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Steroid up-regulation of FKBP51 and its role in hormone signaling.
Curr Opin Pharmacol. 2011 Aug; 11(4):326-31.CO

Abstract

FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an important determinant of the responses to steroids, especially to glucocorticoids in stress and mood disorders and androgens in prostate cancer, raising medical and pharmacological interests in the protein and its gene. Recent studies have revealed the molecular mechanisms by which the androgens and the glucocorticoids via their nuclear receptors elicit the robust up-regulation of the FKBP51 gene. Several polymorphisms in the FKBP51 gene have been associated with the mood disorders and differences in glucocorticoid sensitivity. The polymorphisms may contribute to the steroid up-regulation of the FKBP51 and thus influence the regulatory loops in steroid signaling.

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Authors+Show Affiliations

Jääskeläinen T
Institute of Biomedicine/Medical Biochemistry, University of Eastern Finland, Kuopio, FI-70211 Kuopio, Finland.
Makkonen H
No affiliation info available
Palvimo JJ
No affiliation info available

MeSH

AndrogensAnimalsGlucocorticoidsHumansPolymorphism, GeneticReceptors, SteroidSignal TransductionSteroidsTacrolimus Binding ProteinsUp-Regulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21531172

Citation

Jääskeläinen, Tiina, et al. "Steroid Up-regulation of FKBP51 and Its Role in Hormone Signaling." Current Opinion in Pharmacology, vol. 11, no. 4, 2011, pp. 326-31.
Jääskeläinen T, Makkonen H, Palvimo JJ. Steroid up-regulation of FKBP51 and its role in hormone signaling. Curr Opin Pharmacol. 2011;11(4):326-31.
Jääskeläinen, T., Makkonen, H., & Palvimo, J. J. (2011). Steroid up-regulation of FKBP51 and its role in hormone signaling. Current Opinion in Pharmacology, 11(4), 326-31. https://doi.org/10.1016/j.coph.2011.04.006
Jääskeläinen T, Makkonen H, Palvimo JJ. Steroid Up-regulation of FKBP51 and Its Role in Hormone Signaling. Curr Opin Pharmacol. 2011;11(4):326-31. PubMed PMID: 21531172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroid up-regulation of FKBP51 and its role in hormone signaling. AU - Jääskeläinen,Tiina, AU - Makkonen,Harri, AU - Palvimo,Jorma J, Y1 - 2011/04/29/ PY - 2011/04/04/received PY - 2011/04/11/accepted PY - 2011/5/3/entrez PY - 2011/5/3/pubmed PY - 2011/12/14/medline SP - 326 EP - 31 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 11 IS - 4 N2 - FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen, glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an important determinant of the responses to steroids, especially to glucocorticoids in stress and mood disorders and androgens in prostate cancer, raising medical and pharmacological interests in the protein and its gene. Recent studies have revealed the molecular mechanisms by which the androgens and the glucocorticoids via their nuclear receptors elicit the robust up-regulation of the FKBP51 gene. Several polymorphisms in the FKBP51 gene have been associated with the mood disorders and differences in glucocorticoid sensitivity. The polymorphisms may contribute to the steroid up-regulation of the FKBP51 and thus influence the regulatory loops in steroid signaling. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/21531172/Steroid_up_regulation_of_FKBP51_and_its_role_in_hormone_signaling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4892(11)00058-0 DB - PRIME DP - Unbound Medicine ER -