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Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the β-lactam antibiotic, ceftriaxone, in mice.
Pharmacol Biochem Behav 2011; 99(1):100-3PB

Abstract

Recently, it has been indicated that beta lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Furthermore, these antibiotics have been shown to prevent the development of tolerance and dependence to opioids. Since cannabinoid tolerance is known to be similar to opioids, our purpose was to examine the effect of ceftriaxone on the development of tolerance to WIN 55,212-2, a cannabinoid agonist. The tail flick test, a rectal thermometer, and the ring test were used for evaluating the degree of tolerance to the analgesic, hypothermic, and cataleptic effects of WIN 55,212-2, respectively. Within one week, animals became completely tolerant to analgesic, hypothermic and cataleptic effects of WIN 55,212-2 (6mg/kg). Ceftriaxone, with its higher doses (100-200mg/kg), attenuated the development of tolerance to the analgesic and hypothermic effects of WIN 55,212-2, but had no effect on its cataleptic action. Dihydrokainic acid (10mg/kg), a GLT-1 transporter inhibitor, prevented this effect of ceftriaxone. Our results suggest that repeated treatment with ceftriaxone prevents the development of tolerance to the analgesic and hypothermic effects of cannabinoids, and GLT-1 activation appears to play a key role in this preventive effect of beta-lactam antibiotics.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Trakya University, 22030-Edirne, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

21536061

Citation

Gunduz, Ozgur, et al. "Role of GLT-1 Transporter Activation in Prevention of Cannabinoid Tolerance By the Β-lactam Antibiotic, Ceftriaxone, in Mice." Pharmacology, Biochemistry, and Behavior, vol. 99, no. 1, 2011, pp. 100-3.
Gunduz O, Oltulu C, Ulugol A. Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the β-lactam antibiotic, ceftriaxone, in mice. Pharmacol Biochem Behav. 2011;99(1):100-3.
Gunduz, O., Oltulu, C., & Ulugol, A. (2011). Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the β-lactam antibiotic, ceftriaxone, in mice. Pharmacology, Biochemistry, and Behavior, 99(1), pp. 100-3. doi:10.1016/j.pbb.2011.04.012.
Gunduz O, Oltulu C, Ulugol A. Role of GLT-1 Transporter Activation in Prevention of Cannabinoid Tolerance By the Β-lactam Antibiotic, Ceftriaxone, in Mice. Pharmacol Biochem Behav. 2011;99(1):100-3. PubMed PMID: 21536061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of GLT-1 transporter activation in prevention of cannabinoid tolerance by the β-lactam antibiotic, ceftriaxone, in mice. AU - Gunduz,Ozgur, AU - Oltulu,Cagatay, AU - Ulugol,Ahmet, Y1 - 2011/04/21/ PY - 2010/12/21/received PY - 2011/03/11/revised PY - 2011/04/15/accepted PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/4/3/medline SP - 100 EP - 3 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 99 IS - 1 N2 - Recently, it has been indicated that beta lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Furthermore, these antibiotics have been shown to prevent the development of tolerance and dependence to opioids. Since cannabinoid tolerance is known to be similar to opioids, our purpose was to examine the effect of ceftriaxone on the development of tolerance to WIN 55,212-2, a cannabinoid agonist. The tail flick test, a rectal thermometer, and the ring test were used for evaluating the degree of tolerance to the analgesic, hypothermic, and cataleptic effects of WIN 55,212-2, respectively. Within one week, animals became completely tolerant to analgesic, hypothermic and cataleptic effects of WIN 55,212-2 (6mg/kg). Ceftriaxone, with its higher doses (100-200mg/kg), attenuated the development of tolerance to the analgesic and hypothermic effects of WIN 55,212-2, but had no effect on its cataleptic action. Dihydrokainic acid (10mg/kg), a GLT-1 transporter inhibitor, prevented this effect of ceftriaxone. Our results suggest that repeated treatment with ceftriaxone prevents the development of tolerance to the analgesic and hypothermic effects of cannabinoids, and GLT-1 activation appears to play a key role in this preventive effect of beta-lactam antibiotics. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/21536061/abstract/Role_of_GLT_1_transporter_ac L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(11)00122-5 DB - PRIME DP - Unbound Medicine ER -