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Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study.
J Intern Med 2012; 271(1):43-50JI

Abstract

AIMS

Oxidative stress plays a critical role in the initiation and progression of atherosclerosis. Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether an increased serum concentration of MPO is associated with an increased risk of incident coronary heart disease (CHD).

METHODS

We conducted a population-based case-cohort study in middle-aged, healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of MPO were measured in 333 subjects with (cases) and 1727 without (noncases) incident CHD. Mean follow-up time was 10.8 ± 4.6 years.

RESULTS

Baseline concentrations of MPO were higher in cases compared with noncases (P ≤ 0.001 in men; P=0.131 in women). After adjustment for major cardiovascular risk factors, the hazard ratio (HR) with 95% confidence interval (CI) comparing the top with the two lower tertiles was 1.70 (95% CI, 1.25-2.30). After additional adjustment for markers of inflammation and endothelial dysfunction, the association was attenuated (HR 1.50; 95% CI, 1.08-2.09). There were no significant interactions of MPO with sex or increased weight on CHD risk.

CONCLUSIONS

Elevated concentrations of the oxidative stress marker MPO were independently associated with increased risk of incident CHD. This finding deserves detailed evaluation in further studies.

Authors+Show Affiliations

Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21535251

Citation

Karakas, M, et al. "Myeloperoxidase Is Associated With Incident Coronary Heart Disease Independently of Traditional Risk Factors: Results From the MONICA/KORA Augsburg Study." Journal of Internal Medicine, vol. 271, no. 1, 2012, pp. 43-50.
Karakas M, Koenig W, Zierer A, et al. Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study. J Intern Med. 2012;271(1):43-50.
Karakas, M., Koenig, W., Zierer, A., Herder, C., Rottbauer, W., Baumert, J., ... Thorand, B. (2012). Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study. Journal of Internal Medicine, 271(1), pp. 43-50. doi:10.1111/j.1365-2796.2011.02397.x.
Karakas M, et al. Myeloperoxidase Is Associated With Incident Coronary Heart Disease Independently of Traditional Risk Factors: Results From the MONICA/KORA Augsburg Study. J Intern Med. 2012;271(1):43-50. PubMed PMID: 21535251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study. AU - Karakas,M, AU - Koenig,W, AU - Zierer,A, AU - Herder,C, AU - Rottbauer,W, AU - Baumert,J, AU - Meisinger,C, AU - Thorand,B, Y1 - 2011/05/30/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/2/22/medline SP - 43 EP - 50 JF - Journal of internal medicine JO - J. Intern. Med. VL - 271 IS - 1 N2 - AIMS: Oxidative stress plays a critical role in the initiation and progression of atherosclerosis. Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether an increased serum concentration of MPO is associated with an increased risk of incident coronary heart disease (CHD). METHODS: We conducted a population-based case-cohort study in middle-aged, healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of MPO were measured in 333 subjects with (cases) and 1727 without (noncases) incident CHD. Mean follow-up time was 10.8 ± 4.6 years. RESULTS: Baseline concentrations of MPO were higher in cases compared with noncases (P ≤ 0.001 in men; P=0.131 in women). After adjustment for major cardiovascular risk factors, the hazard ratio (HR) with 95% confidence interval (CI) comparing the top with the two lower tertiles was 1.70 (95% CI, 1.25-2.30). After additional adjustment for markers of inflammation and endothelial dysfunction, the association was attenuated (HR 1.50; 95% CI, 1.08-2.09). There were no significant interactions of MPO with sex or increased weight on CHD risk. CONCLUSIONS: Elevated concentrations of the oxidative stress marker MPO were independently associated with increased risk of incident CHD. This finding deserves detailed evaluation in further studies. SN - 1365-2796 UR - https://www.unboundmedicine.com/medline/citation/21535251/full_citation L2 - https://doi.org/10.1111/j.1365-2796.2011.02397.x DB - PRIME DP - Unbound Medicine ER -