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Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia.
Pediatrics. 2011 Jun; 127(6):e1605-9.Ped

Abstract

Mycoplasma pneumoniae is a highly specialized parasitic bacterium that is a significant cause of community-acquired pneumonia in children. Although most such respiratory infections are mild, a minor percentage of patients require hospitalization and, occasionally, intensive treatment for respiratory failure. A variety of extrapulmonary sequelae of M pneumoniae infections have been described, including Stevens-Johnson syndrome. Macrolide resistance in M pneumoniae has developed rapidly in Asia, particularly in China, over the past decade and is now appearing in the United States. Emerging resistance to macrolides creates a therapeutic conundrum, particularly for pediatricians caring for young children in whom absolute or relative contraindications exist for the use of tetracyclines or fluoroquinolones, the 2 other main classes of drugs shown to be efficacious for M pneumoniae. We describe here the case of a child with a prolonged febrile illness associated with Stevens-Johnson-like mucocutaneous involvement who was found to have a respiratory infection with macrolide-resistant M pneumoniae.

Authors+Show Affiliations

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA. patkinson@peds.uab.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

21536614

Citation

Atkinson, T Prescott, et al. "Stevens-Johnson Syndrome in a Boy With Macrolide-resistant Mycoplasma Pneumoniae Pneumonia." Pediatrics, vol. 127, no. 6, 2011, pp. e1605-9.
Atkinson TP, Boppana S, Theos A, et al. Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia. Pediatrics. 2011;127(6):e1605-9.
Atkinson, T. P., Boppana, S., Theos, A., Clements, L. S., Xiao, L., & Waites, K. (2011). Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia. Pediatrics, 127(6), e1605-9. https://doi.org/10.1542/peds.2010-2624
Atkinson TP, et al. Stevens-Johnson Syndrome in a Boy With Macrolide-resistant Mycoplasma Pneumoniae Pneumonia. Pediatrics. 2011;127(6):e1605-9. PubMed PMID: 21536614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stevens-Johnson syndrome in a boy with macrolide-resistant Mycoplasma pneumoniae pneumonia. AU - Atkinson,T Prescott, AU - Boppana,Suresh, AU - Theos,Amy, AU - Clements,L Scott, AU - Xiao,Li, AU - Waites,Ken, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2011/8/10/medline SP - e1605 EP - 9 JF - Pediatrics JO - Pediatrics VL - 127 IS - 6 N2 - Mycoplasma pneumoniae is a highly specialized parasitic bacterium that is a significant cause of community-acquired pneumonia in children. Although most such respiratory infections are mild, a minor percentage of patients require hospitalization and, occasionally, intensive treatment for respiratory failure. A variety of extrapulmonary sequelae of M pneumoniae infections have been described, including Stevens-Johnson syndrome. Macrolide resistance in M pneumoniae has developed rapidly in Asia, particularly in China, over the past decade and is now appearing in the United States. Emerging resistance to macrolides creates a therapeutic conundrum, particularly for pediatricians caring for young children in whom absolute or relative contraindications exist for the use of tetracyclines or fluoroquinolones, the 2 other main classes of drugs shown to be efficacious for M pneumoniae. We describe here the case of a child with a prolonged febrile illness associated with Stevens-Johnson-like mucocutaneous involvement who was found to have a respiratory infection with macrolide-resistant M pneumoniae. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/21536614/Stevens_Johnson_syndrome_in_a_boy_with_macrolide_resistant_Mycoplasma_pneumoniae_pneumonia_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=21536614 DB - PRIME DP - Unbound Medicine ER -