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A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children.
Eur J Clin Nutr 2011; 65(8):895-902EJ

Abstract

BACKGROUND/OBJECTIVES

Undernutrition and chronic suppurative otitis media (CSOM) in children are common in low resource settings, but there are few studies of their interactions. The aim is to evaluate nutritional factors associated with CSOM in Yemeni children.

SUBJECTS/METHODS

A case-control study of 75 children with CSOM and 74 healthy controls. Assessment included dietary history, anthropometry, haemoglobin (Hb) and serum analytes zinc (Zn), copper (Cu), selenium (Se), iron, calcium, phosphate (PO(4)) and total 25-hydroxy vitamin D (25(OH)D).

RESULTS

Cases had lower mean Z-scores for weight-for-age, weight-for-height, body mass index and mid-upper arm circumference (MUAC) (all P<0.05), and lower mean concentrations of serum Zn (P=0.032), Se (P<0.001) and calcium adjusted for albumin (P=0.026). Age-adjusted Hb and iron biomarkers did not differ between cases and controls. There was high prevalence of low serum Zn concentration (≥ 90%) and vitamin D deficiency in both cases (80%) and controls (96%). Duration of ear discharge was negatively correlated with total 25(OH)D (P=0.028), calcium adjusted for albumin (P<0.001), PO(4) (P=0.002), transferrin receptor/log ferritin ratio (P<0.001) and Cu (P<0.001), and positively correlated with child age and MUAC (both P<0.001).

CONCLUSIONS

Children with CSOM were more undernourished than controls with lower mean serum Zn, Se and calcium concentrations. Vitamin D-deficient and iron-replete children had longer duration of infection, although this association was lost with age adjustment. Trials evaluating specific micronutrients are required in order to investigate specific nutrient-infection interactions in CSOM.

Authors+Show Affiliations

WHO Collaborating Centre for Prevention of Hearing Impairment, Child and Reproductive Health Group, Liverpool School of Tropical Medicine, Liverpool, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21540875

Citation

Elemraid, M A., et al. "A Case-control Study of Nutritional Factors Associated With Chronic Suppurative Otitis Media in Yemeni Children." European Journal of Clinical Nutrition, vol. 65, no. 8, 2011, pp. 895-902.
Elemraid MA, Mackenzie IJ, Fraser WD, et al. A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children. Eur J Clin Nutr. 2011;65(8):895-902.
Elemraid, M. A., Mackenzie, I. J., Fraser, W. D., Harper, G., Faragher, B., Atef, Z., ... Brabin, B. J. (2011). A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children. European Journal of Clinical Nutrition, 65(8), pp. 895-902. doi:10.1038/ejcn.2011.58.
Elemraid MA, et al. A Case-control Study of Nutritional Factors Associated With Chronic Suppurative Otitis Media in Yemeni Children. Eur J Clin Nutr. 2011;65(8):895-902. PubMed PMID: 21540875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children. AU - Elemraid,M A, AU - Mackenzie,I J, AU - Fraser,W D, AU - Harper,G, AU - Faragher,B, AU - Atef,Z, AU - Al-Aghbari,N, AU - Brabin,B J, Y1 - 2011/05/04/ PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/12/16/medline SP - 895 EP - 902 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 65 IS - 8 N2 - BACKGROUND/OBJECTIVES: Undernutrition and chronic suppurative otitis media (CSOM) in children are common in low resource settings, but there are few studies of their interactions. The aim is to evaluate nutritional factors associated with CSOM in Yemeni children. SUBJECTS/METHODS: A case-control study of 75 children with CSOM and 74 healthy controls. Assessment included dietary history, anthropometry, haemoglobin (Hb) and serum analytes zinc (Zn), copper (Cu), selenium (Se), iron, calcium, phosphate (PO(4)) and total 25-hydroxy vitamin D (25(OH)D). RESULTS: Cases had lower mean Z-scores for weight-for-age, weight-for-height, body mass index and mid-upper arm circumference (MUAC) (all P<0.05), and lower mean concentrations of serum Zn (P=0.032), Se (P<0.001) and calcium adjusted for albumin (P=0.026). Age-adjusted Hb and iron biomarkers did not differ between cases and controls. There was high prevalence of low serum Zn concentration (≥ 90%) and vitamin D deficiency in both cases (80%) and controls (96%). Duration of ear discharge was negatively correlated with total 25(OH)D (P=0.028), calcium adjusted for albumin (P<0.001), PO(4) (P=0.002), transferrin receptor/log ferritin ratio (P<0.001) and Cu (P<0.001), and positively correlated with child age and MUAC (both P<0.001). CONCLUSIONS: Children with CSOM were more undernourished than controls with lower mean serum Zn, Se and calcium concentrations. Vitamin D-deficient and iron-replete children had longer duration of infection, although this association was lost with age adjustment. Trials evaluating specific micronutrients are required in order to investigate specific nutrient-infection interactions in CSOM. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/21540875/A_case_control_study_of_nutritional_factors_associated_with_chronic_suppurative_otitis_media_in_Yemeni_children_ L2 - http://dx.doi.org/10.1038/ejcn.2011.58 DB - PRIME DP - Unbound Medicine ER -