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Measurement of total serum cholesterol in the evaluation of suicidal risk.
J Affect Disord. 2011 Sep; 133(1-2):234-8.JA

Abstract

BACKGROUND

Many studies have demonstrated an association between suicidal behavior and low levels of total serum cholesterol. To our knowledge, this association has mainly been reported in men. This case-control study was undertaken to assess the association between serum cholesterol level and suicide attempts in both genders.

METHODS

A total of 3207 subjects was included, divided into three groups: 510 patients with a history of suicidal attempts, 275 patients with no history of suicidal attempts, and 2422 controls. Mean and quartile total cholesterol levels were compared between the three groups according to gender. ROC curves were drawn to determine the biologically relevant threshold.

RESULTS

After adjustment for age, cholesterol level was significantly lower (p<0.01) in suicide attempters than in non-attempters and controls for both genders. Male non-suicide attempters had similar cholesterol levels to controls (p=0.7), but the levels in female non-attempters were significantly higher (p=0.004). The proportion of suicide attempters in the lowest cholesterol level quartile (51.3% of men, 40.1% of women) was significantly higher than that in the highest quartile (8.1% of men, 12.4% of women). For triglyceride level, no difference was found between the three groups, suggesting that this association was not due to malnutrition linked to depression.

LIMITATIONS

The effect of acute or chronic administration of medications on serum cholesterol levels was not controlled. Psychiatric history in surgical controls was not recorded.

CONCLUSIONS

Total serum cholesterol levels measured at admission may be a useful biological marker of suicidal risk.

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Authors+Show Affiliations

Olié E
Université Montpellier 1, Montpellier, France.
Picot MC
No affiliation info available
Guillaume S
No affiliation info available
Abbar M
No affiliation info available
Courtet P
No affiliation info available

MeSH

AdultAgedCase-Control StudiesCholesterolCholesterol EstersCholesterol, LDLDepressionDepressive DisorderFemaleHumansMaleMental DisordersMiddle AgedRiskRisk FactorsSex FactorsSuicideSuicide, Attempted

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21521628

Citation

Olié, Emilie, et al. "Measurement of Total Serum Cholesterol in the Evaluation of Suicidal Risk." Journal of Affective Disorders, vol. 133, no. 1-2, 2011, pp. 234-8.
Olié E, Picot MC, Guillaume S, et al. Measurement of total serum cholesterol in the evaluation of suicidal risk. J Affect Disord. 2011;133(1-2):234-8.
Olié, E., Picot, M. C., Guillaume, S., Abbar, M., & Courtet, P. (2011). Measurement of total serum cholesterol in the evaluation of suicidal risk. Journal of Affective Disorders, 133(1-2), 234-8. https://doi.org/10.1016/j.jad.2011.03.028
Olié E, et al. Measurement of Total Serum Cholesterol in the Evaluation of Suicidal Risk. J Affect Disord. 2011;133(1-2):234-8. PubMed PMID: 21521628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of total serum cholesterol in the evaluation of suicidal risk. AU - Olié,Emilie, AU - Picot,Marie Christine, AU - Guillaume,Sébastien, AU - Abbar,Mocrane, AU - Courtet,Philippe, Y1 - 2011/04/27/ PY - 2010/07/08/received PY - 2011/02/18/revised PY - 2011/03/13/accepted PY - 2011/4/28/entrez PY - 2011/4/28/pubmed PY - 2011/11/8/medline SP - 234 EP - 8 JF - Journal of affective disorders JO - J Affect Disord VL - 133 IS - 1-2 N2 - BACKGROUND: Many studies have demonstrated an association between suicidal behavior and low levels of total serum cholesterol. To our knowledge, this association has mainly been reported in men. This case-control study was undertaken to assess the association between serum cholesterol level and suicide attempts in both genders. METHODS: A total of 3207 subjects was included, divided into three groups: 510 patients with a history of suicidal attempts, 275 patients with no history of suicidal attempts, and 2422 controls. Mean and quartile total cholesterol levels were compared between the three groups according to gender. ROC curves were drawn to determine the biologically relevant threshold. RESULTS: After adjustment for age, cholesterol level was significantly lower (p<0.01) in suicide attempters than in non-attempters and controls for both genders. Male non-suicide attempters had similar cholesterol levels to controls (p=0.7), but the levels in female non-attempters were significantly higher (p=0.004). The proportion of suicide attempters in the lowest cholesterol level quartile (51.3% of men, 40.1% of women) was significantly higher than that in the highest quartile (8.1% of men, 12.4% of women). For triglyceride level, no difference was found between the three groups, suggesting that this association was not due to malnutrition linked to depression. LIMITATIONS: The effect of acute or chronic administration of medications on serum cholesterol levels was not controlled. Psychiatric history in surgical controls was not recorded. CONCLUSIONS: Total serum cholesterol levels measured at admission may be a useful biological marker of suicidal risk. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/21521628/Measurement_of_total_serum_cholesterol_in_the_evaluation_of_suicidal_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(11)00111-X DB - PRIME DP - Unbound Medicine ER -