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Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities.
J Food Sci. 2011 Apr; 76(3):C512-8.JF

Abstract

GC-FID and GC-MS analysis of essential oil from oregano leaves (Origanum compactum) resulted in the identification of 46 compounds, representing more than 98% of the total composition. Carvacrol was the predominant compound (36.46%), followed by thymol (29.74%) and p-cymene (24.31%). Serial extractions with petroleum ether, ethyl acetate, ethanol, and water were performed on aerials parts of Origanum compactum. In these extracts, different chemical families were characterized: polyphenols (gallic acid equivalent 21.2 to 858.3 g/kg), tannins (catechin equivalent 12.4 to 510.3 g/kg), anthocyanins (cyanidin equivalent 0.38 to 5.63 mg/kg), and flavonoids (quercetin equivalent 14.5 to 54.7 g/kg). The samples (essential oil and extracts) were subjected to a screening for antioxidant (DPPH and ABTS assays) and antimalarial activities and against human breast cancer cells. The essential oil showed a higher antioxidant activity with an IC50=2±0.1 mg/L. Among the extracts, the aqueous extract had the highest antioxidant activity with an IC50=4.8±0.2 mg/L (DPPH assay). Concerning antimalarial activity, Origanum compactum essential oil and ethyl acetate extract showed the best results with an IC50 of 34 and 33 mg/mL, respectively. In addition, ethyl acetate extract (30 mg/L) and ethanol extract (56 mg/L) showed activity against human breast cancer cells (MCF7). The oregano essential oil was considered to be nontoxic.

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Publisher Full Text (DOI)

Authors+Show Affiliations

El Babili F
Faculté des Sciences Pharmaceutiques de Toulouse, Laboratoire de Botanique-Mycologie, 35 ch. des Maraîchers, F- 31062 Toulouse, France. elbabili@cict.fr
Bouajila J
No affiliation info available
Souchard JP
No affiliation info available
Bertrand C
No affiliation info available
Bellvert F
No affiliation info available
Fouraste I
No affiliation info available
Moulis C
No affiliation info available
Valentin A
No affiliation info available

MeSH

AnthocyaninsAntimalarialsAntineoplastic Agents, PhytogenicAntioxidantsBreast NeoplasmsCell Line, TumorDrug DiscoveryFemaleFlame IonizationFlavonoidsGas Chromatography-Mass SpectrometryHumansInhibitory Concentration 50Medicine, African TraditionalMoroccoOils, VolatileOriganumPhenolsPlant Components, AerialPlant ExtractsPlasmodium falciparumPolyphenolsSolventsTannins

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21535822

Citation

El Babili, Fatiha, et al. "Oregano: Chemical Analysis and Evaluation of Its Antimalarial, Antioxidant, and Cytotoxic Activities." Journal of Food Science, vol. 76, no. 3, 2011, pp. C512-8.
El Babili F, Bouajila J, Souchard JP, et al. Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. J Food Sci. 2011;76(3):C512-8.
El Babili, F., Bouajila, J., Souchard, J. P., Bertrand, C., Bellvert, F., Fouraste, I., Moulis, C., & Valentin, A. (2011). Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. Journal of Food Science, 76(3), C512-8. https://doi.org/10.1111/j.1750-3841.2011.02109.x
El Babili F, et al. Oregano: Chemical Analysis and Evaluation of Its Antimalarial, Antioxidant, and Cytotoxic Activities. J Food Sci. 2011;76(3):C512-8. PubMed PMID: 21535822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oregano: chemical analysis and evaluation of its antimalarial, antioxidant, and cytotoxic activities. AU - El Babili,Fatiha, AU - Bouajila,Jalloul, AU - Souchard,Jean Pierre, AU - Bertrand,Cédric, AU - Bellvert,Florian, AU - Fouraste,Isabelle, AU - Moulis,Claude, AU - Valentin,Alexis, PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2011/8/27/medline SP - C512 EP - 8 JF - Journal of food science JO - J Food Sci VL - 76 IS - 3 N2 - GC-FID and GC-MS analysis of essential oil from oregano leaves (Origanum compactum) resulted in the identification of 46 compounds, representing more than 98% of the total composition. Carvacrol was the predominant compound (36.46%), followed by thymol (29.74%) and p-cymene (24.31%). Serial extractions with petroleum ether, ethyl acetate, ethanol, and water were performed on aerials parts of Origanum compactum. In these extracts, different chemical families were characterized: polyphenols (gallic acid equivalent 21.2 to 858.3 g/kg), tannins (catechin equivalent 12.4 to 510.3 g/kg), anthocyanins (cyanidin equivalent 0.38 to 5.63 mg/kg), and flavonoids (quercetin equivalent 14.5 to 54.7 g/kg). The samples (essential oil and extracts) were subjected to a screening for antioxidant (DPPH and ABTS assays) and antimalarial activities and against human breast cancer cells. The essential oil showed a higher antioxidant activity with an IC50=2±0.1 mg/L. Among the extracts, the aqueous extract had the highest antioxidant activity with an IC50=4.8±0.2 mg/L (DPPH assay). Concerning antimalarial activity, Origanum compactum essential oil and ethyl acetate extract showed the best results with an IC50 of 34 and 33 mg/mL, respectively. In addition, ethyl acetate extract (30 mg/L) and ethanol extract (56 mg/L) showed activity against human breast cancer cells (MCF7). The oregano essential oil was considered to be nontoxic. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/21535822/Oregano:_chemical_analysis_and_evaluation_of_its_antimalarial_antioxidant_and_cytotoxic_activities_ L2 - https://doi.org/10.1111/j.1750-3841.2011.02109.x DB - PRIME DP - Unbound Medicine ER -