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Meta-analysis of prospective studies of red meat consumption and colorectal cancer.
Eur J Cancer Prev 2011; 20(4):293-307EJ

Abstract

The relationship between red meat consumption and colorectal cancer (CRC) has been the subject of scientific debate. To estimate the summary association between red meat intake and CRC and to examine sources of heterogeneity, a meta-analysis of prospective studies was conducted. Thirty-four prospective studies of red meat and CRC were identified, of which 25 represented independent nonoverlapping study populations. Summary relative risk estimates (SRREs) for high versus low intake and dose-response relationships were calculated. In the high versus low intake meta-analysis, the SRRE was 1.12 (95% CI: 1.04-1.21) with significant heterogeneity (P=0.014). Summary associations were modified by tumor site and sex. The SRREs for colon cancer and rectal cancer were 1.11 (95% CI: 1.03-1.19) and 1.19 (95% CI: 0.97-1.46), respectively. The SRREs among men and women were 1.21 (95% CI: 1.04-1.42) and 1.01 (95% CI: 0.87-1.17), respectively. The available epidemiologic data are not sufficient to support an independent and unequivocal positive association between red meat intake and CRC. This conclusion is based on summary associations that are weak in magnitude, heterogeneity across studies, inconsistent patterns of associations across the subgroup analyses, and the likely influence of confounding by other dietary and lifestyle factors.

Authors+Show Affiliations

Exponent Inc. Health Sciences, Wood Dale, Illinois 60191, USA. dalexander@exponent.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21540747

Citation

Alexander, Dominik D., et al. "Meta-analysis of Prospective Studies of Red Meat Consumption and Colorectal Cancer." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 20, no. 4, 2011, pp. 293-307.
Alexander DD, Weed DL, Cushing CA, et al. Meta-analysis of prospective studies of red meat consumption and colorectal cancer. Eur J Cancer Prev. 2011;20(4):293-307.
Alexander, D. D., Weed, D. L., Cushing, C. A., & Lowe, K. A. (2011). Meta-analysis of prospective studies of red meat consumption and colorectal cancer. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 20(4), pp. 293-307. doi:10.1097/CEJ.0b013e328345f985.
Alexander DD, et al. Meta-analysis of Prospective Studies of Red Meat Consumption and Colorectal Cancer. Eur J Cancer Prev. 2011;20(4):293-307. PubMed PMID: 21540747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analysis of prospective studies of red meat consumption and colorectal cancer. AU - Alexander,Dominik D, AU - Weed,Douglas L, AU - Cushing,Colleen A, AU - Lowe,Kimberly A, PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/9/29/medline SP - 293 EP - 307 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 20 IS - 4 N2 - The relationship between red meat consumption and colorectal cancer (CRC) has been the subject of scientific debate. To estimate the summary association between red meat intake and CRC and to examine sources of heterogeneity, a meta-analysis of prospective studies was conducted. Thirty-four prospective studies of red meat and CRC were identified, of which 25 represented independent nonoverlapping study populations. Summary relative risk estimates (SRREs) for high versus low intake and dose-response relationships were calculated. In the high versus low intake meta-analysis, the SRRE was 1.12 (95% CI: 1.04-1.21) with significant heterogeneity (P=0.014). Summary associations were modified by tumor site and sex. The SRREs for colon cancer and rectal cancer were 1.11 (95% CI: 1.03-1.19) and 1.19 (95% CI: 0.97-1.46), respectively. The SRREs among men and women were 1.21 (95% CI: 1.04-1.42) and 1.01 (95% CI: 0.87-1.17), respectively. The available epidemiologic data are not sufficient to support an independent and unequivocal positive association between red meat intake and CRC. This conclusion is based on summary associations that are weak in magnitude, heterogeneity across studies, inconsistent patterns of associations across the subgroup analyses, and the likely influence of confounding by other dietary and lifestyle factors. SN - 1473-5709 UR - http://www.unboundmedicine.com/medline/citation/21540747/Meta_analysis_of_prospective_studies_of_red_meat_consumption_and_colorectal_cancer_ L2 - http://Insights.ovid.com/pubmed?pmid=21540747 DB - PRIME DP - Unbound Medicine ER -