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The relationship among TAFI, t-PA, PAI-1 and F1 + 2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria.
Blood Coagul Fibrinolysis. 2011 Sep; 22(6):493-8.BC

Abstract

Disturbances of coagulation and fibrinolysis in type 2 diabetes mellitus (DM2) contribute to increased rates of macrovascular complications such as myocardial infarction and ischemic stroke. The aim of the study was to investigate the relationship among plasminogen activator inhibitor 1 (PAI-1), thrombin-activable fibrinolysis inhibitor (TAFI), tissue plasminogen activator (t-PA), prothrombin fragments 1+2 (F1+2), glycemic control, hypertension, sex and body mass index (BMI) in DM2 patients with normoalbuminuria and microalbuminuria. Forty-two normoalbuminuric (NAU), 42 microalbuminuric (MAU) patients with DM2 and 42 blood donors as control group were enrolled. TAFI, PAI-1, t-PA and F1+2 were assessed by enzyme-linked immunosorbent assay (ELISA) in all patients. TAFI was significantly increased in the MAU group, PAI-1 and F1+2 were increased in both groups and t-PA was not elevated in either group compared to controls. We found positive correlations in the NAU: TAFI and fibrinogen (r=0.65, P=0.02), PAI-1 and triglycerides (r=0.67, P=0.01), in the MAU: TAFI and F1+2 (r=0.48, P=0.02), TAFI and systolic blood pressure (r=0.53, P=0.01), PAI-1 and BMI (r=0.43, P<0.05). We found decreased fibrinolysis in DM2 patients presented with increased PAI-1 in both NAU and MAU. Hypofibrinolysis in MAU is further accented by the elevation of TAFI. TAFI-mediated inhibition of fibrinolysis in DM2 is regulated independently from PAI-1. Patient[Combining Acute Accent]s sex does not affect diabetes-related changes in hemostasis and fibrinolysis.

Authors+Show Affiliations

National Center of Hemostasis and Thrombosis, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. chudy@jfmed.uniba.skNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21519232

Citation

Chudý, Peter, et al. "The Relationship Among TAFI, t-PA, PAI-1 and F1 + 2 in Type 2 Diabetic Patients With Normoalbuminuria and Microalbuminuria." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 22, no. 6, 2011, pp. 493-8.
Chudý P, Kotuličová D, Staško J, et al. The relationship among TAFI, t-PA, PAI-1 and F1 + 2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria. Blood Coagul Fibrinolysis. 2011;22(6):493-8.
Chudý, P., Kotuličová, D., Staško, J., & Kubisz, P. (2011). The relationship among TAFI, t-PA, PAI-1 and F1 + 2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 22(6), 493-8. https://doi.org/10.1097/MBC.0b013e328346f8ca
Chudý P, et al. The Relationship Among TAFI, t-PA, PAI-1 and F1 + 2 in Type 2 Diabetic Patients With Normoalbuminuria and Microalbuminuria. Blood Coagul Fibrinolysis. 2011;22(6):493-8. PubMed PMID: 21519232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship among TAFI, t-PA, PAI-1 and F1 + 2 in type 2 diabetic patients with normoalbuminuria and microalbuminuria. AU - Chudý,Peter, AU - Kotuličová,Daniela, AU - Staško,Ján, AU - Kubisz,Peter, PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2011/12/13/medline SP - 493 EP - 8 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul Fibrinolysis VL - 22 IS - 6 N2 - Disturbances of coagulation and fibrinolysis in type 2 diabetes mellitus (DM2) contribute to increased rates of macrovascular complications such as myocardial infarction and ischemic stroke. The aim of the study was to investigate the relationship among plasminogen activator inhibitor 1 (PAI-1), thrombin-activable fibrinolysis inhibitor (TAFI), tissue plasminogen activator (t-PA), prothrombin fragments 1+2 (F1+2), glycemic control, hypertension, sex and body mass index (BMI) in DM2 patients with normoalbuminuria and microalbuminuria. Forty-two normoalbuminuric (NAU), 42 microalbuminuric (MAU) patients with DM2 and 42 blood donors as control group were enrolled. TAFI, PAI-1, t-PA and F1+2 were assessed by enzyme-linked immunosorbent assay (ELISA) in all patients. TAFI was significantly increased in the MAU group, PAI-1 and F1+2 were increased in both groups and t-PA was not elevated in either group compared to controls. We found positive correlations in the NAU: TAFI and fibrinogen (r=0.65, P=0.02), PAI-1 and triglycerides (r=0.67, P=0.01), in the MAU: TAFI and F1+2 (r=0.48, P=0.02), TAFI and systolic blood pressure (r=0.53, P=0.01), PAI-1 and BMI (r=0.43, P<0.05). We found decreased fibrinolysis in DM2 patients presented with increased PAI-1 in both NAU and MAU. Hypofibrinolysis in MAU is further accented by the elevation of TAFI. TAFI-mediated inhibition of fibrinolysis in DM2 is regulated independently from PAI-1. Patient[Combining Acute Accent]s sex does not affect diabetes-related changes in hemostasis and fibrinolysis. SN - 1473-5733 UR - https://www.unboundmedicine.com/medline/citation/21519232/The_relationship_among_TAFI_t_PA_PAI_1_and_F1_+_2_in_type_2_diabetic_patients_with_normoalbuminuria_and_microalbuminuria_ L2 - https://doi.org/10.1097/MBC.0b013e328346f8ca DB - PRIME DP - Unbound Medicine ER -