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Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Côte d'Ivoire.
Malar J. 2011 Apr 29; 10:105.MJ

Abstract

BACKGROUND

The World Health Organization (WHO) recommends using insecticide-treated mosquito nets (ITNs) and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) to prevent malaria in sub-Saharan Africa. Data on IPT-SP coverage and factors associated with placental malaria parasitaemia and low birth weight (LBW) are scarce in Côte d'Ivoire.

METHODS

A multicentre, cross-sectional survey was conducted in Côte d'Ivoire from March to September 2008 at six urban and semi-urban antenatal clinics. Standardized forms were used to collect the demographic information and medical histories of women and their offspring. IPT-SP coverage (≥2 doses) as well as placental and congenital malaria prevalence parasitaemia were estimated. Regression logistics were used to study factors associated with placental malaria and LBW (birth weight of alive babies < 2,500 grams).

RESULTS

Overall, 2,044 women with a median age of 24 years were included in this study. Among them 1017 (49.8%) received ≥2 doses of IPT-SP and 694 (34.0%) received one dose. A total of 99 mothers (4.8%) had placental malaria, and of them, four cases of congenital malaria were diagnosed. Factors that protected from maternal placental malaria parasitaemia were the use of one dose (adjusted odds ratio (aOR), 0.32; 95%CI: 0.19-0.55) or ≥2 doses IPT-SP (aOR: 0.18; 95%CI: 0.10-0.32); the use of ITNs (aOR: 0.47; 95%CI: 0.27-0.82). LBW was associated with primigravidity and placental malaria parasitaemia.

CONCLUSION

IPT-SP decreases the rate of placental malaria parasitaemia and has a strong dose effect. Despite relatively successful IPT-SP coverage in Côte d'Ivoire, substantial commitments from national authorities are urgently required for such public health campaigns. Strategies, such as providing IPT-SP free of charge and directly observing treatment, should be implemented to increase the use of IPT-SP as well as other prophylactic methods.

Authors+Show Affiliations

Programme PAC-CI, Abidjan, Côte d'Ivoire. didier.ekouevi@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21529344

Citation

Vanga-Bosson, Henriette A., et al. "Coverage of Intermittent Prevention Treatment With Sulphadoxine-pyrimethamine Among Pregnant Women and Congenital Malaria in Côte D'Ivoire." Malaria Journal, vol. 10, 2011, p. 105.
Vanga-Bosson HA, Coffie PA, Kanhon S, et al. Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Côte d'Ivoire. Malar J. 2011;10:105.
Vanga-Bosson, H. A., Coffie, P. A., Kanhon, S., Sloan, C., Kouakou, F., Eholie, S. P., Kone, M., Dabis, F., Menan, H., & Ekouevi, D. K. (2011). Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Côte d'Ivoire. Malaria Journal, 10, 105. https://doi.org/10.1186/1475-2875-10-105
Vanga-Bosson HA, et al. Coverage of Intermittent Prevention Treatment With Sulphadoxine-pyrimethamine Among Pregnant Women and Congenital Malaria in Côte D'Ivoire. Malar J. 2011 Apr 29;10:105. PubMed PMID: 21529344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coverage of intermittent prevention treatment with sulphadoxine-pyrimethamine among pregnant women and congenital malaria in Côte d'Ivoire. AU - Vanga-Bosson,Henriette A, AU - Coffie,Patrick A, AU - Kanhon,Serge, AU - Sloan,Caroline, AU - Kouakou,Firmin, AU - Eholie,Serge P, AU - Kone,Moussa, AU - Dabis,François, AU - Menan,Hervé, AU - Ekouevi,Didier K, Y1 - 2011/04/29/ PY - 2010/12/10/received PY - 2011/04/29/accepted PY - 2011/5/3/entrez PY - 2011/5/3/pubmed PY - 2011/9/8/medline SP - 105 EP - 105 JF - Malaria journal JO - Malar J VL - 10 N2 - BACKGROUND: The World Health Organization (WHO) recommends using insecticide-treated mosquito nets (ITNs) and intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) to prevent malaria in sub-Saharan Africa. Data on IPT-SP coverage and factors associated with placental malaria parasitaemia and low birth weight (LBW) are scarce in Côte d'Ivoire. METHODS: A multicentre, cross-sectional survey was conducted in Côte d'Ivoire from March to September 2008 at six urban and semi-urban antenatal clinics. Standardized forms were used to collect the demographic information and medical histories of women and their offspring. IPT-SP coverage (≥2 doses) as well as placental and congenital malaria prevalence parasitaemia were estimated. Regression logistics were used to study factors associated with placental malaria and LBW (birth weight of alive babies < 2,500 grams). RESULTS: Overall, 2,044 women with a median age of 24 years were included in this study. Among them 1017 (49.8%) received ≥2 doses of IPT-SP and 694 (34.0%) received one dose. A total of 99 mothers (4.8%) had placental malaria, and of them, four cases of congenital malaria were diagnosed. Factors that protected from maternal placental malaria parasitaemia were the use of one dose (adjusted odds ratio (aOR), 0.32; 95%CI: 0.19-0.55) or ≥2 doses IPT-SP (aOR: 0.18; 95%CI: 0.10-0.32); the use of ITNs (aOR: 0.47; 95%CI: 0.27-0.82). LBW was associated with primigravidity and placental malaria parasitaemia. CONCLUSION: IPT-SP decreases the rate of placental malaria parasitaemia and has a strong dose effect. Despite relatively successful IPT-SP coverage in Côte d'Ivoire, substantial commitments from national authorities are urgently required for such public health campaigns. Strategies, such as providing IPT-SP free of charge and directly observing treatment, should be implemented to increase the use of IPT-SP as well as other prophylactic methods. SN - 1475-2875 UR - https://www.unboundmedicine.com/medline/citation/21529344/Coverage_of_intermittent_prevention_treatment_with_sulphadoxine_pyrimethamine_among_pregnant_women_and_congenital_malaria_in_Côte_d'Ivoire_ L2 - https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-10-105 DB - PRIME DP - Unbound Medicine ER -