Tags

Type your tag names separated by a space and hit enter

A meta-analysis on alcohol drinking and gastric cancer risk.
Ann Oncol. 2012 Jan; 23(1):28-36.AO

Abstract

BACKGROUND

Whether an association between alcohol drinking and gastric cancer risk exists is an open question. In order to provide a definite quantification of the association between alcohol drinking and gastric cancer risk, we conducted a meta-analysis of available data.

PATIENTS AND METHODS

We carried out a PubMed search of articles published up to June 2010 and identified 44 case-control and 15 cohort studies, including a total of 34 557 gastric cancer cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. We carried out a dose-risk analysis using nonlinear random-effects meta-regression models.

RESULTS

Compared with nondrinkers, the pooled relative risk (RR) was 1.07 [95% confidence interval (CI) 1.01-1.13] for alcohol drinkers and 1.20 (95% CI 1.01-1.44) for heavy alcohol drinkers (≥4 drinks per day). The pooled estimates were apparently higher for gastric noncardia (RR for heavy drinkers=1.17, 95% CI 0.78-1.75) than for gastric cardia (RR=0.99, 95% CI 0.67-1.47) adenocarcinoma. The dose-risk model estimated a RR of 0.95 (95% CI 0.91-0.99) for 10 g/day and 1.14 (95% CI 1.08-1.21) for 50 g/day.

CONCLUSIONS

This meta-analysis provides definite evidence of a lack of association between moderate alcohol drinking and gastric cancer risk. There was, however, a positive association with heavy alcohol drinking.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21536659

Citation

Tramacere, I, et al. "A Meta-analysis On Alcohol Drinking and Gastric Cancer Risk." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 1, 2012, pp. 28-36.
Tramacere I, Negri E, Pelucchi C, et al. A meta-analysis on alcohol drinking and gastric cancer risk. Ann Oncol. 2012;23(1):28-36.
Tramacere, I., Negri, E., Pelucchi, C., Bagnardi, V., Rota, M., Scotti, L., Islami, F., Corrao, G., La Vecchia, C., & Boffetta, P. (2012). A meta-analysis on alcohol drinking and gastric cancer risk. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(1), 28-36. https://doi.org/10.1093/annonc/mdr135
Tramacere I, et al. A Meta-analysis On Alcohol Drinking and Gastric Cancer Risk. Ann Oncol. 2012;23(1):28-36. PubMed PMID: 21536659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A meta-analysis on alcohol drinking and gastric cancer risk. AU - Tramacere,I, AU - Negri,E, AU - Pelucchi,C, AU - Bagnardi,V, AU - Rota,M, AU - Scotti,L, AU - Islami,F, AU - Corrao,G, AU - La Vecchia,C, AU - Boffetta,P, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2012/4/12/medline SP - 28 EP - 36 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 1 N2 - BACKGROUND: Whether an association between alcohol drinking and gastric cancer risk exists is an open question. In order to provide a definite quantification of the association between alcohol drinking and gastric cancer risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We carried out a PubMed search of articles published up to June 2010 and identified 44 case-control and 15 cohort studies, including a total of 34 557 gastric cancer cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. We carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: Compared with nondrinkers, the pooled relative risk (RR) was 1.07 [95% confidence interval (CI) 1.01-1.13] for alcohol drinkers and 1.20 (95% CI 1.01-1.44) for heavy alcohol drinkers (≥4 drinks per day). The pooled estimates were apparently higher for gastric noncardia (RR for heavy drinkers=1.17, 95% CI 0.78-1.75) than for gastric cardia (RR=0.99, 95% CI 0.67-1.47) adenocarcinoma. The dose-risk model estimated a RR of 0.95 (95% CI 0.91-0.99) for 10 g/day and 1.14 (95% CI 1.08-1.21) for 50 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of a lack of association between moderate alcohol drinking and gastric cancer risk. There was, however, a positive association with heavy alcohol drinking. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/21536659/A_meta_analysis_on_alcohol_drinking_and_gastric_cancer_risk_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(19)39059-3 DB - PRIME DP - Unbound Medicine ER -