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Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men.
J Nutr. 2011 Jun; 141(6):1188-94.JN

Abstract

On the basis of previous results from this laboratory, this study tested the hypothesis that ground beef high in MUFA and low in SFA would increase the HDL-cholesterol (HDL-C) concentration and LDL particle diameter. In a crossover dietary intervention, 27 free-living normocholesterolemic men completed treatments in which five 114-g ground beef patties/wk were consumed for 5 wk with an intervening 4-wk washout period. Patties contained 24% total fat with a MUFA:SFA ratio of either 0.71 (low MUFA, from pasture-fed cattle) or 1.10 (high MUFA, from grain-fed cattle). High-MUFA ground beef provided 3.21 g more 18:1(n-9), 1.26 g less 18:0, 0.89 g less 16:0, and 0.36 g less 18:1(trans) fatty acids per patty than did the low-MUFA ground beef. Both ground beef interventions decreased plasma insulin and HDL(2) and HDL(3) particle diameters and increased plasma 18:0 and 20:4(n-6) (all P ≤ 0.05) relative to baseline values. Only the high-MUFA ground beef intervention increased the HDL-C concentration from baseline (P = 0.02). The plasma TG concentration was positively correlated with the plasma insulin concentration (r = 0.40; P < 0.001) and negatively correlated with HDL-C (r = -0.47; P < 0.001) and plasma 18:0 (r = -0.24; P < 0.01). Plasma insulin and HDL diameters were not correlated (r = 0.01; P > 0.50), indicating that reductions in these measures were not coordinately regulated. The data indicate that dietary beef interventions have effects on risk factors for cardiovascular disease that are independent (insulin, HDL diameters) and dependent (HDL-C) on beef fatty acid composition.

Authors+Show Affiliations

Department of Animal Science, and Texas A&M University, College Station, TX 77843, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21525253

Citation

Gilmore, L Anne, et al. "Consumption of High-oleic Acid Ground Beef Increases HDL-cholesterol Concentration but Both High- and Low-oleic Acid Ground Beef Decrease HDL Particle Diameter in Normocholesterolemic Men." The Journal of Nutrition, vol. 141, no. 6, 2011, pp. 1188-94.
Gilmore LA, Walzem RL, Crouse SF, et al. Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men. J Nutr. 2011;141(6):1188-94.
Gilmore, L. A., Walzem, R. L., Crouse, S. F., Smith, D. R., Adams, T. H., Vaidyanathan, V., Cao, X., & Smith, S. B. (2011). Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men. The Journal of Nutrition, 141(6), 1188-94. https://doi.org/10.3945/jn.110.136085
Gilmore LA, et al. Consumption of High-oleic Acid Ground Beef Increases HDL-cholesterol Concentration but Both High- and Low-oleic Acid Ground Beef Decrease HDL Particle Diameter in Normocholesterolemic Men. J Nutr. 2011;141(6):1188-94. PubMed PMID: 21525253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of high-oleic acid ground beef increases HDL-cholesterol concentration but both high- and low-oleic acid ground beef decrease HDL particle diameter in normocholesterolemic men. AU - Gilmore,L Anne, AU - Walzem,Rosemary L, AU - Crouse,Stephen F, AU - Smith,Dana R, AU - Adams,Thaddeus H, AU - Vaidyanathan,Vidya, AU - Cao,Xiaojuan, AU - Smith,Stephen B, Y1 - 2011/04/27/ PY - 2011/4/29/entrez PY - 2011/4/29/pubmed PY - 2011/8/10/medline SP - 1188 EP - 94 JF - The Journal of nutrition JO - J Nutr VL - 141 IS - 6 N2 - On the basis of previous results from this laboratory, this study tested the hypothesis that ground beef high in MUFA and low in SFA would increase the HDL-cholesterol (HDL-C) concentration and LDL particle diameter. In a crossover dietary intervention, 27 free-living normocholesterolemic men completed treatments in which five 114-g ground beef patties/wk were consumed for 5 wk with an intervening 4-wk washout period. Patties contained 24% total fat with a MUFA:SFA ratio of either 0.71 (low MUFA, from pasture-fed cattle) or 1.10 (high MUFA, from grain-fed cattle). High-MUFA ground beef provided 3.21 g more 18:1(n-9), 1.26 g less 18:0, 0.89 g less 16:0, and 0.36 g less 18:1(trans) fatty acids per patty than did the low-MUFA ground beef. Both ground beef interventions decreased plasma insulin and HDL(2) and HDL(3) particle diameters and increased plasma 18:0 and 20:4(n-6) (all P ≤ 0.05) relative to baseline values. Only the high-MUFA ground beef intervention increased the HDL-C concentration from baseline (P = 0.02). The plasma TG concentration was positively correlated with the plasma insulin concentration (r = 0.40; P < 0.001) and negatively correlated with HDL-C (r = -0.47; P < 0.001) and plasma 18:0 (r = -0.24; P < 0.01). Plasma insulin and HDL diameters were not correlated (r = 0.01; P > 0.50), indicating that reductions in these measures were not coordinately regulated. The data indicate that dietary beef interventions have effects on risk factors for cardiovascular disease that are independent (insulin, HDL diameters) and dependent (HDL-C) on beef fatty acid composition. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/21525253/Consumption_of_high_oleic_acid_ground_beef_increases_HDL_cholesterol_concentration_but_both_high__and_low_oleic_acid_ground_beef_decrease_HDL_particle_diameter_in_normocholesterolemic_men_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.3945/jn.110.136085 DB - PRIME DP - Unbound Medicine ER -