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High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by D-galactose.
Food Chem Toxicol. 2011 Aug; 49(8):1728-36.FC

Abstract

Mice were subcutaneously injected with d-galactose (D-gal, 150 mg/kg per day) for 6 weeks and were administered high molecular weight persimmon condensed tannin (HMWPT) simultaneously. After 6 weeks of treatment, the animal behavior was observed in the open field test and water maze test, and the morphology of hippocampus and skin were checked. Meanwhile, the activities of antioxidant enzymes, the levels of non-enzymatic antioxidants, as well as malondialdehyde (MDA) were evaluated. The results indicated that HMWPT markedly inhibited the d-gal induced learning and memory impairment in both open field test and Morris water maze. Biochemical examination revealed that HMWPT significantly increased the decreased activities of superoxide dismutase (SOD), catalase (CAT), elevated the lowered total anti-oxidation capability (T-AOC), glutathione (GSH) and hydroxyproline (Hyp) contents (p<0.01 or p<0.05), and decreased the raised monoamine oxidase (MAO), total cholinesterase (TChE) activities and MDA level (p<0.01) in serum, liver or brain of aging mice induced by d-gal in a dose-dependent fashion. Furthermore, HMWPT significantly and (p<0.01) attenuated the d-gal induced number decrease, neuronal degeneration and karyopycnosis in cells in the hippocampus and decrease of thickness of skin epidermis and dermis.

Authors+Show Affiliations

College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21539885

Citation

Tian, Yan, et al. "High Molecular Weight Persimmon Tannin Ameliorates Cognition Deficits and Attenuates Oxidative Damage in Senescent Mice Induced By D-galactose." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 49, no. 8, 2011, pp. 1728-36.
Tian Y, Zou B, Yang L, et al. High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by D-galactose. Food Chem Toxicol. 2011;49(8):1728-36.
Tian, Y., Zou, B., Yang, L., Xu, S. F., Yang, J., Yao, P., & Li, C. M. (2011). High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by D-galactose. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 49(8), 1728-36. https://doi.org/10.1016/j.fct.2011.04.018
Tian Y, et al. High Molecular Weight Persimmon Tannin Ameliorates Cognition Deficits and Attenuates Oxidative Damage in Senescent Mice Induced By D-galactose. Food Chem Toxicol. 2011;49(8):1728-36. PubMed PMID: 21539885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High molecular weight persimmon tannin ameliorates cognition deficits and attenuates oxidative damage in senescent mice induced by D-galactose. AU - Tian,Yan, AU - Zou,Bo, AU - Yang,Li, AU - Xu,Shu-Fen, AU - Yang,Jie, AU - Yao,Ping, AU - Li,Chun-Mei, Y1 - 2011/04/21/ PY - 2011/01/29/received PY - 2011/04/12/revised PY - 2011/04/13/accepted PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/9/29/medline SP - 1728 EP - 36 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem Toxicol VL - 49 IS - 8 N2 - Mice were subcutaneously injected with d-galactose (D-gal, 150 mg/kg per day) for 6 weeks and were administered high molecular weight persimmon condensed tannin (HMWPT) simultaneously. After 6 weeks of treatment, the animal behavior was observed in the open field test and water maze test, and the morphology of hippocampus and skin were checked. Meanwhile, the activities of antioxidant enzymes, the levels of non-enzymatic antioxidants, as well as malondialdehyde (MDA) were evaluated. The results indicated that HMWPT markedly inhibited the d-gal induced learning and memory impairment in both open field test and Morris water maze. Biochemical examination revealed that HMWPT significantly increased the decreased activities of superoxide dismutase (SOD), catalase (CAT), elevated the lowered total anti-oxidation capability (T-AOC), glutathione (GSH) and hydroxyproline (Hyp) contents (p<0.01 or p<0.05), and decreased the raised monoamine oxidase (MAO), total cholinesterase (TChE) activities and MDA level (p<0.01) in serum, liver or brain of aging mice induced by d-gal in a dose-dependent fashion. Furthermore, HMWPT significantly and (p<0.01) attenuated the d-gal induced number decrease, neuronal degeneration and karyopycnosis in cells in the hippocampus and decrease of thickness of skin epidermis and dermis. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/21539885/High_molecular_weight_persimmon_tannin_ameliorates_cognition_deficits_and_attenuates_oxidative_damage_in_senescent_mice_induced_by_D_galactose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(11)00164-5 DB - PRIME DP - Unbound Medicine ER -