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A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.
Blood 2011; 117(25):6906-11Blood

Abstract

In the current study, we identified 2 genetic markers for susceptibility to chronic myeloid leukemia (CML) using a genome-wide analysis. A total of 2744 subjects (671 cases and 2073 controls) were included, with 202 Korean CML patients and 497 control subjects enrolled as a discovery set. Significant findings in the discovery set were validated in a second Korean set of 237 patients and 1000 control subjects and in an additional Canadian cohort of European descent, including 232 patients and 576 control subjects. Analysis revealed significant associations of 2 candidate loci, 6q25.1 and 17p11.1, with CML susceptibility, with the lowest combined P values of 2.4 × 10⁻⁶ and 1.3 × 10⁻¹², respectively. Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1. The locus 6q25.1 was validated in both Korean and European cohorts, whereas 17p11.1 was validated only in the Korean cohort. These findings suggest that genetic variants of 6q25.1 and 17p11.1 may predispose one to the development of CML.

Authors+Show Affiliations

Department of Hematology/Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21540461

Citation

Kim, Dong Hwan Dennis, et al. "A Genome-wide Association Study Identifies Novel Loci Associated With Susceptibility to Chronic Myeloid Leukemia." Blood, vol. 117, no. 25, 2011, pp. 6906-11.
Kim DH, Lee ST, Won HH, et al. A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Blood. 2011;117(25):6906-11.
Kim, D. H., Lee, S. T., Won, H. H., Kim, S., Kim, M. J., Kim, H. J., ... Lipton, J. H. (2011). A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Blood, 117(25), pp. 6906-11. doi:10.1182/blood-2011-01-329797.
Kim DH, et al. A Genome-wide Association Study Identifies Novel Loci Associated With Susceptibility to Chronic Myeloid Leukemia. Blood. 2011 Jun 23;117(25):6906-11. PubMed PMID: 21540461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. AU - Kim,Dong Hwan Dennis, AU - Lee,Seung-Tae, AU - Won,Hong-Hee, AU - Kim,Seonwoo, AU - Kim,Min-Ji, AU - Kim,Hee-Jin, AU - Kim,Sun-Hee, AU - Kim,Jong-Won, AU - Kim,Hyeoung-Joon, AU - Kim,Yeo-Kyeoung, AU - Sohn,Sang Kyun, AU - Moon,Joon Ho, AU - Jung,Chul Won, AU - Lipton,Jeffrey H, Y1 - 2011/05/03/ PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/9/6/medline SP - 6906 EP - 11 JF - Blood JO - Blood VL - 117 IS - 25 N2 - In the current study, we identified 2 genetic markers for susceptibility to chronic myeloid leukemia (CML) using a genome-wide analysis. A total of 2744 subjects (671 cases and 2073 controls) were included, with 202 Korean CML patients and 497 control subjects enrolled as a discovery set. Significant findings in the discovery set were validated in a second Korean set of 237 patients and 1000 control subjects and in an additional Canadian cohort of European descent, including 232 patients and 576 control subjects. Analysis revealed significant associations of 2 candidate loci, 6q25.1 and 17p11.1, with CML susceptibility, with the lowest combined P values of 2.4 × 10⁻⁶ and 1.3 × 10⁻¹², respectively. Candidate genes in those regions include RMND1, AKAP12, ZBTB2, and WSB1. The locus 6q25.1 was validated in both Korean and European cohorts, whereas 17p11.1 was validated only in the Korean cohort. These findings suggest that genetic variants of 6q25.1 and 17p11.1 may predispose one to the development of CML. SN - 1528-0020 UR - https://www.unboundmedicine.com/medline/citation/21540461/full_citation/A_genome_wide_association_study_identifies_novel_loci_associated_with_susceptibility_to_chronic_myeloid_leukemia_ L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=21540461 DB - PRIME DP - Unbound Medicine ER -