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Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis.
Clin Microbiol Infect. 2011 May; 17(5):780-4.CM

Abstract

Meningitis is associated with an imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMP (TIMPs). Serum and CSF were collected prospectively from all patients with meningitis between January 2008 and December 2008 to measure the concentrations of MMP/TIMP in those patients who underwent a lumbar puncture for a presumptive diagnosis of meningitis. A total of 199 patients were enrolled into the study. The concentrations of CSF MMP-9 and TIMP-1 were significantly higher in the meningitis group compared with the control group (p 0.032 and p <0.001, respectively). However, the CSF TIMP-4 levels were significantly lower in the meningitis groups compared with the control groups (p <0.001). Patients with bacterial meningitis had higher CSF MMP-9 and TIMP-1 levels than those who had aseptic meningitis and controls. Patients with various infectious meningitis etiologies tended to have higher CSF MMP-9 expression by gelatin zymography when compared with the controls. In conclusion, MMP/TIMP system dysregulation was found in patients with meningitis, and CSF MMP and TIMP might act as novel indicators in patients with meningitis.

Authors+Show Affiliations

Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21521415

Citation

Tsai, H-C, et al. "Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in the Serum and Cerebrospinal Fluid of Patients With Meningitis." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 17, no. 5, 2011, pp. 780-4.
Tsai HC, Shi MH, Lee SS, et al. Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis. Clin Microbiol Infect. 2011;17(5):780-4.
Tsai, H. C., Shi, M. H., Lee, S. S., Wann, S. R., Tai, M. H., & Chen, Y. S. (2011). Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 17(5), 780-4. https://doi.org/10.1111/j.1469-0691.2010.03393.x
Tsai HC, et al. Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in the Serum and Cerebrospinal Fluid of Patients With Meningitis. Clin Microbiol Infect. 2011;17(5):780-4. PubMed PMID: 21521415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with meningitis. AU - Tsai,H-C, AU - Shi,M-H, AU - Lee,S S-J, AU - Wann,S-R, AU - Tai,M-H, AU - Chen,Y-S, Y1 - 2010/12/03/ PY - 2011/4/28/entrez PY - 2011/4/28/pubmed PY - 2011/10/25/medline SP - 780 EP - 4 JF - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases JO - Clin Microbiol Infect VL - 17 IS - 5 N2 - Meningitis is associated with an imbalance between matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMP (TIMPs). Serum and CSF were collected prospectively from all patients with meningitis between January 2008 and December 2008 to measure the concentrations of MMP/TIMP in those patients who underwent a lumbar puncture for a presumptive diagnosis of meningitis. A total of 199 patients were enrolled into the study. The concentrations of CSF MMP-9 and TIMP-1 were significantly higher in the meningitis group compared with the control group (p 0.032 and p <0.001, respectively). However, the CSF TIMP-4 levels were significantly lower in the meningitis groups compared with the control groups (p <0.001). Patients with bacterial meningitis had higher CSF MMP-9 and TIMP-1 levels than those who had aseptic meningitis and controls. Patients with various infectious meningitis etiologies tended to have higher CSF MMP-9 expression by gelatin zymography when compared with the controls. In conclusion, MMP/TIMP system dysregulation was found in patients with meningitis, and CSF MMP and TIMP might act as novel indicators in patients with meningitis. SN - 1469-0691 UR - https://www.unboundmedicine.com/medline/citation/21521415/Expression_of_matrix_metalloproteinases_and_their_tissue_inhibitors_in_the_serum_and_cerebrospinal_fluid_of_patients_with_meningitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1198-743X(15)60276-2 DB - PRIME DP - Unbound Medicine ER -