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Postnatal growth and cardiometabolic profile in young adults born large for gestational age.
Clin Endocrinol (Oxf) 2011; 75(3):335-41CE

Abstract

CONTEXT

The association between large for gestational age (LGA) phenotype, postnatal growth and cardiometabolic risk (CMR) in adult life remains unclear. The role of IGF1 genotype on LGA-related outcomes in adult life is unknown.

AIM

To assess the postnatal growth, IGF-I levels, CMR and the influence of the 737.738 IGF1 in adults born LGA.

SUBJECTS

Case-control study (n = 515) nested in a population-based prospective cohort (n = 2063); 117 LGA and 398 gender-matched controls appropriate for gestational age (AGA) subjects.

METHODS

Anthropometry was evaluated at birth, at 9-10 and at 23-25 years old. At the age of 23-25 years, blood pressure (BP), glycaemia, insulinaemia, homeostasis model assessment - insulin resistance, lipids, fibrinogen, and plasma IGF-I and 737.738 IGF1 polymorphism were assessed.

RESULTS

Large for gestational age subjects remained heavier and taller than AGA at 9-10 and 23-25 years (P < 0·05); at 23-25 years, LGA had greater waist circumference (WC; P < 0·05) and higher BP (P < 0·05) than controls. Body proportionality at birth did not predict metabolic outcome. LGA subjects presenting catch-down of weight in childhood had lower body mass index (BMI; P = 0·001), lower WC (P < 0·05) and lower BP (P < 0·05) at 23-25 years. 737.738 IGF-I genotype differed between groups (P < 0·001). Homozygosis for polymorphic alleles was associated with increased odds of LGA (OR: 3·2; 95% CI: 1·5-6·9), higher IGF-I (56·9 ± 16·4 vs 37·7 ± 16·0 nm; P < 0·01) and lower BP (114/68 vs 121/73 mmHg; P < 0·05).

CONCLUSIONS

Young adults born LGA presented higher BMI, WC and BP and appear to be at higher CMR risk than AGA subjects. The 737.738 IGF1 polymorphism appears to play a role on birth size and LGA-related metabolic outcomes.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21521322

Citation

Renom Espineira, Aniette, et al. "Postnatal Growth and Cardiometabolic Profile in Young Adults Born Large for Gestational Age." Clinical Endocrinology, vol. 75, no. 3, 2011, pp. 335-41.
Renom Espineira A, Fernandes-Rosa FL, Bueno AC, et al. Postnatal growth and cardiometabolic profile in young adults born large for gestational age. Clin Endocrinol (Oxf). 2011;75(3):335-41.
Renom Espineira, A., Fernandes-Rosa, F. L., Bueno, A. C., de Souza, R. M., Moreira, A. C., de Castro, M., ... Antonini, S. R. (2011). Postnatal growth and cardiometabolic profile in young adults born large for gestational age. Clinical Endocrinology, 75(3), pp. 335-41. doi:10.1111/j.1365-2265.2011.04054.x.
Renom Espineira A, et al. Postnatal Growth and Cardiometabolic Profile in Young Adults Born Large for Gestational Age. Clin Endocrinol (Oxf). 2011;75(3):335-41. PubMed PMID: 21521322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postnatal growth and cardiometabolic profile in young adults born large for gestational age. AU - Renom Espineira,Aniette, AU - Fernandes-Rosa,Fábio Luiz, AU - Bueno,Ana Carolina, AU - de Souza,Roberto Molina, AU - Moreira,Ayrton Custódio, AU - de Castro,Margaret, AU - Barbieri,Marco Antonio, AU - Bettiol,Heloísa, AU - Antonini,Sonir Rauber, PY - 2011/4/28/entrez PY - 2011/4/28/pubmed PY - 2012/1/26/medline SP - 335 EP - 41 JF - Clinical endocrinology JO - Clin. Endocrinol. (Oxf) VL - 75 IS - 3 N2 - CONTEXT: The association between large for gestational age (LGA) phenotype, postnatal growth and cardiometabolic risk (CMR) in adult life remains unclear. The role of IGF1 genotype on LGA-related outcomes in adult life is unknown. AIM: To assess the postnatal growth, IGF-I levels, CMR and the influence of the 737.738 IGF1 in adults born LGA. SUBJECTS: Case-control study (n = 515) nested in a population-based prospective cohort (n = 2063); 117 LGA and 398 gender-matched controls appropriate for gestational age (AGA) subjects. METHODS: Anthropometry was evaluated at birth, at 9-10 and at 23-25 years old. At the age of 23-25 years, blood pressure (BP), glycaemia, insulinaemia, homeostasis model assessment - insulin resistance, lipids, fibrinogen, and plasma IGF-I and 737.738 IGF1 polymorphism were assessed. RESULTS: Large for gestational age subjects remained heavier and taller than AGA at 9-10 and 23-25 years (P < 0·05); at 23-25 years, LGA had greater waist circumference (WC; P < 0·05) and higher BP (P < 0·05) than controls. Body proportionality at birth did not predict metabolic outcome. LGA subjects presenting catch-down of weight in childhood had lower body mass index (BMI; P = 0·001), lower WC (P < 0·05) and lower BP (P < 0·05) at 23-25 years. 737.738 IGF-I genotype differed between groups (P < 0·001). Homozygosis for polymorphic alleles was associated with increased odds of LGA (OR: 3·2; 95% CI: 1·5-6·9), higher IGF-I (56·9 ± 16·4 vs 37·7 ± 16·0 nm; P < 0·01) and lower BP (114/68 vs 121/73 mmHg; P < 0·05). CONCLUSIONS: Young adults born LGA presented higher BMI, WC and BP and appear to be at higher CMR risk than AGA subjects. The 737.738 IGF1 polymorphism appears to play a role on birth size and LGA-related metabolic outcomes. SN - 1365-2265 UR - https://www.unboundmedicine.com/medline/citation/21521322/Postnatal_growth_and_cardiometabolic_profile_in_young_adults_born_large_for_gestational_age_ L2 - https://doi.org/10.1111/j.1365-2265.2011.04054.x DB - PRIME DP - Unbound Medicine ER -