Tags

Type your tag names separated by a space and hit enter

A single nasal dose of CCL20 chemokine induces dendritic cell recruitment and enhances nontypable Haemophilus influenzae-specific immune responses in the nasal mucosa.
Acta Otolaryngol. 2011 Sep; 131(9):989-96.AO

Abstract

CONCLUSION

The results of the present study indicate the potential of CCL20 as an effective mucosal adjuvant and suggest that nasal vaccination with P6 in combination with nasal CCL20 might be an effective regimen for the induction of nontypable Haemophilus influenzae (NTHi)-specific protective immunity.

OBJECTIVES

Nasal vaccination is an effective therapeutic regimen for preventing upper respiratory infections. In the development of nasal vaccine, an appropriate adjuvant is required. In the present study we examined the efficacy of CCL20 as a mucosal adjuvant.

METHODS

CCL20 was administered intranasally to mice, which were then immunized intranasally with P6 protein of NTHi, and P6-specific immune responses were examined. In addition, NTHi challenges were performed and the level of NTHi was quantified in nasal washes.

RESULTS

Nasal application of CCL20 induced an increase in the number of dendritic cells in nasal-associated lymphoid tissue. P6-specific nasal wash immunoglobulin (Ig)A and serum IgG titers were elevated significantly after nasal immunization. Enhanced NTHi clearance from the nasopharynx was also observed.

Authors+Show Affiliations

Department of Otolaryngology, Oita University Faculty of Medicine, Yufu, Japan. satoruk@oita-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21534717

Citation

Kodama, Satoru, et al. "A Single Nasal Dose of CCL20 Chemokine Induces Dendritic Cell Recruitment and Enhances Nontypable Haemophilus Influenzae-specific Immune Responses in the Nasal Mucosa." Acta Oto-laryngologica, vol. 131, no. 9, 2011, pp. 989-96.
Kodama S, Abe N, Hirano T, et al. A single nasal dose of CCL20 chemokine induces dendritic cell recruitment and enhances nontypable Haemophilus influenzae-specific immune responses in the nasal mucosa. Acta Otolaryngol. 2011;131(9):989-96.
Kodama, S., Abe, N., Hirano, T., & Suzuki, M. (2011). A single nasal dose of CCL20 chemokine induces dendritic cell recruitment and enhances nontypable Haemophilus influenzae-specific immune responses in the nasal mucosa. Acta Oto-laryngologica, 131(9), 989-96. https://doi.org/10.3109/00016489.2011.576429
Kodama S, et al. A Single Nasal Dose of CCL20 Chemokine Induces Dendritic Cell Recruitment and Enhances Nontypable Haemophilus Influenzae-specific Immune Responses in the Nasal Mucosa. Acta Otolaryngol. 2011;131(9):989-96. PubMed PMID: 21534717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A single nasal dose of CCL20 chemokine induces dendritic cell recruitment and enhances nontypable Haemophilus influenzae-specific immune responses in the nasal mucosa. AU - Kodama,Satoru, AU - Abe,Nobuyuki, AU - Hirano,Takashi, AU - Suzuki,Masashi, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/1/28/medline SP - 989 EP - 96 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 131 IS - 9 N2 - CONCLUSION: The results of the present study indicate the potential of CCL20 as an effective mucosal adjuvant and suggest that nasal vaccination with P6 in combination with nasal CCL20 might be an effective regimen for the induction of nontypable Haemophilus influenzae (NTHi)-specific protective immunity. OBJECTIVES: Nasal vaccination is an effective therapeutic regimen for preventing upper respiratory infections. In the development of nasal vaccine, an appropriate adjuvant is required. In the present study we examined the efficacy of CCL20 as a mucosal adjuvant. METHODS: CCL20 was administered intranasally to mice, which were then immunized intranasally with P6 protein of NTHi, and P6-specific immune responses were examined. In addition, NTHi challenges were performed and the level of NTHi was quantified in nasal washes. RESULTS: Nasal application of CCL20 induced an increase in the number of dendritic cells in nasal-associated lymphoid tissue. P6-specific nasal wash immunoglobulin (Ig)A and serum IgG titers were elevated significantly after nasal immunization. Enhanced NTHi clearance from the nasopharynx was also observed. SN - 1651-2251 UR - https://www.unboundmedicine.com/medline/citation/21534717/A_single_nasal_dose_of_CCL20_chemokine_induces_dendritic_cell_recruitment_and_enhances_nontypable_Haemophilus_influenzae_specific_immune_responses_in_the_nasal_mucosa_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489.2011.576429 DB - PRIME DP - Unbound Medicine ER -