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Apolipoprotein E gene and age-related macular degeneration in a Chinese population.
Mol Vis. 2011 Apr 20; 17:997-1002.MV

Abstract

PURPOSE

To examine the association between apolipoprotein E (APOE) polymorphisms and age-related macular degeneration (AMD) in a Chinese population.

METHODS

The study consisted of 712 subjects, including 201 controls, 363 cases with early AMD, and 148 cases with exudative AMD. Genomic DNA was extracted from venous blood leukocytes. Common allelic variants of APOE (ε2, ε3, and ε4) were analyzed by PCR and direct sequencing.

RESULTS

APOE ε3ε3 was the most frequent genotype, with a frequency of 72.6% in controls, 72.5% in early AMD, and 70.3% in exudative AMD. Frequency of the ε2 allele was 6.7% in controls, 7.4% in early AMD, and 8.8% in exudative AMD. Frequency of the ε4 allele was 8.7% in controls, 7.7% in early AMD, and 7.8% in exudative AMD. No statistically significant difference in APOE genotype and allele frequency distribution was observed among controls, cases with early AMD, and cases with exudative AMD. For ε2 allele carriers, the odds ratio was 1.12 (95% confidence interval [CI], 0.65-1.93) for early AMD and 1.06 (95% CI, 0.53-2.10) for exudative AMD. For ε4 allele carriers, the odds ratio was 1.04 (95% CI, 0.61-1.75) for early AMD and 0.83 (95% CI, 0.42-1.62) for exudative AMD.

CONCLUSIONS

Our data provide no evidence to support an association of APOE polymorphisms with early or exudative AMD, suggesting that APOE is less likely to be a major AMD susceptibility gene in the Chinese population.

Authors+Show Affiliations

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21541275

Citation

Sun, Erdan, et al. "Apolipoprotein E Gene and Age-related Macular Degeneration in a Chinese Population." Molecular Vision, vol. 17, 2011, pp. 997-1002.
Sun E, Lim A, Liu X, et al. Apolipoprotein E gene and age-related macular degeneration in a Chinese population. Mol Vis. 2011;17:997-1002.
Sun, E., Lim, A., Liu, X., Snellingen, T., Wang, N., & Liu, N. (2011). Apolipoprotein E gene and age-related macular degeneration in a Chinese population. Molecular Vision, 17, 997-1002.
Sun E, et al. Apolipoprotein E Gene and Age-related Macular Degeneration in a Chinese Population. Mol Vis. 2011 Apr 20;17:997-1002. PubMed PMID: 21541275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene and age-related macular degeneration in a Chinese population. AU - Sun,Erdan, AU - Lim,Apiradee, AU - Liu,Xipu, AU - Snellingen,Torkel, AU - Wang,Ningli, AU - Liu,Ningpu, Y1 - 2011/04/20/ PY - 2010/10/08/received PY - 2011/04/17/accepted PY - 2011/5/5/entrez PY - 2011/5/5/pubmed PY - 2011/9/9/medline SP - 997 EP - 1002 JF - Molecular vision JO - Mol Vis VL - 17 N2 - PURPOSE: To examine the association between apolipoprotein E (APOE) polymorphisms and age-related macular degeneration (AMD) in a Chinese population. METHODS: The study consisted of 712 subjects, including 201 controls, 363 cases with early AMD, and 148 cases with exudative AMD. Genomic DNA was extracted from venous blood leukocytes. Common allelic variants of APOE (ε2, ε3, and ε4) were analyzed by PCR and direct sequencing. RESULTS: APOE ε3ε3 was the most frequent genotype, with a frequency of 72.6% in controls, 72.5% in early AMD, and 70.3% in exudative AMD. Frequency of the ε2 allele was 6.7% in controls, 7.4% in early AMD, and 8.8% in exudative AMD. Frequency of the ε4 allele was 8.7% in controls, 7.7% in early AMD, and 7.8% in exudative AMD. No statistically significant difference in APOE genotype and allele frequency distribution was observed among controls, cases with early AMD, and cases with exudative AMD. For ε2 allele carriers, the odds ratio was 1.12 (95% confidence interval [CI], 0.65-1.93) for early AMD and 1.06 (95% CI, 0.53-2.10) for exudative AMD. For ε4 allele carriers, the odds ratio was 1.04 (95% CI, 0.61-1.75) for early AMD and 0.83 (95% CI, 0.42-1.62) for exudative AMD. CONCLUSIONS: Our data provide no evidence to support an association of APOE polymorphisms with early or exudative AMD, suggesting that APOE is less likely to be a major AMD susceptibility gene in the Chinese population. SN - 1090-0535 UR - https://www.unboundmedicine.com/medline/citation/21541275/Apolipoprotein_E_gene_and_age_related_macular_degeneration_in_a_Chinese_population_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541275/ DB - PRIME DP - Unbound Medicine ER -