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Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data.
Environ Toxicol Chem. 2011 Jul; 30(7):1697-703.ET

Abstract

The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca(2+) were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd-only and Pb-only toxicity data. The BLM-based toxic unit (TU) approach and the proposed BLM-based f(mix) approach were used for prediction. The predicted mixture toxic effects using the BLM-based f(mix) approach were closer to the observed mixture effects (root mean square error [RMSE] = 9.7 at 25 mM Ca(2+)) than that using the BLM-based TU approach (RMSE = 25.6 at 25 mM Ca(2+)). This can be attributed to the fact that the BLM-based TU approach only considers the competition between Ca(2+) and Cd or Pb, whereas the BLM-based f(mix) approach considers both the competition between Cd and Pb and the competition between Ca(2+) and Cd or Pb for biotic ligand sites. In addition, the parameters derived from the Cd-only and Pb-only solutions in the presence of the background Ca(2+) concentration (0.025 mM) could be used to predict the mixture toxic effects at higher Ca(2+) concentrations. The BLM-based f(mix) approach proposed in the current study suggests a new way of predicting the Cd-Pb mixture toxicity from the single metal toxicity data by adopting the f(mix) values.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Jho EH
Department of Civil and Environmental Engineering, Seoul National University, Gwanakgu, Seoul, Republic of Korea.
An J
No affiliation info available
Nam K
No affiliation info available

MeSH

Aliivibrio fischeriCadmiumCalciumDose-Response Relationship, DrugEcosystemLeadLigandsModels, BiologicalModels, ChemicalToxicity TestsWater Pollutants, Chemical

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21538486

Citation

Jho, Eun Hea, et al. "Extended Biotic Ligand Model for Prediction of Mixture Toxicity of Cd and Pb Using Single Metal Toxicity Data." Environmental Toxicology and Chemistry, vol. 30, no. 7, 2011, pp. 1697-703.
Jho EH, An J, Nam K. Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data. Environ Toxicol Chem. 2011;30(7):1697-703.
Jho, E. H., An, J., & Nam, K. (2011). Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data. Environmental Toxicology and Chemistry, 30(7), 1697-703. https://doi.org/10.1002/etc.556
Jho EH, An J, Nam K. Extended Biotic Ligand Model for Prediction of Mixture Toxicity of Cd and Pb Using Single Metal Toxicity Data. Environ Toxicol Chem. 2011;30(7):1697-703. PubMed PMID: 21538486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extended biotic ligand model for prediction of mixture toxicity of Cd and Pb using single metal toxicity data. AU - Jho,Eun Hea, AU - An,Jinsung, AU - Nam,Kyoungphile, Y1 - 2011/05/16/ PY - 2011/01/17/received PY - 2011/03/16/revised PY - 2011/04/06/accepted PY - 2011/5/4/entrez PY - 2011/5/4/pubmed PY - 2011/9/17/medline SP - 1697 EP - 703 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 30 IS - 7 N2 - The combined toxic effects of Cd and Pb in the presence of different concentrations of Ca(2+) were predicted using the biotic ligand model (BLM), with the parameters derived from the Cd-only and Pb-only toxicity data. The BLM-based toxic unit (TU) approach and the proposed BLM-based f(mix) approach were used for prediction. The predicted mixture toxic effects using the BLM-based f(mix) approach were closer to the observed mixture effects (root mean square error [RMSE] = 9.7 at 25 mM Ca(2+)) than that using the BLM-based TU approach (RMSE = 25.6 at 25 mM Ca(2+)). This can be attributed to the fact that the BLM-based TU approach only considers the competition between Ca(2+) and Cd or Pb, whereas the BLM-based f(mix) approach considers both the competition between Cd and Pb and the competition between Ca(2+) and Cd or Pb for biotic ligand sites. In addition, the parameters derived from the Cd-only and Pb-only solutions in the presence of the background Ca(2+) concentration (0.025 mM) could be used to predict the mixture toxic effects at higher Ca(2+) concentrations. The BLM-based f(mix) approach proposed in the current study suggests a new way of predicting the Cd-Pb mixture toxicity from the single metal toxicity data by adopting the f(mix) values. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/21538486/Extended_biotic_ligand_model_for_prediction_of_mixture_toxicity_of_Cd_and_Pb_using_single_metal_toxicity_data_ L2 - https://doi.org/10.1002/etc.556 DB - PRIME DP - Unbound Medicine ER -