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A meta-analysis on alcohol drinking and gastric cancer risk.
Ann Oncol 2012; 23(1):28-36AO

Abstract

BACKGROUND

Whether an association between alcohol drinking and gastric cancer risk exists is an open question. In order to provide a definite quantification of the association between alcohol drinking and gastric cancer risk, we conducted a meta-analysis of available data.

PATIENTS AND METHODS

We carried out a PubMed search of articles published up to June 2010 and identified 44 case-control and 15 cohort studies, including a total of 34 557 gastric cancer cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. We carried out a dose-risk analysis using nonlinear random-effects meta-regression models.

RESULTS

Compared with nondrinkers, the pooled relative risk (RR) was 1.07 [95% confidence interval (CI) 1.01-1.13] for alcohol drinkers and 1.20 (95% CI 1.01-1.44) for heavy alcohol drinkers (≥4 drinks per day). The pooled estimates were apparently higher for gastric noncardia (RR for heavy drinkers=1.17, 95% CI 0.78-1.75) than for gastric cardia (RR=0.99, 95% CI 0.67-1.47) adenocarcinoma. The dose-risk model estimated a RR of 0.95 (95% CI 0.91-0.99) for 10 g/day and 1.14 (95% CI 1.08-1.21) for 50 g/day.

CONCLUSIONS

This meta-analysis provides definite evidence of a lack of association between moderate alcohol drinking and gastric cancer risk. There was, however, a positive association with heavy alcohol drinking.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21536659

Citation

Tramacere, I, et al. "A Meta-analysis On Alcohol Drinking and Gastric Cancer Risk." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 1, 2012, pp. 28-36.
Tramacere I, Negri E, Pelucchi C, et al. A meta-analysis on alcohol drinking and gastric cancer risk. Ann Oncol. 2012;23(1):28-36.
Tramacere, I., Negri, E., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., ... Boffetta, P. (2012). A meta-analysis on alcohol drinking and gastric cancer risk. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(1), pp. 28-36. doi:10.1093/annonc/mdr135.
Tramacere I, et al. A Meta-analysis On Alcohol Drinking and Gastric Cancer Risk. Ann Oncol. 2012;23(1):28-36. PubMed PMID: 21536659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on alcohol drinking and gastric cancer risk. AU - Tramacere,I, AU - Negri,E, AU - Pelucchi,C, AU - Bagnardi,V, AU - Rota,M, AU - Scotti,L, AU - Islami,F, AU - Corrao,G, AU - La Vecchia,C, AU - Boffetta,P, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/4/12/medline SP - 28 EP - 36 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 1 N2 - BACKGROUND: Whether an association between alcohol drinking and gastric cancer risk exists is an open question. In order to provide a definite quantification of the association between alcohol drinking and gastric cancer risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We carried out a PubMed search of articles published up to June 2010 and identified 44 case-control and 15 cohort studies, including a total of 34 557 gastric cancer cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. We carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: Compared with nondrinkers, the pooled relative risk (RR) was 1.07 [95% confidence interval (CI) 1.01-1.13] for alcohol drinkers and 1.20 (95% CI 1.01-1.44) for heavy alcohol drinkers (≥4 drinks per day). The pooled estimates were apparently higher for gastric noncardia (RR for heavy drinkers=1.17, 95% CI 0.78-1.75) than for gastric cardia (RR=0.99, 95% CI 0.67-1.47) adenocarcinoma. The dose-risk model estimated a RR of 0.95 (95% CI 0.91-0.99) for 10 g/day and 1.14 (95% CI 1.08-1.21) for 50 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of a lack of association between moderate alcohol drinking and gastric cancer risk. There was, however, a positive association with heavy alcohol drinking. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21536659/A_meta_analysis_on_alcohol_drinking_and_gastric_cancer_risk_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdr135 DB - PRIME DP - Unbound Medicine ER -