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Degenerative and inflammatory markers in the cerebrospinal fluid of multiple sclerosis patients with relapsing-remitting course of disease and after clinical isolated syndrome.

Abstract

BACKGROUND

Literature includes evidence of initial predominance of inflammation and later development of neurodegeneration in the pathogenesis of multiple sclerosis (MS).

OBJECTIVE

To search for differences in inflammatory and degenerative cerebrospinal fluid (CSF) markers between relapsing-remitting MS (RRMS) and the clinical isolated syndrome (CIS).

METHODS

A total of 148 subjects were evaluated, 65 MS patients (45 RRMS and 20 CIS) and 83 controls. The evaluated parameters included albumin quotient and prealbumin, transferrin, C3 and C4 complement factors, haptoglobin, beta-2-microglobulin, orosomucoid, alpha-1-antitrypsin, apolipoprotein A-I, apolipoprotein B, cystatin C, neuron-specific enolase, tau protein, beta-amyloid, oligoclonal IgG band (OCB), and IgG quotient (QIgG).

RESULTS

No differences were found in the inflammatory and degenerative CSF markers between patients with RRMS and CIS. QIgG was higher in RRMS than that in CIS but the number of OCB was higher after CIS. Cystatin C levels were significantly lower in RRMS compared to the other groups. It can be considered an indicator of the demyelination degree. Normal values of beta-amyloid were less frequent in RRMS compared to those in controls.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, University Hospital Olomouc, Czech Republic. sladkovav@centrum.cz

    , , , , ,

    Source

    Neurological research 33:4 2011 May pg 415-20

    MeSH

    Adolescent
    Adult
    Aged
    Biological Markers
    Cerebrospinal Fluid Proteins
    Demyelinating Diseases
    Female
    Humans
    Immunoglobulins
    Inflammation Mediators
    Male
    Middle Aged
    Multiple Sclerosis, Relapsing-Remitting
    Nerve Degeneration
    Nerve Tissue Proteins
    Predictive Value of Tests
    Young Adult

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21535941