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Toxoplasma infection and later development of schizophrenia in mothers.
Am J Psychiatry 2011; 168(8):814-21AJ

Abstract

OBJECTIVE

Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, and a case-control study among U.S. military personnel with specimens available from both before and after diagnosis found a positive association between T. gondii immunoglobulin G (IgG) antibody level and schizophrenia. These findings have never been replicated in a prospective cohort study. The purpose of this study was to determine whether mothers infected with T. gondii have an elevated risk of schizophrenia or related disorders and whether the risk depends on IgG antibody level.

METHOD

In a register-based prospective cohort study of 45,609 women born in Denmark, the level of T. gondii-specific IgG antibodies was measured in connection with childbirth between 1992 and 1995. Women were followed up from the date of delivery until 2008.

RESULTS

A significant positive association between T. gondii IgG antibody level and schizophrenia spectrum disorders was found. Mothers with the highest IgG level had a relative risk of 1.73 (95% confidence interval [CI]=1.12-2.62) compared with mothers with the lowest IgG level. For schizophrenia, the relative risk was 1.68 (95% CI=0.77-3.46). When the mothers were classified according to IgG level, only those with the highest IgG levels had a significantly higher risk of schizophrenia spectrum disorders.

CONCLUSIONS

Women with high levels of T. gondii-specific IgG antibodies have a significantly elevated risk of developing schizophrenia spectrum disorders.

Authors+Show Affiliations

National Center for Register-Based Research, Aarhus University, Denmark. mgp@ncrr.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21536690

Citation

Pedersen, Marianne Giørtz, et al. "Toxoplasma Infection and Later Development of Schizophrenia in Mothers." The American Journal of Psychiatry, vol. 168, no. 8, 2011, pp. 814-21.
Pedersen MG, Stevens H, Pedersen CB, et al. Toxoplasma infection and later development of schizophrenia in mothers. Am J Psychiatry. 2011;168(8):814-21.
Pedersen, M. G., Stevens, H., Pedersen, C. B., Nørgaard-Pedersen, B., & Mortensen, P. B. (2011). Toxoplasma infection and later development of schizophrenia in mothers. The American Journal of Psychiatry, 168(8), pp. 814-21. doi:10.1176/appi.ajp.2011.10091351.
Pedersen MG, et al. Toxoplasma Infection and Later Development of Schizophrenia in Mothers. Am J Psychiatry. 2011;168(8):814-21. PubMed PMID: 21536690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxoplasma infection and later development of schizophrenia in mothers. AU - Pedersen,Marianne Giørtz, AU - Stevens,Hanne, AU - Pedersen,Carsten Bøcker, AU - Nørgaard-Pedersen,Bent, AU - Mortensen,Preben Bo, Y1 - 2011/05/02/ PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2011/10/1/medline SP - 814 EP - 21 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 168 IS - 8 N2 - OBJECTIVE: Several studies based on clinical samples have found an association between Toxoplasma gondii infection and schizophrenia, and a case-control study among U.S. military personnel with specimens available from both before and after diagnosis found a positive association between T. gondii immunoglobulin G (IgG) antibody level and schizophrenia. These findings have never been replicated in a prospective cohort study. The purpose of this study was to determine whether mothers infected with T. gondii have an elevated risk of schizophrenia or related disorders and whether the risk depends on IgG antibody level. METHOD: In a register-based prospective cohort study of 45,609 women born in Denmark, the level of T. gondii-specific IgG antibodies was measured in connection with childbirth between 1992 and 1995. Women were followed up from the date of delivery until 2008. RESULTS: A significant positive association between T. gondii IgG antibody level and schizophrenia spectrum disorders was found. Mothers with the highest IgG level had a relative risk of 1.73 (95% confidence interval [CI]=1.12-2.62) compared with mothers with the lowest IgG level. For schizophrenia, the relative risk was 1.68 (95% CI=0.77-3.46). When the mothers were classified according to IgG level, only those with the highest IgG levels had a significantly higher risk of schizophrenia spectrum disorders. CONCLUSIONS: Women with high levels of T. gondii-specific IgG antibodies have a significantly elevated risk of developing schizophrenia spectrum disorders. SN - 1535-7228 UR - https://www.unboundmedicine.com/medline/citation/21536690/Toxoplasma_infection_and_later_development_of_schizophrenia_in_mothers_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.2011.10091351?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -