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Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study.
Med Biol Eng Comput. 2011 May; 49(5):555-65.MB

Abstract

To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the frequency domain was performed in the low frequency bands with dynamic imaging of coherent sources. The results were projected on a three-dimensional surface rendering of the brain using a semi-realistic head model and MRI images obtained for each of the five patients studied. An increase in clustering and a decrease in path length preceding SWD onset and a rhythmic pattern of increasing and decreasing connectivity were seen during SWDs. Beamforming showed a consistent appearance of a low frequency frontal cortical source prior to the first generalized spikes. This source was preceded by a low frequency occipital source. The changes in the connectivity networks with the onset of SWDs suggest a pathologically predisposed state towards synchronous seizure networks with increasing connectivity from interictal to preictal and ictal state, while the occipital and frontal low frequency early preictal sources demonstrate that SWDs are not suddenly arising but gradually build up in a dynamic network.

Authors+Show Affiliations

Donders Centre for Cognition, Institute for Brain Cognition and Behaviour, Radboud University Nijmegen, Montessorilaan 3, Nijmegen, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21533620

Citation

Gupta, Disha, et al. "Space-time Network Connectivity and Cortical Activations Preceding Spike Wave Discharges in Human Absence Epilepsy: a MEG Study." Medical & Biological Engineering & Computing, vol. 49, no. 5, 2011, pp. 555-65.
Gupta D, Ossenblok P, van Luijtelaar G. Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study. Med Biol Eng Comput. 2011;49(5):555-65.
Gupta, D., Ossenblok, P., & van Luijtelaar, G. (2011). Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study. Medical & Biological Engineering & Computing, 49(5), 555-65. https://doi.org/10.1007/s11517-011-0778-3
Gupta D, Ossenblok P, van Luijtelaar G. Space-time Network Connectivity and Cortical Activations Preceding Spike Wave Discharges in Human Absence Epilepsy: a MEG Study. Med Biol Eng Comput. 2011;49(5):555-65. PubMed PMID: 21533620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Space-time network connectivity and cortical activations preceding spike wave discharges in human absence epilepsy: a MEG study. AU - Gupta,Disha, AU - Ossenblok,Pauly, AU - van Luijtelaar,Gilles, Y1 - 2011/04/30/ PY - 2010/11/01/received PY - 2011/04/07/accepted PY - 2011/5/3/entrez PY - 2011/5/3/pubmed PY - 2011/12/13/medline SP - 555 EP - 65 JF - Medical & biological engineering & computing JO - Med Biol Eng Comput VL - 49 IS - 5 N2 - To describe the spatial and temporal profiles of connectivity networks and sources preceding generalized spike-and-wave discharges (SWDs) in human absence epilepsy. Nonlinear associations of MEG signals and cluster indices obtained within the framework of graph theory were determined, while source localization in the frequency domain was performed in the low frequency bands with dynamic imaging of coherent sources. The results were projected on a three-dimensional surface rendering of the brain using a semi-realistic head model and MRI images obtained for each of the five patients studied. An increase in clustering and a decrease in path length preceding SWD onset and a rhythmic pattern of increasing and decreasing connectivity were seen during SWDs. Beamforming showed a consistent appearance of a low frequency frontal cortical source prior to the first generalized spikes. This source was preceded by a low frequency occipital source. The changes in the connectivity networks with the onset of SWDs suggest a pathologically predisposed state towards synchronous seizure networks with increasing connectivity from interictal to preictal and ictal state, while the occipital and frontal low frequency early preictal sources demonstrate that SWDs are not suddenly arising but gradually build up in a dynamic network. SN - 1741-0444 UR - https://www.unboundmedicine.com/medline/citation/21533620/Space_time_network_connectivity_and_cortical_activations_preceding_spike_wave_discharges_in_human_absence_epilepsy:_a_MEG_study_ L2 - https://dx.doi.org/10.1007/s11517-011-0778-3 DB - PRIME DP - Unbound Medicine ER -