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Variability of pulse wave velocity and mortality in chronic hemodialysis patients.
Hemodial Int. 2011 Jul; 15(3):326-33.HI

Abstract

We have already demonstrated that in chronic hemodialysis (HD) patients, the cyclic variations in both hydration status and blood pressure are responsible for changes in pulse wave velocity (PWV). The aim of this study is to verify whether the cyclic variation of PWV influences mortality in dialysis patients. We studied 167 oligoanuric (urinary output <500 mL/day) patients on chronic standard bicarbonate HD for at least 6 months. They performed 3 HD sessions of 4 hours per week. Patients were classified into 3 groups: normal PWV before and after dialysis (LL); high PWV before and normal PWV after dialysis (HL); and high PWV before and after dialysis (HH). The carotid-femoral PWV was measured with an automated system using the foot-to-foot method. Analysis of variance was used to compare the different groups. The outcome event studied was all-cause mortality and cardiovascular mortality. The PWV values observed were LL in 44 patients (26.3%); HL in 53 patients (31.8%); and HH in 70 patients (41.9%). The 3 groups of patients are homogenous for sex, age, and blood pressure. The HH group had a higher prevalence of (P<0.001) ASCVD. It is interesting that the distribution of patients in the 3 groups is correlated with the basal value of PWV. In fact, when the basal measure of PWV is elevated, there is a higher probability that an HD session cannot reduce PWV (<12 ms). A total of 53 patients (31.7%) died during the follow-up of 2 years: 5 patients in the LL group (11.4%); 16 in the HL group (30.2%); and 32 in the HH group (50.7%) (LL vs. HL, P=0.047; LL vs. HH, P<0.00001; HL vs. HH, P=0.034). We evidence for the first time that different behaviors of PWV in dialysis subjects determine differences in mortality.

Authors+Show Affiliations

SOC di Nefrologia, Solofra, Avellino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

21518244

Citation

Torraca, Serena, et al. "Variability of Pulse Wave Velocity and Mortality in Chronic Hemodialysis Patients." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 15, no. 3, 2011, pp. 326-33.
Torraca S, Sirico ML, Guastaferro P, et al. Variability of pulse wave velocity and mortality in chronic hemodialysis patients. Hemodial Int. 2011;15(3):326-33.
Torraca, S., Sirico, M. L., Guastaferro, P., Morrone, L. F., Nigro, F., Blasio, A. D., Romano, P., Russo, D., Bellasi, A., & Di Iorio, B. (2011). Variability of pulse wave velocity and mortality in chronic hemodialysis patients. Hemodialysis International. International Symposium On Home Hemodialysis, 15(3), 326-33. https://doi.org/10.1111/j.1542-4758.2011.00545.x
Torraca S, et al. Variability of Pulse Wave Velocity and Mortality in Chronic Hemodialysis Patients. Hemodial Int. 2011;15(3):326-33. PubMed PMID: 21518244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variability of pulse wave velocity and mortality in chronic hemodialysis patients. AU - Torraca,Serena, AU - Sirico,Maria Luisa, AU - Guastaferro,Pasquale, AU - Morrone,Luigi Francesco, AU - Nigro,Filippo, AU - Blasio,Antonietta De, AU - Romano,Paolo, AU - Russo,Domenico, AU - Bellasi,Antonio, AU - Di Iorio,Biagio, Y1 - 2011/04/25/ PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2011/10/25/medline SP - 326 EP - 33 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 15 IS - 3 N2 - We have already demonstrated that in chronic hemodialysis (HD) patients, the cyclic variations in both hydration status and blood pressure are responsible for changes in pulse wave velocity (PWV). The aim of this study is to verify whether the cyclic variation of PWV influences mortality in dialysis patients. We studied 167 oligoanuric (urinary output <500 mL/day) patients on chronic standard bicarbonate HD for at least 6 months. They performed 3 HD sessions of 4 hours per week. Patients were classified into 3 groups: normal PWV before and after dialysis (LL); high PWV before and normal PWV after dialysis (HL); and high PWV before and after dialysis (HH). The carotid-femoral PWV was measured with an automated system using the foot-to-foot method. Analysis of variance was used to compare the different groups. The outcome event studied was all-cause mortality and cardiovascular mortality. The PWV values observed were LL in 44 patients (26.3%); HL in 53 patients (31.8%); and HH in 70 patients (41.9%). The 3 groups of patients are homogenous for sex, age, and blood pressure. The HH group had a higher prevalence of (P<0.001) ASCVD. It is interesting that the distribution of patients in the 3 groups is correlated with the basal value of PWV. In fact, when the basal measure of PWV is elevated, there is a higher probability that an HD session cannot reduce PWV (<12 ms). A total of 53 patients (31.7%) died during the follow-up of 2 years: 5 patients in the LL group (11.4%); 16 in the HL group (30.2%); and 32 in the HH group (50.7%) (LL vs. HL, P=0.047; LL vs. HH, P<0.00001; HL vs. HH, P=0.034). We evidence for the first time that different behaviors of PWV in dialysis subjects determine differences in mortality. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/21518244/Variability_of_pulse_wave_velocity_and_mortality_in_chronic_hemodialysis_patients_ L2 - https://doi.org/10.1111/j.1542-4758.2011.00545.x DB - PRIME DP - Unbound Medicine ER -