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Effect of dietary fiber intake on breast cancer risk according to estrogen and progesterone receptor status.
Eur J Clin Nutr 2011; 65(8):929-36EJ

Abstract

BACKGROUND/OBJECTIVES

There is few data on the association between dietary fiber intake and estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk. The present study aimed to investigate the associations between total dietary fiber and dietary fiber fractions intake and breast cancer risk by ER and PR status in a hospital-based case-control study among Chinese women.

SUBJECTS/METHODS

Four hundred and thirty-eight cases with primary breast cancer were consecutively recruited from June 2007 to August 2008 and frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). A validated food frequency questionnaire was used to assess the dietary intake through a face-to-face interview. Unconditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) after adjusting for various potential confounders.

RESULTS

A statistically significant inverse association was found between total dietary fiber and fiber fractions intake and breast cancer risk. The adjusted ORs (95% CIs) for the highest versus the lowest quartile of intake were 0.31 (0.20-0.47) for total dietary fiber, 0.73 (0.48-1.11) for soy fiber, 0.48 (0.22-0.97) for vegetable fiber and 0.54 (0.31-0.92) for fruit fiber. No association was observed for cereal fiber intake and risk. An inverse association between dietary fiber intake and breast cancer risk was observed in ER+, ER-, PR+, ER+PR+ and ER-PR+ tumors.

CONCLUSIONS

Our results suggest that consumption of total dietary fiber and fiber from vegetable and fruit was inversely associated with breast cancer risk. These inverse associations were more prominent in some subtypes of ER and PR breast cancers.

Authors+Show Affiliations

Centre of Research and Promotion of Women's Health, School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21540873

Citation

Zhang, C-X, et al. "Effect of Dietary Fiber Intake On Breast Cancer Risk According to Estrogen and Progesterone Receptor Status." European Journal of Clinical Nutrition, vol. 65, no. 8, 2011, pp. 929-36.
Zhang CX, Ho SC, Cheng SZ, et al. Effect of dietary fiber intake on breast cancer risk according to estrogen and progesterone receptor status. Eur J Clin Nutr. 2011;65(8):929-36.
Zhang, C. X., Ho, S. C., Cheng, S. Z., Chen, Y. M., Fu, J. H., & Lin, F. Y. (2011). Effect of dietary fiber intake on breast cancer risk according to estrogen and progesterone receptor status. European Journal of Clinical Nutrition, 65(8), pp. 929-36. doi:10.1038/ejcn.2011.57.
Zhang CX, et al. Effect of Dietary Fiber Intake On Breast Cancer Risk According to Estrogen and Progesterone Receptor Status. Eur J Clin Nutr. 2011;65(8):929-36. PubMed PMID: 21540873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fiber intake on breast cancer risk according to estrogen and progesterone receptor status. AU - Zhang,C-X, AU - Ho,S C, AU - Cheng,S-Z, AU - Chen,Y-M, AU - Fu,J-H, AU - Lin,F-Y, Y1 - 2011/05/04/ PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/12/16/medline SP - 929 EP - 36 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 8 N2 - BACKGROUND/OBJECTIVES: There is few data on the association between dietary fiber intake and estrogen receptor (ER)/progesterone receptor (PR)-defined breast cancer risk. The present study aimed to investigate the associations between total dietary fiber and dietary fiber fractions intake and breast cancer risk by ER and PR status in a hospital-based case-control study among Chinese women. SUBJECTS/METHODS: Four hundred and thirty-eight cases with primary breast cancer were consecutively recruited from June 2007 to August 2008 and frequency matched to 438 controls by age (5-year interval) and residence (rural/urban). A validated food frequency questionnaire was used to assess the dietary intake through a face-to-face interview. Unconditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence interval (CI) after adjusting for various potential confounders. RESULTS: A statistically significant inverse association was found between total dietary fiber and fiber fractions intake and breast cancer risk. The adjusted ORs (95% CIs) for the highest versus the lowest quartile of intake were 0.31 (0.20-0.47) for total dietary fiber, 0.73 (0.48-1.11) for soy fiber, 0.48 (0.22-0.97) for vegetable fiber and 0.54 (0.31-0.92) for fruit fiber. No association was observed for cereal fiber intake and risk. An inverse association between dietary fiber intake and breast cancer risk was observed in ER+, ER-, PR+, ER+PR+ and ER-PR+ tumors. CONCLUSIONS: Our results suggest that consumption of total dietary fiber and fiber from vegetable and fruit was inversely associated with breast cancer risk. These inverse associations were more prominent in some subtypes of ER and PR breast cancers. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21540873/Effect_of_dietary_fiber_intake_on_breast_cancer_risk_according_to_estrogen_and_progesterone_receptor_status_ L2 - http://dx.doi.org/10.1038/ejcn.2011.57 DB - PRIME DP - Unbound Medicine ER -