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The aging hippocampus: interactions between exercise, depression, and BDNF.

Abstract

Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy.

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  • Authors+Show Affiliations

    ,

    Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA. kiericks@pitt.edu

    ,

    Source

    MeSH

    Aging
    Animals
    Atrophy
    Brain-Derived Neurotrophic Factor
    Depression
    Exercise
    Genotype
    Hippocampus
    Humans
    Memory
    Methionine
    Mice
    Polymorphism, Genetic
    Polymorphism, Single Nucleotide
    Rats
    Valine

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    21531985

    Citation

    Erickson, Kirk I., et al. "The Aging Hippocampus: Interactions Between Exercise, Depression, and BDNF." The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, vol. 18, no. 1, 2012, pp. 82-97.
    Erickson KI, Miller DL, Roecklein KA. The aging hippocampus: interactions between exercise, depression, and BDNF. Neuroscientist. 2012;18(1):82-97.
    Erickson, K. I., Miller, D. L., & Roecklein, K. A. (2012). The aging hippocampus: interactions between exercise, depression, and BDNF. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry, 18(1), pp. 82-97. doi:10.1177/1073858410397054.
    Erickson KI, Miller DL, Roecklein KA. The Aging Hippocampus: Interactions Between Exercise, Depression, and BDNF. Neuroscientist. 2012;18(1):82-97. PubMed PMID: 21531985.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The aging hippocampus: interactions between exercise, depression, and BDNF. AU - Erickson,Kirk I, AU - Miller,Destiny L, AU - Roecklein,Kathryn A, Y1 - 2011/04/29/ PY - 2011/5/3/entrez PY - 2011/5/3/pubmed PY - 2012/5/19/medline SP - 82 EP - 97 JF - The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry JO - Neuroscientist VL - 18 IS - 1 N2 - Late adulthood is associated with increased hippocampal atrophy and dysfunction. Although there are multiple paths by which hippocampal deterioration occurs in late life, the authors discuss the evidence that a single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and age-related changes in BDNF protein or receptor expression contribute to hippocampal atrophy. The authors conclude that few studies have tested whether BDNF mediates age-related hippocampal atrophy and memory impairment. However, there is strong evidence that decreased BDNF is associated with age-related hippocampal dysfunction, memory impairment, and increased risk for depression, whereas increasing BDNF by aerobic exercise appears to ameliorate hippocampal atrophy, improve memory function, and reduce depression. Importantly, the most consistent associations between BDNF and hippocampal dysfunction have emerged from research on BDNF protein expression in rodents and serum and plasma concentrations of BDNF in humans. Current research suggests that the BDNF val66met polymorphism may be only weakly associated with hippocampal atrophy in late adulthood. These conclusions are interpreted in relation to age-related memory impairment and preventions for hippocampal atrophy. SN - 1089-4098 UR - https://www.unboundmedicine.com/medline/citation/21531985/The_aging_hippocampus:_interactions_between_exercise_depression_and_BDNF_ L2 - http://journals.sagepub.com/doi/full/10.1177/1073858410397054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -