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Extinction learning of rewards in the rat: is there a role for CB1 receptors?
Psychopharmacology (Berl). 2011 Sep; 217(2):189-97.P

Abstract

RATIONALE

Endocannabinoids have been widely studied in the context of addiction and reward due to their role in reinstatement. However, little is known about the role of CB1 receptors during extinction learning of an appetitively motivated task.

OBJECTIVE

The aim of this study was to evaluate the role of endocannabinoids at different stages of extinction learning.

METHODS

Endocannabinoid signaling was disrupted by injecting the CB1 receptor antagonist rimonabant (0, 200, 300 μg/kg i.v.) during the acquisition or consolidation phases of learning. The rate of extinction and its half-life were analyzed, as well as food-seeking in a reward-induced reinstatement test. We further investigated the interaction between extinction and endocannabinoids in different groups of rats that received drug treatments but did not undergo extinction training (abstinence). In addition, the effects of rimonabant on cue retrieval were investigated in a cue-induced reinstatement test in which rimonabant (0, 300 μg/kg i.v.) was given immediately prior to the reinstatement session.

RESULTS

Blockade of CB1 receptors during acquisition or consolidation of extinction learning had no effect on the rate extinction or its half-life and these pretreatments had no long term consequences on reward-seeking behavior. Furthermore, rats that underwent extinction training responded at lower levels than those that received the drug in the absence of extinction (p = 0.000, η (2) = 0.40). Rimonabant was effective in inhibiting behavior only if it was immediately given before a cue-induced reinstatement session (p = 0.000, η (2) = 0.92).

CONCLUSION

The present results clarify and isolate the role of endocannabinoids in reinstatement as key mediators of cue retrieval, rather than orchestrators of extinction learning processes.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 2120, USA. giovannih@umaryland.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

21519986

Citation

Hernandez, Giovanni, and Joseph F. Cheer. "Extinction Learning of Rewards in the Rat: Is There a Role for CB1 Receptors?" Psychopharmacology, vol. 217, no. 2, 2011, pp. 189-97.
Hernandez G, Cheer JF. Extinction learning of rewards in the rat: is there a role for CB1 receptors? Psychopharmacology (Berl). 2011;217(2):189-97.
Hernandez, G., & Cheer, J. F. (2011). Extinction learning of rewards in the rat: is there a role for CB1 receptors? Psychopharmacology, 217(2), 189-97. https://doi.org/10.1007/s00213-011-2275-7
Hernandez G, Cheer JF. Extinction Learning of Rewards in the Rat: Is There a Role for CB1 Receptors. Psychopharmacology (Berl). 2011;217(2):189-97. PubMed PMID: 21519986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extinction learning of rewards in the rat: is there a role for CB1 receptors? AU - Hernandez,Giovanni, AU - Cheer,Joseph F, Y1 - 2011/04/27/ PY - 2010/11/10/received PY - 2011/03/15/accepted PY - 2011/4/27/entrez PY - 2011/4/27/pubmed PY - 2012/1/4/medline SP - 189 EP - 97 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 217 IS - 2 N2 - RATIONALE: Endocannabinoids have been widely studied in the context of addiction and reward due to their role in reinstatement. However, little is known about the role of CB1 receptors during extinction learning of an appetitively motivated task. OBJECTIVE: The aim of this study was to evaluate the role of endocannabinoids at different stages of extinction learning. METHODS: Endocannabinoid signaling was disrupted by injecting the CB1 receptor antagonist rimonabant (0, 200, 300 μg/kg i.v.) during the acquisition or consolidation phases of learning. The rate of extinction and its half-life were analyzed, as well as food-seeking in a reward-induced reinstatement test. We further investigated the interaction between extinction and endocannabinoids in different groups of rats that received drug treatments but did not undergo extinction training (abstinence). In addition, the effects of rimonabant on cue retrieval were investigated in a cue-induced reinstatement test in which rimonabant (0, 300 μg/kg i.v.) was given immediately prior to the reinstatement session. RESULTS: Blockade of CB1 receptors during acquisition or consolidation of extinction learning had no effect on the rate extinction or its half-life and these pretreatments had no long term consequences on reward-seeking behavior. Furthermore, rats that underwent extinction training responded at lower levels than those that received the drug in the absence of extinction (p = 0.000, η (2) = 0.40). Rimonabant was effective in inhibiting behavior only if it was immediately given before a cue-induced reinstatement session (p = 0.000, η (2) = 0.92). CONCLUSION: The present results clarify and isolate the role of endocannabinoids in reinstatement as key mediators of cue retrieval, rather than orchestrators of extinction learning processes. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21519986/Extinction_learning_of_rewards_in_the_rat:_is_there_a_role_for_CB1_receptors L2 - https://dx.doi.org/10.1007/s00213-011-2275-7 DB - PRIME DP - Unbound Medicine ER -