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Epigenetic regulation of satellite cell activation during muscle regeneration.
Stem Cell Res Ther. 2011 Apr 19; 2(2):18.SC

Abstract

Satellite cells are a population of adult muscle stem cells that play a key role in mediating muscle regeneration. Activation of these quiescent stem cells in response to muscle injury involves modulating expression of multiple developmentally regulated genes, including mediators of the muscle-specific transcription program: Pax7, Myf5, MyoD and myogenin. Here we present evidence suggesting an essential role for the antagonistic Polycomb group and Trithorax group proteins in the epigenetic marking of muscle-specific genes to ensure proper temporal and spatial expression during muscle regeneration. The importance of Polycomb group and Trithorax group proteins in establishing chromatin structure at muscle-specific genes suggests that therapeutic modulation of their activity in satellite cells could represent a viable approach for repairing damaged muscle in muscular dystrophy.

Authors+Show Affiliations

Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, 501 Smyth Road, Mailbox 511, Ottawa, Ontario, Canada K1H 8L6. jdilworth@ohri.caNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21542881

Citation

Dilworth, F Jeffrey, and Alexandre Blais. "Epigenetic Regulation of Satellite Cell Activation During Muscle Regeneration." Stem Cell Research & Therapy, vol. 2, no. 2, 2011, p. 18.
Dilworth FJ, Blais A. Epigenetic regulation of satellite cell activation during muscle regeneration. Stem Cell Res Ther. 2011;2(2):18.
Dilworth, F. J., & Blais, A. (2011). Epigenetic regulation of satellite cell activation during muscle regeneration. Stem Cell Research & Therapy, 2(2), 18. https://doi.org/10.1186/scrt59
Dilworth FJ, Blais A. Epigenetic Regulation of Satellite Cell Activation During Muscle Regeneration. Stem Cell Res Ther. 2011 Apr 19;2(2):18. PubMed PMID: 21542881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epigenetic regulation of satellite cell activation during muscle regeneration. AU - Dilworth,F Jeffrey, AU - Blais,Alexandre, Y1 - 2011/04/19/ PY - 2011/5/6/entrez PY - 2011/5/6/pubmed PY - 2011/5/6/medline SP - 18 EP - 18 JF - Stem cell research & therapy JO - Stem Cell Res Ther VL - 2 IS - 2 N2 - Satellite cells are a population of adult muscle stem cells that play a key role in mediating muscle regeneration. Activation of these quiescent stem cells in response to muscle injury involves modulating expression of multiple developmentally regulated genes, including mediators of the muscle-specific transcription program: Pax7, Myf5, MyoD and myogenin. Here we present evidence suggesting an essential role for the antagonistic Polycomb group and Trithorax group proteins in the epigenetic marking of muscle-specific genes to ensure proper temporal and spatial expression during muscle regeneration. The importance of Polycomb group and Trithorax group proteins in establishing chromatin structure at muscle-specific genes suggests that therapeutic modulation of their activity in satellite cells could represent a viable approach for repairing damaged muscle in muscular dystrophy. SN - 1757-6512 UR - https://www.unboundmedicine.com/medline/citation/21542881/Epigenetic_regulation_of_satellite_cell_activation_during_muscle_regeneration_ L2 - https://stemcellres.biomedcentral.com/articles/10.1186/scrt59 DB - PRIME DP - Unbound Medicine ER -