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Clinical effect of reduced-intensity conditioning regimen containing antithymocyte globulin for hematopoietic cell transplantation from unrelated-donors.
Am J Hematol. 2011 May; 86(5):399-405.AJ

Abstract

The impact of reduced-intensity conditioning (RIC) on the outcomes of hematopoietic cell transplantation (HCT) from unrelated -donors (UD) remains to be determined. We therefore assessed 128 patients, aged 16 to 66 years, with acute leukemia (n = 105) or myelodysplastic syndrome (n = 23) in a UD-HCT trial using RIC with busulfan, fludarabine, and antithymocyte globulin. Patients were transplanted with unmanipulated bone marrow (BM, n = 41) or mobilized peripheral blood mononuclear cells (M-PB, n = 87) and received cyclosporine and methotrexate for graft-versus-host disease (GVHD) prophylaxis. After a median follow-up of 26.7 months (range, 5.9-70.7 months) in surviving patients, 19 patients had died without progression/recurrence of underlying disease, giving a cumulative incidence of transplantation-related mortality (TRM) of 17% (95% confidence interval, 11%-27%; 1-year TRM, 14%). Graft failure (n = 7) and infections (n = 5) were the most common causes of TRM. Only three patients died due to GVHD (acute, one; chronic, two). Graft failure, which occurred in eight patients, showed a significant correlation with graft source (BM, 6/41 vs. M-PB, 2/87; P = 0.009). Donor-patient HLA-disparity did not correlate with GVHD, 1-year TRM, and graft failure. RIC containing antithymocyte globulin led to decreased GVHD-associated, as well as overall, TRM after UD-HCT.

Authors+Show Affiliations

Department of Internal Medicine, Hematology Section, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea. khlee2@amc.seoul.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

21523798

Citation

Lee, Kyoo-Hyung, et al. "Clinical Effect of Reduced-intensity Conditioning Regimen Containing Antithymocyte Globulin for Hematopoietic Cell Transplantation From Unrelated-donors." American Journal of Hematology, vol. 86, no. 5, 2011, pp. 399-405.
Lee KH, Choi SJ, Lee JH, et al. Clinical effect of reduced-intensity conditioning regimen containing antithymocyte globulin for hematopoietic cell transplantation from unrelated-donors. Am J Hematol. 2011;86(5):399-405.
Lee, K. H., Choi, S. J., Lee, J. H., Lee, J. H., Kim, D. Y., Seol, M., Lee, Y. S., Kang, Y. A., Jeon, M., Yun, S. C., Joo, Y. D., Lee, W. S., Kang, M. J., Kim, H., Park, J. H., Bae, S. H., Ryoo, H. M., Kim, M. K., & Hyun, M. S. (2011). Clinical effect of reduced-intensity conditioning regimen containing antithymocyte globulin for hematopoietic cell transplantation from unrelated-donors. American Journal of Hematology, 86(5), 399-405. https://doi.org/10.1002/ajh.21989
Lee KH, et al. Clinical Effect of Reduced-intensity Conditioning Regimen Containing Antithymocyte Globulin for Hematopoietic Cell Transplantation From Unrelated-donors. Am J Hematol. 2011;86(5):399-405. PubMed PMID: 21523798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical effect of reduced-intensity conditioning regimen containing antithymocyte globulin for hematopoietic cell transplantation from unrelated-donors. AU - Lee,Kyoo-Hyung, AU - Choi,Seong-Jun, AU - Lee,Je-Hwan, AU - Lee,Jung-Hee, AU - Kim,Dae-Young, AU - Seol,Miee, AU - Lee,Young-Shin, AU - Kang,Young-Ah, AU - Jeon,Mijin, AU - Yun,Sung-Cheol, AU - Joo,Young-Don, AU - Lee,Won-Sik, AU - Kang,Myoung-Joo, AU - Kim,Hawk, AU - Park,Jae-Hoo, AU - Bae,Sung-Hwa, AU - Ryoo,Hun-Mo, AU - Kim,Min-Kyoung, AU - Hyun,Myung-Soo, PY - 2011/4/28/entrez PY - 2011/4/28/pubmed PY - 2011/7/14/medline SP - 399 EP - 405 JF - American journal of hematology JO - Am J Hematol VL - 86 IS - 5 N2 - The impact of reduced-intensity conditioning (RIC) on the outcomes of hematopoietic cell transplantation (HCT) from unrelated -donors (UD) remains to be determined. We therefore assessed 128 patients, aged 16 to 66 years, with acute leukemia (n = 105) or myelodysplastic syndrome (n = 23) in a UD-HCT trial using RIC with busulfan, fludarabine, and antithymocyte globulin. Patients were transplanted with unmanipulated bone marrow (BM, n = 41) or mobilized peripheral blood mononuclear cells (M-PB, n = 87) and received cyclosporine and methotrexate for graft-versus-host disease (GVHD) prophylaxis. After a median follow-up of 26.7 months (range, 5.9-70.7 months) in surviving patients, 19 patients had died without progression/recurrence of underlying disease, giving a cumulative incidence of transplantation-related mortality (TRM) of 17% (95% confidence interval, 11%-27%; 1-year TRM, 14%). Graft failure (n = 7) and infections (n = 5) were the most common causes of TRM. Only three patients died due to GVHD (acute, one; chronic, two). Graft failure, which occurred in eight patients, showed a significant correlation with graft source (BM, 6/41 vs. M-PB, 2/87; P = 0.009). Donor-patient HLA-disparity did not correlate with GVHD, 1-year TRM, and graft failure. RIC containing antithymocyte globulin led to decreased GVHD-associated, as well as overall, TRM after UD-HCT. SN - 1096-8652 UR - https://www.unboundmedicine.com/medline/citation/21523798/Clinical_effect_of_reduced_intensity_conditioning_regimen_containing_antithymocyte_globulin_for_hematopoietic_cell_transplantation_from_unrelated_donors_ L2 - https://doi.org/10.1002/ajh.21989 DB - PRIME DP - Unbound Medicine ER -