacco and folate intake. Folate intake was seen to have a preventive effect on developing esophageal cancer.

Authors+Show Affiliations

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21517266

Citation

Liu, Yi-Xia, et al. "Meta-analysis of the Relationship Between the Metholenetetrahydrofolate Reductase C677T Genetic Polymorphism, Folate Intake and Esophageal Cancer." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 12, no. 1, 2011, pp. 247-52.
Liu YX, Wang B, Wan MH, et al. Meta-analysis of the relationship between the Metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pac J Cancer Prev. 2011;12(1):247-52.
Liu, Y. X., Wang, B., Wan, M. H., Tang, W. F., Huang, F. K., & Li, C. (2011). Meta-analysis of the relationship between the Metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pacific Journal of Cancer Prevention : APJCP, 12(1), pp. 247-52.
Liu YX, et al. Meta-analysis of the Relationship Between the Metholenetetrahydrofolate Reductase C677T Genetic Polymorphism, Folate Intake and Esophageal Cancer. Asian Pac J Cancer Prev. 2011;12(1):247-52. PubMed PMID: 21517266.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of the relationship between the Metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. AU - Liu,Yi-Xia, AU - Wang,Bin, AU - Wan,Mei-Hua, AU - Tang,Wen-Fu, AU - Huang,Fu-Kai, AU - Li,Chengwen, PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2012/5/31/medline SP - 247 EP - 52 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 12 IS - 1 N2 - OBJECTIVE: To evaluate the effect of the methylenetetrahydrofolate reductase C677T genetic polymorphism (MTHFR C677T) and folate intake on the risk of esophageal cancer. METHODS: A total of 17 studies (3,277 cases and 4,661 controls) regarding MTHFR C677T and 6 studies (1,817 cases and 7,678 controls) regarding folate intake published between 2001 and 2011 were identified through researching MEDLINE, EMBASE and the Chinese Biomedical Database. The data of the last search was February 2011. A meta-analysis was performed to obtain summary estimated odd ratios and 95% confidence intervals of folate intake and MTHFR C677T for esophageal cancer. RESULTS: A significant association was seen between MTHFR 677 CT [adjusted OR (95% CI)=1.55(1.28-1.88)] and TT [crude OR (95% CI)=1.63(1.24-2.15)] genotypes and esophageal cancer. Folate intake was seen to have a preventive effect on esophageal cancer [OR (95% CI)=0.60(0.50-0.70)]. Non-drinkers with MTHFR 677 CT and TT showed light esophageal cancer risk, and higher esophageal cancer risk was found among smokers. Also, the MTHFR 677 CT and TT genotypes were associated with light esophageal cancer risk in non-drinkers and a higher risk in drinkers. The meta-regression analysis showed the effect of MTHFR 677 CT and TT increased with the level of alcohol and tobacco consumption. The MTHFR 677 TT genotype showed a decreased risk of esophageal cancer in the high folate intake group. CONCLUSION: MTHFR 677CT/TT increase the risk of esophageal cancer, and the effects are greatly modified by alcohol, tobacco and folate intake. Folate intake was seen to have a preventive effect on developing esophageal cancer. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/21517266/Meta_analysis_of_the_relationship_between_the_Metholenetetrahydrofolate_reductase_C677T_genetic_polymorphism_folate_intake_and_esophageal_cancer_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:21517266&key=2011.12.1.247 DB - PRIME DP - Unbound Medicine ER -