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Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study.
Acta Paediatr 2011; 100(10):1354-8AP

Abstract

AIM

Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction in AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM.

METHODS

Ninety-six children with an AOM onset before 6 months of age, implying a high risk for rAOM, were closely monitored until the age of 2 years. Forty-six were vaccinated with PCV7 and 50 were not. All episodes of AOM, emergency visits and ventilation tube insertions were registered.

RESULTS

A total of 363 AOM episodes were diagnosed. The incidence was reduced by 26% (p = 0.03), the number of emergency visits because of suspected AOM by 36% (p = 0.01) and the proportion of children who received ventilation tubes was halved in the vaccine group (p = 0.02).

CONCLUSIONS

During the first 2 years of life, PCV7 significantly reduced AOM episodes, emergency visits and ventilation tube insertions in children with rAOM. Pneumococcal vaccine may be a future route to reduce antibiotic use and health care consumption in otitis-prone children.

Authors+Show Affiliations

Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, Lund, Sweden. marie.solen@gmail.com

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21517964

Citation

Gisselsson-Solén, Marie, et al. "Pneumococcal Vaccination in Children at Risk of Developing Recurrent Acute Otitis Media - a Randomized Study." Acta Paediatrica (Oslo, Norway : 1992), vol. 100, no. 10, 2011, pp. 1354-8.
Gisselsson-Solén M, Melhus A, Hermansson A. Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study. Acta Paediatr. 2011;100(10):1354-8.
Gisselsson-Solén, M., Melhus, A., & Hermansson, A. (2011). Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study. Acta Paediatrica (Oslo, Norway : 1992), 100(10), pp. 1354-8. doi:10.1111/j.1651-2227.2011.02332.x.
Gisselsson-Solén M, Melhus A, Hermansson A. Pneumococcal Vaccination in Children at Risk of Developing Recurrent Acute Otitis Media - a Randomized Study. Acta Paediatr. 2011;100(10):1354-8. PubMed PMID: 21517964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study. AU - Gisselsson-Solén,Marie, AU - Melhus,Asa, AU - Hermansson,Ann, Y1 - 2011/05/27/ PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2012/3/30/medline SP - 1354 EP - 8 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 100 IS - 10 N2 - AIM: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction in AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM. METHODS: Ninety-six children with an AOM onset before 6 months of age, implying a high risk for rAOM, were closely monitored until the age of 2 years. Forty-six were vaccinated with PCV7 and 50 were not. All episodes of AOM, emergency visits and ventilation tube insertions were registered. RESULTS: A total of 363 AOM episodes were diagnosed. The incidence was reduced by 26% (p = 0.03), the number of emergency visits because of suspected AOM by 36% (p = 0.01) and the proportion of children who received ventilation tubes was halved in the vaccine group (p = 0.02). CONCLUSIONS: During the first 2 years of life, PCV7 significantly reduced AOM episodes, emergency visits and ventilation tube insertions in children with rAOM. Pneumococcal vaccine may be a future route to reduce antibiotic use and health care consumption in otitis-prone children. SN - 1651-2227 UR - https://www.unboundmedicine.com/medline/citation/21517964/Pneumococcal_vaccination_in_children_at_risk_of_developing_recurrent_acute_otitis_media___a_randomized_study_ L2 - https://doi.org/10.1111/j.1651-2227.2011.02332.x DB - PRIME DP - Unbound Medicine ER -