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Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile.
Br J Nutr 2011; 106(2):282-91BJ

Abstract

There are concerns that weight-loss (WL) diets based on very low carbohydrate (LC) intake have a negative impact on antioxidant status and biomarkers of cardiovascular and metabolic health. Obese men (n 16) participated in a randomised, cross-over design diet trial, with food provided daily, at approximately 8.3 MJ/d (approximately 70 % of energy maintenance requirements). They were provided with two high-protein diets (30 % of energy), each for a 4-week period, involving a LC (4 % carbohydrate) and a moderate carbohydrate (MC, 35 % carbohydrate) content. Body weight was measured daily, and weekly blood samples were collected. On average, subjects lost 6.75 and 4.32 kg of weight on the LC and MC diets, respectively (P < 0.001, SED 0.350). Although the LC and MC diets were associated with a small reduction in plasma concentrations of retinol, vitamin E (α-tocopherol) and β-cryptoxanthin (P < 0.005), these were still above the values indicative of deficiency. Interestingly, plasma vitamin C concentrations increased on consumption of the LC diet (P < 0.05). Plasma markers of insulin resistance (P < 0.001), lipaemia and inflammation (P < 0.05, TNF-α and IL-10) improved similarly on both diets. There was no change in other cardiovascular markers with WL. The present data suggest that a LC WL diet does not impair plasma indices of cardiometabolic health, at least within 4 weeks, in otherwise healthy obese subjects. In general, improvements in metabolic health associated with WL were similar between the LC and MC diets. Antioxidant supplements may be warranted if LC WL diets are consumed for a prolonged period.

Authors+Show Affiliations

University of Aberdeen, Rowett Institute of Nutrition and Health, Aberdeen, Scotland, UK. alex.johnstone@abdn.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21521539

Citation

Johnstone, Alexandra M., et al. "Effects of a High-protein, Low-carbohydrate V. High-protein, Moderate-carbohydrate Weight-loss Diet On Antioxidant Status, Endothelial Markers and Plasma Indices of the Cardiometabolic Profile." The British Journal of Nutrition, vol. 106, no. 2, 2011, pp. 282-91.
Johnstone AM, Lobley GE, Horgan GW, et al. Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile. Br J Nutr. 2011;106(2):282-91.
Johnstone, A. M., Lobley, G. E., Horgan, G. W., Bremner, D. M., Fyfe, C. L., Morrice, P. C., & Duthie, G. G. (2011). Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile. The British Journal of Nutrition, 106(2), pp. 282-91. doi:10.1017/S0007114511000092.
Johnstone AM, et al. Effects of a High-protein, Low-carbohydrate V. High-protein, Moderate-carbohydrate Weight-loss Diet On Antioxidant Status, Endothelial Markers and Plasma Indices of the Cardiometabolic Profile. Br J Nutr. 2011;106(2):282-91. PubMed PMID: 21521539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile. AU - Johnstone,Alexandra M, AU - Lobley,Gerald E, AU - Horgan,Graham W, AU - Bremner,David M, AU - Fyfe,Claire L, AU - Morrice,Philip C, AU - Duthie,Garry G, PY - 2011/4/28/entrez PY - 2011/4/28/pubmed PY - 2012/8/7/medline SP - 282 EP - 91 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 106 IS - 2 N2 - There are concerns that weight-loss (WL) diets based on very low carbohydrate (LC) intake have a negative impact on antioxidant status and biomarkers of cardiovascular and metabolic health. Obese men (n 16) participated in a randomised, cross-over design diet trial, with food provided daily, at approximately 8.3 MJ/d (approximately 70 % of energy maintenance requirements). They were provided with two high-protein diets (30 % of energy), each for a 4-week period, involving a LC (4 % carbohydrate) and a moderate carbohydrate (MC, 35 % carbohydrate) content. Body weight was measured daily, and weekly blood samples were collected. On average, subjects lost 6.75 and 4.32 kg of weight on the LC and MC diets, respectively (P < 0.001, SED 0.350). Although the LC and MC diets were associated with a small reduction in plasma concentrations of retinol, vitamin E (α-tocopherol) and β-cryptoxanthin (P < 0.005), these were still above the values indicative of deficiency. Interestingly, plasma vitamin C concentrations increased on consumption of the LC diet (P < 0.05). Plasma markers of insulin resistance (P < 0.001), lipaemia and inflammation (P < 0.05, TNF-α and IL-10) improved similarly on both diets. There was no change in other cardiovascular markers with WL. The present data suggest that a LC WL diet does not impair plasma indices of cardiometabolic health, at least within 4 weeks, in otherwise healthy obese subjects. In general, improvements in metabolic health associated with WL were similar between the LC and MC diets. Antioxidant supplements may be warranted if LC WL diets are consumed for a prolonged period. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21521539/Effects_of_a_high_protein_low_carbohydrate_v__high_protein_moderate_carbohydrate_weight_loss_diet_on_antioxidant_status_endothelial_markers_and_plasma_indices_of_the_cardiometabolic_profile_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511000092/type/journal_article DB - PRIME DP - Unbound Medicine ER -